Beneficial Effect of Artificial Tears Made with Autologous Serum in Patients with Keratoconjunctivitis Sicca

Fox, Robert I.; Chan, Raymond K. H.; Michelson, Joseph B.; Belmont, Jonathan B.; Michelśon, Paul E.

doi:10.1002/art.1780270415

Cited by 283 publications

(192 citation statements)

References 7 publications

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“…5,6 Topical autologous serum drops are used clinically and have been found to be beneficial for severe dry eyes and PED. 1,[5][6][7][8] To our knowledge, no in vivo studies have been published on the use of allogeneic serum to treat PED. However, in vitro studies showed allogeneic 6 and xenogeneic 5 serum accelerated the migration and proliferation of human corneal epithelium.…”

Section: Discussionmentioning

confidence: 99%

Allogeneic serum eye drops for the treatment of persistent corneal epithelial defect

et al. 2008

Eye

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Section: Discussionmentioning

confidence: 99%

Allogeneic serum eye drops for the treatment of persistent corneal epithelial defect

et al. 2008

Eye

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“…3,5,9 For instance, a recent meta-analysis estimated that topical lubricants provide an overall improvement that is no greater than 25% from baseline, while topical CsA achieved improvement in only 10/16 (62%) patients. 10,11 Recently, borrowing from the experience of patients with severe DES in Sjö gren's disease, 12,13 treatment with autologous serum eye drops has been proposed to treat refractory keratoconjuntivitis sicca in GVHD patients with good results, demonstrating that serum is safe and effective in the majority of patients after 4 weeks of treatment. [14][15][16] Autologous serum is rich in several growth factors, vitamins and fibronectin, all active elements involved in maintaining corneal and conjunctival integrity.…”

Section: Introductionmentioning

confidence: 99%

Autologous platelet lysate for treatment of refractory ocular GVHD

Pezzotta

Fante

Scudeller

et al. 2012

Bone Marrow Transplant

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Current treatment of ocular GVHD (oGVHD), represented by systemic immunosuppressive regimens and local therapies (mainly artificial tears and corticosteroids), gives unsatisfactory results. We investigated the safety and efficacy of autologous plasma rich in PDGFs to treat oGVHD unresponsive to standard medications. A total of 23 patients with refractory oGVHD (grade II-IV) unresponsive to standard therapy were treated with autologous plasma rich in PDGFs eye drops (PRGD) four times/day for 6 months. Symptoms and signs (best visual acuity, Schirmer's test and tear break up time (TBUT), evaluation of the anterior segment and fluorescein and lissamine staining) were always assessed by the same ophthalmologist. Patients were defined as 'responders' when showing improvement for total complaints and at least one sign. At 30 days of treatment, 17 patients (73.9%) were classified as responders. The symptom that improved most was photophobia (improved in 19 patients, 82.6%). TBUT improved in 20 patients (86.9%) and anterior segment score in 19 patients (82.6%). Response was maintained over time. No serious adverse events occurred. PRGD proved to be safe and effective in treating oGVHD and may be a valid treatment option from the early stages of the disease to avoid irreversible ocular damage.

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“…(4) Bióloga do Laboratório Oftalmolab. (5) Oftalmologista -Pós-graduando(a) nível doutorado do Departamento de Oftalmologia da UNIFESP/EPM. (6) Livre-Docente do Departamento de Oftalmologia da UNIFESP/EPM.…”

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“…São Paulo (SP) CEP 04524-020. E-mail: coftalmo@uol.com.br Ana Luisa Höfling-Lima (1) Acácio Souza Lima (2) José Antonio Batistoso (3) Débora Kawamura (4) Maria Regina Catai Chalita (5) Leandro Siqueira Alves (5) Michel Eid Farah (6) RESUMO INTRODUÇÃO Na literatura oftalmológica encontramos casos descritos de infecções oculares bacterianas transmitidas por colírios contaminados 1,2 . A manutenção da esterilização dos medicamentos usados topicamente é importante visto que em muitas situações pode haver uma modificação da defesa natural do próprio paciente 3,4 .…”

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Contaminação de frascos de colírios de soro autólogo

Höfling-Lima

Lima

Batistoso³

et al. 2001

Arq. Bras. Oftalmol.

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Na literatura oftalmológica encontramos casos descritos de infecções oculares bacterianas transmitidas por colírios contaminados 1,2 . A manutenção da esterilização dos medicamentos usados topicamente é importante visto que em muitas situações pode haver uma modificação da defesa natural do próprio paciente 3, 4 .O colírio de sangue autólogo é utilizado para o tratamento de doenças como a ceratoconjuntivite sicca 5-8 , e em geral pacientes que fazem uso deste tipo de medicação possuem alterações de superfície ocular, o que pode predispor a possíveis infecções oculares [7][8] .Outros estudos que analisaram a contaminação de colírios anestésicos associados ou não ao corante vital fluoresceína 4 , ou colírios de uso geral 3,9 , verificaram que existe a possibilidade de contaminação tanto por microorganismos Gram positivos como por microrganismos Gram negativos.Este estudo tem como objetivo avaliar a contaminação de resíduos em frascos de colírios de soro autólogo após o uso tópico. MÉTODOSForam avaliados os resíduos de 127 frascos de colírios de sangue autólogo 100% manipulados pelo laboratório Oftalmolab no período de Dezembro de 1998 a Abril de 2000.

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Beneficial Effect of Artificial Tears Made with Autologous Serum in Patients with Keratoconjunctivitis Sicca

Cited by 283 publications

References 7 publications

Allogeneic serum eye drops for the treatment of persistent corneal epithelial defect

Allogeneic serum eye drops for the treatment of persistent corneal epithelial defect

Autologous platelet lysate for treatment of refractory ocular GVHD

Contaminação de frascos de colírios de soro autólogo

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