Beneficial effect of EPA (20:5 n-3 PUFA) on preventing venous thromboembolism: A rat tail thrombosis model experiment

Kuma, Hiroyuki; Nagashima, Risa; Hatae, Hinako; Tsuda, Teruhisa

doi:10.1016/j.thromres.2012.09.014

Cited by 12 publications

(9 citation statements)

References 9 publications

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“…Thus, we would like to propose that a low EPA/AA ratio might be one of the underlying conditions to raise platelet activities and that the anti-platelet effect of EPA could have preventive actions against venous thrombosis and PTE. A recent report, which showed that administration of EPA prevented venous thromboembolism in a rat model (14), further supports our proposal.…”

Section: Resultssupporting

confidence: 90%

Serum Eicosapentaenoic Acid/Arachidonic Acid Ratio Is Low in Patients with Pulmonary Thromboembolism

Oshima

Niki

Hiramoto

et al. 2013

J Nutr Sci Vitaminol

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Recently n-3 polyunsaturated fatty acids (PUFAs) have been reported to play protective roles against cardiovascular diseases. Pulmonary thromboembolism (PTE) is one of the critical diseases in the circulatory system. However the relationship between n-3 PUFAs and PTE has not been reported. A total of 144 outpatients of the division of cardiology, including 12 of PTE cases, were enrolled in the present study and serum levels of eicosapentaenoic acid (EPA) and arachidonic acid (AA) were analyzed. We found that the EPA/AA ratio of the patients with PTE (the PTE group) was significantly lower than that of the patients without PTE (the non-PTE group) (p=0.007 for log EPA/log AA ratio). Next, the PTE group was divided into two groups by the presence or absence of malignant carcinoma. The PTE without carcinoma group showed significantly lower EPA/AA ratio than that of the non-PTE group (p=0.002 for log EPA/log AA ratio). However, the PTE with carcinoma group did not show the statistical difference in EPA/AA ratio compared with the non-PTE group (p=0.39). These data indicate that PTE may be associated with a low EPA/AA ratio, although the presence of malignant carcinoma should be taken into account.

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Section: Resultssupporting

confidence: 90%

Serum Eicosapentaenoic Acid/Arachidonic Acid Ratio Is Low in Patients with Pulmonary Thromboembolism

Oshima

Niki

Hiramoto

et al. 2013

J Nutr Sci Vitaminol

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“…Recently, we have reported that ALA did not prevent acute venous thrombosis in mice in a model of vena cava stenosis or in a model of photochemical‐induced venous endothelial injury . Consistent with these results, long‐chain n‐3 FAs did not prevent venous thrombosis in a model of stasis and hypercoagulability , whereas others have demonstrated beneficial effects of the long‐chain n‐3 FA EPA . These inconsistent results in rodents may be difficult to translate to the human situation, especially to elderly patients with multiple risk factors, a setting which cannot be modeled in animals.…”

Section: Discussionmentioning

confidence: 74%

“…We and others have found plausible mechanisms in experimental studies by which n‐3 FAs may prevent venous thrombosis, including anti‐inflammatory, antiplatelet and anticoagulant properties . Recently, we have reported that ALA did not prevent acute venous thrombosis in mice in a model of vena cava stenosis or in a model of photochemical‐induced venous endothelial injury .…”

Section: Discussionmentioning

confidence: 88%

“…Thus, determining whole-blood n-3 FA content by gas chromatography, an analytical procedure with low variability [38], reflects patients' n-3 FA status more reliably and appropriately. We and others have found plausible mechanisms in experimental studies by which n-3 FAs may prevent venous thrombosis, including anti-inflammatory, antiplatelet and anticoagulant properties [8,9,39]. Recently, we have reported that ALA did not prevent acute venous thrombosis in mice in a model of vena cava stenosis or in a model of photochemical-induced venous endothelial injury [40].…”

Section: Discussionmentioning

confidence: 99%

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Omega‐3 fatty acids predict recurrent venous thromboembolism or total mortality in elderly patients with acute venous thromboembolism

