Beneficial Effect of Bezafibrate on Primary Sclerosing Cholangitis (Three Case Reports)

Factors predictive of the efficacy of bezafibrate therapy in patients with primary sclerosing cholangitis

“…The efficacy of bezafibrate for PSC has been reported by several case series, and this drug was prescribed for up to 20% of PSC patients in Japan . We compared the efficacy of bezafibrate with that of UDCA, which was most frequently prescribed for PSC in Japan .…”

“…Bezafibrate is a lipid‐lowering drug that has the side‐effects of lowering the serum levels of hepatobiliary enzymes . Several case reports and series have reported improvement of liver function tests in patients with PSC using this drug . Bezafibrate is used as an adjuvant treatment to postpone or obviate the need for liver transplantation.…”

Prospective study of bezafibrate for the treatment of primary sclerosing cholangitis

“…Bezafibrate is used to treat dyslipidemia, and is known to be effective in patients with primary biliary cirrhosis (PBC), a chronic cholestatic disease . Several case reports and case series have evaluated the efficacy of bezafibrate in treatment of PSC . However, all studies were retrospective in nature.…”

Brazilian society of hepatology recommendations for the diagnosis and management of autoimmune diseases of the liver

“…Bezafibrate has been successfully used as a pharmacological alternative in the PSC in a few cases reported in the literature, so that there is insufficient evidence to recommend its use (88,89) . Corticosteroids and other immunosuppressive agents are not recommended for the treatment of PSC, except in cases of PSC with features resembling AIH, the so called "AIH/ PSC overlap syndrome" (68) In this context, the combined regimen with prednisone and azathioprine is indicated, typically in association with UDCA.…”