Beneficial effect of butyrate,<i>Lactobacillus casei</i>and L-carnitine combination in preference to each in experimental colitis

Moeinian, Mahsa; Ghasemi-Niri, Seyedeh Farnaz; Mozaffari, Shilan; Abdolghaffari, Amir Hossein; Baeeri, Maryam; Navaea-Nigjeh, Mona; Abdollahi, Mohammad

doi:10.3748/wjg.v20.i31.10876

Cited by 24 publications

(16 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The higher classification accuracy results within the voluntary versus forced exercise mice again support that the voluntary exercise model was more vigorous overall. Out of the important taxa shared across both exercise programs, it is known that taxa in the Bacteroidales and Clostridiales orders produce short-chain fatty acids ( 46 ) that protect against obesity and colon cancer ( 47 , 48 ). Lactobacillus species, found to be important only in the forced exercise cohort, also produce short-chain fatty acids such as butyrate and have been shown to be protective against pathogens ( 18 ).…”

Section: Discussionmentioning

confidence: 99%

Moderate Exercise Has Limited but Distinguishable Effects on the Mouse Microbiome

2017

View full text Add to dashboard Cite

The bacteria that live in our gut have a complex yet vital relationship with our health. Environmental factors that influence the gut microbiome are of great interest, as recent research demonstrates that these microbes, mostly bacteria, are important for normal host physiology. Diseases such as obesity, diabetes, inflammatory bowel disease, and colon cancer have also been linked to shifts in the microbiome. Exercise is known to have beneficial effects on these diseases; however, much less is known about its direct impact on the gut microbiome. Our results illustrate that exercise has a moderate but measurable effect on gut microbial communities in mice. These methods can be used to provide important insight into other factors affecting the microbiome and our health.

show abstract

Section: Discussionmentioning

confidence: 99%

Moderate Exercise Has Limited but Distinguishable Effects on the Mouse Microbiome

2017

View full text Add to dashboard Cite

show abstract

“…[49][50][51] In addition, AL-1 in a dose-dependent manner reduced the TNF-α, IL-6, COX-2, MPO, macroscopic score, and DAI levels in colitis mice. 56 In addition, TNF-α was involved in necroptosis pathway of the intestinal cell death, either through a number of protein kinases that induced membrane depolarization or by induced NF-κB activation. 56 In addition, TNF-α was involved in necroptosis pathway of the intestinal cell death, either through a number of protein kinases that induced membrane depolarization or by induced NF-κB activation.…”

Section: Discussionmentioning

confidence: 99%

Effects of alpha lipoic acid and its derivative “andrographolid‐lipoic acid‐1” on ulcerative colitis: A systematic review with meta‐analysis of animal studies

Moeinian

Abdolghaffari

Nikfar

et al. 2018

J of Cellular Biochemistry

Self Cite

View full text Add to dashboard Cite

We aimed to review and meta‐analyze the inflammatory and oxidative factors following alpha lipoic acid (ALA) and its derivative “andrographolid‐lipoic acid‐1” (AL‐1) in ulcerative colitis (UC). ALA plays an important role in scavenging intracellular radicals and inflammatory elements. AL‐1 is found in herbal medicines with potent anti‐inflammatory properties. Data were collected from the Google Scholar, PubMed, Scopus, Evidence‐based medicine/clinical trials, and Cochrane library database until 2017, which finally resulted in 22 animal studies (70 rats and 162 mice). The beneficial effects of ALA or AL‐1 on the most important parameters of UC were reviewed; also, studies were considered separately in mice and rats. Administration of ALA and AL‐1 significantly reduced the tumor necrosis factor‐α level compared with the controls, while data were not noteworthy in the meta‐analysis (mean differences = −18.57 [95% CI = −42.65 to 5.51], P = 0.13). In spite of insignificant decrease in meta‐analysis outcomes (differences = 6.92 [95% CI = −39.33 to 53.16], P = 0.77), a significant reduction in myeloperoxidase activity was shown following ALA or AL‐1 treatment compared with the controls. Despite significant differences in each study, we had to exclude some studies to homogenize data for meta‐analyzing as they showed insignificant results. Interleukin 6, cyclooxygenase‐2, glutathione, malondialdehyde, superoxide dismutase, histopathological score, macroscopic and microscopic scores, disease activity index, body weight change, and colon length were also reviewed. Most studies have emphasized on significant positive effects of ALA and AL‐1. Comprehensive clinical trials are obligatory to determine the precious position of ALA or AL‐1 in the management of UC.

show abstract

“…Even the beneficial effect of probiotics in pouchitis seems to be related to the enhancement of mucosal barrier function [ 138 ]. Another potential mechanism of action is the restoration of butyrate-producing bacteria: UC patients have reduced bacterial species like Faecalibacterium prausnitzii [ 133 , 139 ] and supplementation with butyrate-producing species or probiotics along with preformed butyrate showed efficacy in experimental models [ 140 , 141 ].…”

Section: Permeability-oriented Therapiesmentioning

confidence: 99%

Intestinal Permeability in Inflammatory Bowel Disease: Pathogenesis, Clinical Evaluation, and Therapy of Leaky Gut

Michielan

D’Incà

2015

Mediators of Inflammation

504

371

View full text Add to dashboard Cite

The pathogenesis of inflammatory bowel disease (IBD) is multifactorial with data suggesting the role of a disturbed interaction between the gut and the intestinal microbiota. A defective mucosal barrier may result in increased intestinal permeability which promotes the exposition to luminal content and triggers an immunological response that promotes intestinal inflammation. IBD patients display several defects in the many specialized components of mucosal barrier, from the mucus layer composition to the adhesion molecules that regulate paracellular permeability. These alterations may represent a primary dysfunction in Crohn's disease, but they may also perpetuate chronic mucosal inflammation in ulcerative colitis. In clinical practice, several studies have documented that changes in intestinal permeability can predict IBD course. Functional tests, such as the sugar absorption tests or the novel imaging technique using confocal laser endomicroscopy, allow an in vivo assessment of gut barrier integrity. Antitumor necrosis factor-α (TNF-α) therapy reduces mucosal inflammation and restores intestinal permeability in IBD patients. Butyrate, zinc, and some probiotics also ameliorate mucosal barrier dysfunction but their use is still limited and further studies are needed before considering permeability manipulation as a therapeutic target in IBD.

show abstract

Beneficial effect of butyrate,Lactobacillus caseiand L-carnitine combination in preference to each in experimental colitis

Abstract: The present combination is a suitable mixture in control of experimental colitis and should be trialed in the clinical setting.

Cited by 24 publications

References 45 publications

Moderate Exercise Has Limited but Distinguishable Effects on the Mouse Microbiome

Moderate Exercise Has Limited but Distinguishable Effects on the Mouse Microbiome

Effects of alpha lipoic acid and its derivative “andrographolid‐lipoic acid‐1” on ulcerative colitis: A systematic review with meta‐analysis of animal studies

Intestinal Permeability in Inflammatory Bowel Disease: Pathogenesis, Clinical Evaluation, and Therapy of Leaky Gut

Contact Info

Product

Resources

About