Beneficial Effect of Aspirin on Renal Function Post-Cardiopulmonary Bypass

Gerrah, Rabin; Izhar, Uzi

doi:10.1177/021849230301100407

Cited by 8 publications

(23 citation statements)

References 19 publications

(18 reference statements)

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“…A total of 3922 patients from 12 RCTs and 30 893 patients coming from 28 observational studies met our inclusion criteria and were included in the meta‐analysis. Characteristics of the studies are presented in Tables and .…”

Section: Resultsmentioning

confidence: 99%

“…Sixteen observational studies reported 30‐day mortality with an aggregate of 27 944 patients. Pooling the results of the observational studies, preoperative aspirin showed a significant decrease in postoperative mortality by 32% (OR 0.68; 95%CI 0.55‐0.85; P = 0.0004; I 2 = 23%; P heterogeneity = 0.19) (Figure ).…”

Section: Resultsmentioning

confidence: 99%

“…Pooling the results of both RCTs and observational studies, preoperative aspirin showed a significant decrease in postoperative mortality by 29% (OR 0.71; 95%CI 0.6‐0.84; P = 0.0001; I 2 = 7%; P heterogeneity = 0.36). A total of 31 306 patients have been pooled to assess 30‐day mortality of which 93.03% underwent CABG with or without heart valve surgery (Figure ).…”

Section: Resultsmentioning

confidence: 99%

“…Nineteen observational studies reported PRBC transfusion rates. The analysis was based on the results from 18 392 patients.…”

Section: Resultsmentioning

confidence: 99%

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The use of preoperative aspirin in cardiac surgery: A systematic review and meta-analysis

et al. 2017

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Preoperative aspirin increases the risk for postoperative bleeding. However, this did not result in an increased need for chest re-exploration and did not increase the rates of PRBC transfusion when preoperative low-dose (≤160 mg/d) aspirin was administered. Aspirin at any dose is associated with decreased mortality and AKI and low-dose aspirin (≤160 mg/d) decreases the incidence of perioperative MI.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Nineteen observational studies reported PRBC transfusion rates. The analysis was based on the results from 18 392 patients.…”

Section: Resultsmentioning

confidence: 99%

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The use of preoperative aspirin in cardiac surgery: A systematic review and meta-analysis

et al. 2017

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“…In online supplementary appendix 1, we provide three lines of evidence to support the hypothesis that perioperative aspirin use reduces the risk of postoperative AKI. [7][8][9][10][11][12][13][14][15] The pathways where aspirin may mitigate AKI are presented in figure 1. 16 We are conducting the Perioperative Ischaemia Evaluation-2 trial (POISE-2).…”

Section: Introductionmentioning

confidence: 99%

Aspirin and clonidine in non-cardiac surgery: acute kidney injury substudy protocol of the Perioperative Ischaemic Evaluation (POISE) 2 randomised controlled trial

et al. 2014

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IntroductionPerioperative Ischaemic Evaluation-2 (POISE-2) is an international 2×2 factorial randomised controlled trial of low-dose aspirin versus placebo and low-dose clonidine versus placebo in patients who undergo non-cardiac surgery. Perioperative aspirin (and possibly clonidine) may reduce the risk of postoperative acute kidney injury (AKI).Methods and analysisAfter receipt of grant funding, serial postoperative serum creatinine measurements began to be recorded in consecutive patients enrolled at substudy participating centres. With respect to the study schedule, the last of over 6500 substudy patients from 82 centres in 21 countries were randomised in December 2013. The authors will use logistic regression to estimate the adjusted OR of AKI following surgery (compared with the preoperative serum creatinine value, a postoperative increase ≥26.5 μmol/L in the 2 days following surgery or an increase of ≥50% in the 7 days following surgery) comparing each intervention to placebo, and will report the adjusted relative risk reduction. Alternate definitions of AKI will also be considered, as will the outcome of AKI in subgroups defined by the presence of preoperative chronic kidney disease and preoperative chronic aspirin use. At the time of randomisation, a subpopulation agreed to a single measurement of serum creatinine between 3 and 12 months after surgery, and the authors will examine intervention effects on this outcome.Ethics and disseminationThe authors were competitively awarded a grant from the Canadian Institutes of Health Research for this POISE-2 AKI substudy. Ethics approval was obtained for additional kidney data collection in consecutive patients enrolled at participating centres, which first began for patients enrolled after January 2011. In patients who provided consent, the remaining longer term serum creatinine data will be collected throughout 2014. The results of this study will be reported no later than 2015.Clinical Trial Registration NumberNCT01082874.

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