Beneficial effect of growth hormone on atherogenic risk in children with growth hormone deficiency

Kohno, Hitoshi; Ueyama, N.; Yanai, Shinji; Ukaji, Koutaro; Honda, Sunao

doi:10.1016/s0022-3476(95)70220-2

Cited by 37 publications

(39 citation statements)

References 12 publications

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“…The reported effects of GHD on serum lipids in children with GHD are inconsistent between studies. Some studies showed no changes in TC and HDL during 6 -12 months of GHRx (12), whereas others found a decrease in TC (13) or an increase in HDL (11). In the present study, the atherogenic index decreased, in agreement with a study of Kohno et al (11) in prepubertal boys during 9 months of GH therapy.…”

Section: Discussionsupporting

confidence: 91%

“…Some studies showed no changes in TC and HDL during 6 -12 months of GHRx (12), whereas others found a decrease in TC (13) or an increase in HDL (11). In the present study, the atherogenic index decreased, in agreement with a study of Kohno et al (11) in prepubertal boys during 9 months of GH therapy. In a study evaluating the efficacy of lipid profiles, the atherogenic index was the most efficient predictor of coronary heart disease in adults (50).…”

Section: Discussionsupporting

confidence: 91%

“…Reduction in triglycerides (TG) and low-density lipoprotein cholesterol (LDL) and increase of high-density lipoprotein cholesterol (HDL) have been observed in adults with GHD during therapy (8 -10). Reports of lipid metabolism during GHRx in children with GHD are contradictory (11)(12)(13).…”

Section: G H Is Essential For Normal Growth During Childhoodmentioning

confidence: 99%

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Changes in Bone Mineral Density, Body Composition, and Lipid Metabolism during Growth Hormone (GH) Treatment in Children with GH Deficiency

Boot¹

1997

Journal of Clinical Endocrinology & Metabolism

115

142

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Adults with childhood onset GH deficiency (GHD) have reduced bone mass, increased fat mass, and disorders of lipid metabolism. The aim of the present study was to evaluate bone mineral density (BMD), bone metabolism, body composition, and lipid metabolism in GHD children before and during 2-3 yr of GH treatment (GHRx). Forty children with GHD, mean age 7.9 yr, participated in the study of bone metabolism and body composition; and an additional group of 17 GHD children, in the study of lipid metabolism. Lumbar spine BMD, total body BMD, and body composition were measured with dual-energy x-ray absorptiometry. Volumetric BMD (bone mineral apparent density, BMAD) was calculated to correct for bone size. BMD, BMAD, lean tissue mass, bone mineral content, fat mass, and percentage body fat were expressed as SD scores (SDS), in comparison with normative data of the same population. Lumbar spine BMD and BMAD and total body BMD were all decreased at baseline. All BMD variables increased significantly during GHRx, lumbar spine BMD SDS, already after 6 months of treatment. Lean tissue mass SDS increased continuously. Bone mineral content SDS started to increase after 6 months GHRx. Fat mass SDS decreased during the first 6 months of GHRx and remained stable thereafter. Biochemical parameters of bone formation and bone resorption did not differ from normal at baseline and increased during the first 6 months of GHRx. Serum 1,25 dihydroxyvitamin D increased continuously during GHRx, whereas PTH and serum calcium remained stable. Lipid profile was normal at baseline. Atherogenic index had decreased and apolipoprotein A1 (Apo-A1) had increased after 3 yr of treatment.In conclusion, children with GHD have decreased bone mass. BMD, together with height and lean tissue mass, increased during GHRx. GHRx had a beneficial effect on lipid metabolism. (J Clin Endocrinol

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Changes in Bone Mineral Density, Body Composition, and Lipid Metabolism during Growth Hormone (GH) Treatment in Children with GH Deficiency

Boot¹

1997

Journal of Clinical Endocrinology & Metabolism

115

142

View full text Add to dashboard Cite

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“…In a similar survey 12 patients treated for 9 months, HDL cholesterol increased significantly, total cholesterol didn't change and atherogenic index decreased until 5 months [4,16]. In a survey in which 17 children were followed for 3 years atherogenic index decreased and apolipoproteinA1 which is the main apolipoprotein of HDL cholesterol decreased also.…”

Section: Methodsmentioning

confidence: 95%

“…In a study done by Keizer Schrama et al, it was shown that Growth Hormone decreased the levels of total cholesterol, Low density Lipoprotein and Apolipoprotein-B in 38 Growth Hormone deficient patients [3]. In a survey done by Kohno et al, it was also shown that Growth Hormone treatment for 9 months didn't differ total cholesterol level, however it increased High Density Lipoprotein cholesterol level [4].…”

Section: Introductionmentioning

confidence: 99%

The effects of growth hormone treatment on lipid parameters

Ünlü¹

2016

Clin Case Rep Rev

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A Cross-Sectional Cohort Study of Cerebrovascular Disease and Late Effects After Radiation Therapy for Craniopharyngioma

Howard

Nichol

et al. 2016

Pediatr Blood Cancer

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Beneficial effect of growth hormone on atherogenic risk in children with growth hormone deficiency

Cited by 37 publications

References 12 publications

Changes in Bone Mineral Density, Body Composition, and Lipid Metabolism during Growth Hormone (GH) Treatment in Children with GH Deficiency

Changes in Bone Mineral Density, Body Composition, and Lipid Metabolism during Growth Hormone (GH) Treatment in Children with GH Deficiency

The effects of growth hormone treatment on lipid parameters

A Cross-Sectional Cohort Study of Cerebrovascular Disease and Late Effects After Radiation Therapy for Craniopharyngioma

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