Beneficial Effect of Endovascular Treatment on Villalta Score in Japanese Patients With Chronic Iliofemoral Venous Thrombosis and Post-Thrombotic Syndrome

Ueda, Jin; Tsuji, Akiko; Ogo, Takeshi; Asano, Ryotaro; Konagai, Nao; Fukui, Shigefumi; Morita, Yoshiaki; Fukuda, Tsuyoshi; Yasuda, Satoshi

doi:10.1253/circj.cj-17-1210

Cited by 4 publications

(4 citation statements)

References 38 publications

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“…Complications such as PE and PTS caused by DVT are life-threatening [4,5,9]. Thrombus revascularization is an important event in the resolution of DVT [12,13].…”

Section: Discussionmentioning

confidence: 99%

“…The main consequences of DVT are death, recurrence, PTS, and major bleeding caused by anticoagulation [5,8]. Consequently, the quality of life of patients with DVT is severely affected, especially when PTS is present [5,9]. Approximately 900,000 new cases of DVT are estimated each year in the United States alone, with a mortality rate close to 300,000 cases per year [10,11].…”

mentioning

confidence: 99%

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LncRNA GUSBP5-AS promotes EPC migration and angiogenesis and deep vein thrombosis resolution by regulating FGF2 and MMP2/9 through the miR-223-3p/FOXO1/Akt pathway

Sun

Lei

Jiang

et al. 2020

Aging

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INTRODUCTIONDeep vein thrombosis (DVT) is a blood clot that forms within a deep vein, especially in leg veins such as the femoral vein. The prevalence of DVT is slightly higher in men than in women [1] and increases with age [2]. Approximately 20%-50% of patients after a first DVT event suffer from post-thrombotic syndrome (PTS), which involves intractable edema, pain, a sensation of heaviness, pigmentation, and even venous ulcers in severe cases [1,3]. In addition, DVT can be potentially life-threatening when a blood clot breaks off and develops into pulmonary embolism (PE), leading to sudden cardiovascular collapse and death [4,5]. DVT and PE form a single disease process named venous thromboembolism (VTE), which is the third most common vascular disease in the United States [6,7]. The main consequences of DVT are death, recurrence, PTS, and major bleeding caused by anticoagulation [5,8]. Consequently, the quality of life of patients with DVT is severely affected, especially when PTS is present [5,9]. Approximately 900,000 new cases of DVT are estimated each year in the United States alone, with a mortality rate close to 300,000 cases per year [10,11]. Therefore, it is important and necessary to study the molecular mechanism of DVT and to explore alternative therapies.

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“…Complications such as PE and PTS caused by DVT are life-threatening [4,5,9]. Thrombus revascularization is an important event in the resolution of DVT [12,13].…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

LncRNA GUSBP5-AS promotes EPC migration and angiogenesis and deep vein thrombosis resolution by regulating FGF2 and MMP2/9 through the miR-223-3p/FOXO1/Akt pathway

Sun

Lei

Jiang

et al. 2020

Aging

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show abstract

“…Studies have shown that recurrence, PTS, hemorrhage caused by anticoagulation, and death are the main adverse consequences of DVT [ 32 , 41 ]. In patients with DVT, especially those with PTS, their quality of life is severely affected [ 32 , 42 ]. In summary, these are difficult problems in the treatment of DVT in clinical work.…”

Section: Characteristics Of Venous Thrombosismentioning

confidence: 99%

Non-coding RNAs regulating endothelial progenitor cells for venous thrombosis: promising therapy and innovation

Sun,

Liu,

Ran

et al. 2024

Stem Cell Res Ther

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Venous thromboembolism, which includes deep venous thrombosis (DVT) and pulmonary embolism, is the third most common vascular disease in the world and seriously threatens the lives of patients. Currently, the effect of conventional treatments on DVT is limited. Endothelial progenitor cells (EPCs) play an important role in the resolution and recanalization of DVT, but an unfavorable microenvironment reduces EPC function. Non-coding RNAs, especially long non-coding RNAs and microRNAs, play a crucial role in improving the biological function of EPCs. Non-coding RNAs have become clinical biomarkers of diseases and are expected to serve as new targets for disease intervention. A theoretical and experimental basis for the development of new methods for preventing and treating DVT in the clinic will be provided by studies on the role and molecular mechanism of non-coding RNAs regulating EPC function in the occurrence and development of DVT. To summarize, the characteristics of venous thrombosis, the regulatory role of EPCs in venous thrombosis, and the effect of non-coding RNAs regulating EPCs on venous thrombosis are reviewed. This summary serves as a useful reference and theoretical basis for research into the diagnosis, prevention, treatment, and prognosis of venous thrombosis.

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“…In addition, DVT can be fatal when the thrombus dislodges and progresses to Pulmonary Embolism (PE), leading to sudden heart failure and death (Boon et al 2018 ; Tapson and Humbert 2006 ). Consequently, the quality of life and economic status of DVT patients are severely affected, especially in the presence of PTS (Ueda et al 2018 ). Addressing the acute management of DVT and reducing the risk of PTS have emerged as significant challenges for vascular surgeons.…”

Section: Introductionmentioning

confidence: 99%

HOXD9 regulated mitophagy to promote endothelial progenitor cells angiogenesis and deep vein thrombosis recanalization and resolution

Xiujin,

Lili,

Jing

et al. 2024

Mol Med

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Background Deep vein thrombosis (DVT) is a common vascular surgical disease caused by the coagulation of blood in the deep veins, and predominantly occur in the lower limbs. Endothelial progenitor cells (EPCs) are multi-functional stem cells, which are precursors of vascular endothelial cells. EPCs have gradually evolved into a promising treatment strategy for promoting deep vein thrombus dissolution and recanalization through the stimulation of various physical and chemical factors. Methods In this study, we utilized a mouse DVT model and performed several experiments including qRT-PCR, Western blot, tube formation, wound healing, Transwell assay, immunofluorescence, flow cytometry analysis, and immunoprecipitation to investigate the role of HOXD9 in the function of EPCs cells. The therapeutic effect of EPCs overexpressing HOXD9 on the DVT model and its mechanism were also explored. Results Overexpression of HOXD9 significantly enhanced the angiogenesis and migration abilities of EPCs, while inhibiting cell apoptosis. Additionally, results indicated that HOXD9 specifically targeted the HRD1 promoter region and regulated the downstream PINK1-mediated mitophagy. Interestingly, intravenous injection of EPCs overexpressing HOXD9 into mice promoted thrombus dissolution and recanalization, significantly decreasing venous thrombosis. Conclusions The findings of this study reveal that HOXD9 plays a pivotal role in stimulating vascular formation in endothelial progenitor cells, indicating its potential as a therapeutic target for DVT management. Graphical Abstract

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Beneficial Effect of Endovascular Treatment on Villalta Score in Japanese Patients With Chronic Iliofemoral Venous Thrombosis and Post-Thrombotic Syndrome

Cited by 4 publications

References 38 publications

LncRNA GUSBP5-AS promotes EPC migration and angiogenesis and deep vein thrombosis resolution by regulating FGF2 and MMP2/9 through the miR-223-3p/FOXO1/Akt pathway

LncRNA GUSBP5-AS promotes EPC migration and angiogenesis and deep vein thrombosis resolution by regulating FGF2 and MMP2/9 through the miR-223-3p/FOXO1/Akt pathway

Non-coding RNAs regulating endothelial progenitor cells for venous thrombosis: promising therapy and innovation

HOXD9 regulated mitophagy to promote endothelial progenitor cells angiogenesis and deep vein thrombosis recanalization and resolution

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