Reiner

Stivala

Limacher

et al. 2017

Journal of Thrombosis and Haemostasis

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To cite this article: Reiner MF, Stivala S, Limacher A, Bonetti NR, M ean M, Egloff M, Rodondi N, Aujesky D, von Schacky C, L€ uscher TF, Camici GG, Beer JH. Omega-3 fatty acids predict recurrent venous thromboembolism or total mortality in elderly patients with acute venous thromboembolism. J Thromb Haemost 2017; 15: 47-56. Essentials• The role of omega-3 fatty acids (n-3 FAs) in recurrent venous thromboembolism (VTE) is unknown.• Association of n-3 FAs with recurrent VTE or total mortality was investigated in 826 patients.• Whole blood n-3 FAs were inversely correlated with recurrent VTE or total mortality.• Major and non-major bleeding was not increased in patients with higher levels of n-3 FAs.Summary. Background: The role of omega-3 fatty acids (n-3 FAs) in recurrent venous thromboembolism (VTE) remains unknown. Objectives: To investigate the association of n-3 FAs with recurrent VTE or total mortality at 6 months and 3 years. Methods: N-3 FAs were assessed in 826 patients aged ≥ 65 years, categorized into low, medium and high based on the 25th and 75th percentile. Mean follow-up was 29 months. Results: At 6 months, subjects with medium (adjusted hazard ratio [HR], 0.37; 95% confidence interval [CI], 0.22-0.62) and high n-3 FA levels (adjusted HR, 0.36; 95% CI, 0.20-0.67) were less likely to develop recurrent VTE or total mortality, compared with those with low n-3 FAs. At 3 years, medium levels (adjusted HR, 0.67; 95% CI, 0.47-0.96) were associated with lower risk of recurrent VTE or total mortality. As compared with low n-3 FAs, the adjusted subhazard ratio [SHR] of recurrent VTE was 0.39 (95% CI, 0.15-0.99) in patients with medium and 0.17 (95% CI, 0.03-0.82) in patients with high n-3 FAs. The cumulative incidence of recurrent VTE was lower in the medium and high n-3 FA groups as compared with the low n-3 FA groups, but seems to have worn off after 3 years. The incidence of major and non-major bleeding was not greater in the high n-3 FA group. Conclusion: Higher levels of n-3 FAs were associated with a lower risk of recurrent VTE or total mortality in elderly patients with VTE, but not with greater bleeding risk.

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“…EPA and DHA are important omega-3 fatty acids that are indispensable to the human health [10] but the human body cannot produce them directly [11]. They have various physiological effects such as lowering blood lipids, blood pressure, and cholesterol, preventing arteriosclerosis [12], reducing thrombosis [13], and preventing cardiovascular [14] and cerebrovascular diseases [15]. In addition to the above effects, DHA can protect the retina, improve vision [16], promote infants' intellectual development, and improve memory [17].…”

Section: Introductionmentioning

confidence: 99%

Cod-Liver Oil Improves Metabolic Indices and hs-CRP Levels in Gestational Diabetes Mellitus Patients: A Double-Blind Randomized Controlled Trial

Yang

Lin

et al. 2019

Journal of Diabetes Research

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Objective. To investigate the effects of cod-liver oil on metabolic status and high-sensitivity C-reactive protein (hs-CRP) in patients with gestational diabetes mellitus (GDM). Methods. This study was a randomized, double-blinded, placebo-controlled trial with the allocation ratio of 1 : 1. The contents of EPA and DHA in cod-liver oil were measured using a gas chromatograph. A total of 550 GDM patients were randomly divided into the intervention group (cod-liver oil) and the control group (placebo, mineral oil), and both groups were given regular dietary care. Glycosylated hemoglobin A1c (HbA1c), fasting plasma glucose (FPG), 2-hour plasma glucose (2hPG), lipid profiles, homeostatic model assessment insulin resistance (HOMA-IR), and hs-CRP were measured. Primary outcomes were different in HbA1c, FPG, 2hPG, and HOMA-IR between the two groups after 4-week randomization. Secondary outcomes were the blood glucose levels and perinatal complications (pregnancy-induced hypertension, polyhydramnios, premature delivery, postpartum hemorrhage, postpartum infection, premature rupture of membranes, and cesarean section) between the two groups before and after 12-16 weeks of cod-liver oil intervention from middle pregnancy to late pregnancy. Results. EPA and DHA were the main components of cod-liver oil with 76 mg/mL and 150 mg/mL, respectively. There was no significant difference for primary outcomes in the levels of HbA1c, FPG, 2hPG, HOMA-IR, and lipid profiles between the two groups (P>0.05). For the secondary outcomes, the levels of HbA1c, FPG, 2hPG, triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol ratio (LDL-C), HOMA-IR, and hs-CRP in the intervention group were significantly lower than those in the control group (P<0.05). The incidence of perinatal complications in the intervention group was lower than that in the control group too (P<0.05). Conclusions. Cod-liver oil consumption effectively reduced the levels of blood glucose, lipid levels, hs-CRP, and HOMA-IR and the incidence of perinatal complications.

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Beneficial effect of EPA (20:5 n-3 PUFA) on preventing venous thromboembolism: A rat tail thrombosis model experiment

Cited by 12 publications

References 9 publications

Serum Eicosapentaenoic Acid/Arachidonic Acid Ratio Is Low in Patients with Pulmonary Thromboembolism

Serum Eicosapentaenoic Acid/Arachidonic Acid Ratio Is Low in Patients with Pulmonary Thromboembolism

Omega‐3 fatty acids predict recurrent venous thromboembolism or total mortality in elderly patients with acute venous thromboembolism

Cod-Liver Oil Improves Metabolic Indices and hs-CRP Levels in Gestational Diabetes Mellitus Patients: A Double-Blind Randomized Controlled Trial

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