Beneficial effect of Ageratum conyzoides Linn (Asteraceae) upon inflammatory response induced by carrageenan into the mice pleural cavity

Mello, Silvana Virginia Gagliotti Vigil de; Rosa, Júlia Salvan da; Facchin, B.; Luz, Ana Beatriz Gobbo; Vicente, Geison; Faqueti, Larissa; Rosa, Daniela W.; Biavatti, Maique W.; Fröde, Tânia Sílvia

doi:10.1016/j.jep.2016.09.003

Cited by 21 publications

(14 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ageratum conyzoides is widely used in Brazil as anti-inflammatory, which was corroborated by the recent study published by Mello et al. ( 2016 ), who studied the mechanism of action of the extract and isolated compounds from this plant. This extract inhibited leukocyte influx and decreased pro-inflammatory mediators, like NF-κB.…”

Section: Mechanisms Of Anti-inflammatory Actions Of Brazilian Plants mentioning

confidence: 54%

“…The crude extract, its fractions and isolated compounds from Ageratum conyzoides L. (Asteraceae) aerial parts are able to reduce the production of IL-6, TNF-α and INF-γ (Mello et al. 2016 ). The same mechanism was described for the stem bark extract of Anacardium occidentale L. (Anacardiaceae), which is able to inhibit the production of IL-6 and TNF-α for a period of 24 h (Olajide et al.…”

Section: Mechanisms Of Anti-inflammatory Actions Of Brazilian Plants mentioning

confidence: 99%

“…The crude extract of the leaves, their fractions and the isolated compounds benzopyrone and eupalestin significantly reduced the flow of leukocytes and the nitric oxide metabolites, as well as inhibited other inflammatory mediators (Mello et al. 2016 ).…”

Section: Mechanisms Of Anti-inflammatory Actions Of Brazilian Plants mentioning

confidence: 99%

See 2 more Smart Citations

Brazilian medicinal plants with corroborated anti-inflammatory activities: a review

Ribeiro

Arruda

El-Salam

et al. 2018

Pharmaceutical Biology

101

View full text Add to dashboard Cite

Context: Inflammatory disorders are common in modern life, and medicinal plants provide an interesting source for new compounds bearing anti-inflammatory properties. In this regard, Brazilian medicinal plants are considered to be a promising supply of such compounds due to their great biodiversity.Objectives: To undertake a review on Brazilian medicinal plants with corroborated anti-inflammatory activities by selecting data from the literature reporting the efficacy of plants used in folk medicine as anti-inflammatory, including the mechanisms of action of their extracts and isolated compounds.Methods: A search in the literature was undertaken by using the following Web tools: Web of Science, SciFinder, Pub-Med and Science Direct. The terms ‘anti-inflammatory’ and ‘Brazilian medicinal plants’ were used as keywords in search engine. Tropicos and Reflora websites were used to verify the origin of the plants, and only the native plants of Brazil were included in this review. The publications reporting the use of well-accepted scientific protocols to corroborate the anti-inflammatory activities of Brazilian medicinal plants with anti-inflammatory potential were considered.Results: We selected 70 Brazilian medicinal plants with anti-inflammatory activity. The plants were grouped according to their anti-inflammatory mechanisms of action. The main mechanisms involved inflammatory mediators, such as interleukins (ILs), nuclear factor kappa B (NF-κB), prostaglandin E2 (PGE2), cyclooxygenase (COX) and reactive oxygen species (ROS).Conclusions: The collected data on Brazilian medicinal plants, in the form of crude extract and/or isolated compounds, showed significant anti-inflammatory activities involving different mechanisms of action, indicating Brazilian plants as an important source of anti-inflammatory compounds.

show abstract

Section: Mechanisms Of Anti-inflammatory Actions Of Brazilian Plants mentioning

confidence: 54%

Section: Mechanisms Of Anti-inflammatory Actions Of Brazilian Plants mentioning

confidence: 99%

See 1 more Smart Citation

Brazilian medicinal plants with corroborated anti-inflammatory activities: a review

Ribeiro

Arruda

El-Salam

et al. 2018

Pharmaceutical Biology

101

View full text Add to dashboard Cite

show abstract

“…In a similar study, A. conyzoides extract was shown to inhibit leukocyte influx and protein concentration of the exudate, as well as reducing the levels of several pro‐inflammatory mediators. Therefore, these authors hypothesized that the anti‐inflammatory action of A. conyzoides may be due to the inhibition of p65, NF‐κB, and MAPK activation by the isolated compounds . Although this research is providing potential anti‐inflammatory properties of A. conyzoides , further research is required in human clinical studies.…”

