Beneficial associations of low and large doses of leisure time physical activity with all-cause, cardiovascular disease and cancer mortality: a national cohort study of 88,140 US adults

Abstract

BackgroundEvidence on the role of very low or very high volumes of leisure time physical activity (PA) on the risk of all-cause and cause-specific mortality is limited. We aimed to examine the associations of different levels of leisure time PA with the risk of all-cause, cardiovascular disease (CVD) and cancer-specific mortality.MethodsData were from 12 waves of the National Health Interview Surveys (1997–2008) linked to the National Death Index records through 31 December 2011. A total of 88 140 eligible participants aged 40–85 years were included.ResultsCompared with inactive individuals, those performing 10–59 min/week of PA had 18% lower risk of all-cause mortality (hazard ratio (HR): 0.82, 95% confidence interval (CI): 0.72–0.95). Those who reported 1–2 times (150–299 min/week) the recommended level of leisure time PA had 31% (HR: 0.69, 95%CI: 0.63–0.75) reduced risk of all-cause mortality. Importantly, the continued benefits were observed among those performing leisure time PA 10 or more times (≥1500 min/week) the recommended minimum level (HR: 0.54, 95% CI: 0.45–0.64). For 10–59, 150–299 and ≥1500 min/week of PA, the corresponding HRs (95% CIs) for CVD-specific mortality were 0.88 (0.67–1.17), 0.63 (0.52–0.78) and 0.67 (0.45–0.99), respectively: for cancer-specific mortality were 0.86 (0.66–1.11), 0.76 (0.64–0.89) and 0.53 (0.39–0.73), respectively. In addition, there was a larger reduction in all-cause and cause-specific mortality for vigorous vs. moderate intensity PA.ConclusionsWe found that beneficial association between leisure time PA and mortality starts from a low dose. Doing more vigorous exercise could lead to additional health benefits.

Exercise as A Potential Therapeutic Target for Diabetic Cardiomyopathy: Insight into the Underlying Mechanisms

“…Similar studies have shown that long-term exercisecould be an effective adjuvant treatment strategy against doxorubicin-related cardiac toxicity [56,84]. Recently, despite the limitations of a clinical human trial, the American Heart Association has suggested that personalized exercise therapy could be considered as a part of precision medicine for cancer patients to improve cardiovascular mortality [116,117]. Based on these recommendations, exercise may be presumed to influence an improved outcome in patients with DCM.…”

Exercise as A Potential Therapeutic Target for Diabetic Cardiomyopathy: Insight into the Underlying Mechanisms

“…Similar studies have shown that long-term exercise could be an effective adjuvant treatment strategy against doxorubicin-related cardiac toxicity [92,110]. Recently, despite the limitations of a clinical human trial, the American Heart Association has suggested that personalized exercise therapy could be considered as a part of precision medicine for cancer patients to improve cardiovascular mortality [138,139]. Based on these recommendations, exercise may be presumed to influence an improved outcome in patients with DCM.…”

Seven days in medicine: 13-19 March 2019

“…Walking or gardening for 10 minutes to an hour each week was associated with a lower risk of death from cardiovascular disease, cancer, or any cause, in a large observational study published in the British Journal of Sports Medicine 1. Higher amounts of activities or more vigorous ones such as running, cycling, or competitive sports were associated with additional health benefits that were not outweighed by the risks of participating, the authors said.…”