Section: Discussionmentioning

confidence: 99%

Ageratum conyzoides L. inhibits 5‐alpha‐reductase gene expression in human prostate cells and reduces symptoms of benign prostatic hypertrophy in otherwise healthy men in a double blind randomized placebo controlled clinical study

et al. 2017

View full text Add to dashboard Cite

A double-blind, randomized, placebo-controlled clinical trial assessed the efficacy and safety of Ageratum conyzoides in treating benign prostatic hypertrophy (BPH). In this study, 109 men with medically diagnosed BPH, aged 41-76 years, were administered the investigational product, A. conyzoides extract at a dose of 250 mg/d or placebo, q.d. for 12 weeks. The primary outcome measures were the International Prostate Symptom Score (IPSS), daily urinary frequency and safety evaluations. The secondary outcome measures were testosterone, dihydrotestosterone, oestradiol, sex hormone binding globulin (SHBG), Dehydroepiandrosterone sulfate (DHEA-S) and cortisol levels, and prostate specific antigen (PSA), lipids, blood glucose, the Aging Male's Symptom (AMS) Score and sexual function assessed by Derogatis Interview for Sexual Functioning-Self Report (DISF-SR). The effect of A. conyzoides L extract on gene expression of 5-alpha-reductase in human prostate cells was also investigated to elucidate a potential mechanism of action. The clinical study, showed a significant reduction in total IPSS score (p < 0.01) and day- and night-time urinary frequency (P < 0.01) over time after treatment with A. conyzoides. Steroid hormones, SHBG, PSA levels, lipids, and blood glucose remained within healthy reference range in both groups. There were no changes in AMS or DISF-SR in either group. Gene arrays demonstrated that A. conyzoides extract was effective in reducing the expression of mRNA coding for 5-alpha-reductase types 2 and 1 in human prostate epithelial cells. The overall results indicate that A. conyzoides may be an effective treatment for reducing symptoms of BPH in healthy men, in part, through inhibition of 5-alpha-reductase enzyme activity. © 2017 BioFactors, 43(6):789-800, 2017.

show abstract

“…Marques Neto et al, (1988) reported analgesic activity of an aqueous extract of the whole plant of A. conyzoides in 66% of arthritic patients without side effects in clinical trials. Mello et al (2016) reported a reduction in inflammatory response in mice pleural cavity using A. conyzoides extracts. Tandon et al (1994) have reported the anti-inflammatory activities from hydroalcoholic extract (leaves) in rats.…”

Section: Analgesic Effectsmentioning

confidence: 99%

Phytochemical constituents and ethnopharmacological properties of Ageratum conyzoides L.

Yadav

Ganie

Singh

et al. 2019

Phytotherapy Research

View full text Add to dashboard Cite

Ageratum conyzoides L. (Asteraceae) is an invasive aromatic herb with immense therapeutic importance. The herb is distributed in tropical and subtropical regions. A. conyzoides has imparted numerous ethnomedicinal uses because it has been used to cure various ailments that include leprosy, skin disorders, sleeping sickness, rheumatism, headaches, dyspnea, toothache, pneumonia and many more. A number of phytoconstituents have been scrutinized such as alkaloids, flavonoids, terpenes, chromenes, and sterols from almost every part of this plant. These phytoconstituents have shown diverse pharmacological properties including antimicrobial, anti‐inflammatory, analgesic, antioxidant, anticancer, antiprotozoal, antidiabetic, spasmolytic, allelopathy, and many more. The plant A. conyzoides has provided a platform for doing pharmaceutical and toxicological research in order to isolate some promising active compounds and authenticate their safety in clinical uses. A. conyzoides provides principal information for advanced studies in the field of pharmaceutical industries and agriculture. Present review article describes the cytogenetics, ethnobotany, phytochemistry, pharmacology, and toxicological aspects of A. conyzoides.

show abstract

Beneficial effect of Ageratum conyzoides Linn (Asteraceae) upon inflammatory response induced by carrageenan into the mice pleural cavity

Cited by 21 publications

References 40 publications

Brazilian medicinal plants with corroborated anti-inflammatory activities: a review

Brazilian medicinal plants with corroborated anti-inflammatory activities: a review

Ageratum conyzoides L. inhibits 5‐alpha‐reductase gene expression in human prostate cells and reduces symptoms of benign prostatic hypertrophy in otherwise healthy men in a double blind randomized placebo controlled clinical study

Phytochemical constituents and ethnopharmacological properties of Ageratum conyzoides L.

Contact Info

Product

Resources

About