Beneficial antioxidant effects of Coenzyme Q10 on reproduction

Carneiro, María Fernanda Hornos; Colaiácovo, Mónica P.

doi:10.1016/bs.vh.2022.10.004

Cited by 5 publications

(2 citation statements)

References 92 publications

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“…Coenzyme Q10 is a fat-soluble ubiquinone with intracellular antioxidant activity synthesized endogenously from phenylalanine (benzoquinone ring) and mevalonic acid (responsible for isoprenoid units) but it can also be provided (in a minor part) from the diet. In the mitochondrial respiratory chain, it is responsible for electron transport from complex I and II to complex III [145,146]. Coenzyme Q10 was found to play an important role as an antioxidant in plasma lipoproteins, where it also regenerates the active form of vitamin E. When orally administered to mice [147] and rabbits [148], coenzyme Q10 showed a significant anti-atherosclerotic effect.…”

Section: Nrf2 Modulation By Natural Compoundsmentioning

confidence: 99%

Modulation of NRF2/KEAP1 Signaling in Preeclampsia

Tossetta

Fantone

Piani

et al. 2023

Cells

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Placentation is a key and tightly regulated process that ensures the normal development of the placenta and fetal growth. Preeclampsia (PE) is a hypertensive pregnancy-related disorder involving about 5–8% of all pregnancies and clinically characterized by de novo maternal hypertension and proteinuria. In addition, PE pregnancies are also characterized by increased oxidative stress and inflammation. The NRF2/KEAP1 signaling pathway plays an important role in protecting cells against oxidative damage due to increased reactive oxygen species (ROS) levels. ROS activate NRF2, allowing its binding to the antioxidant response element (ARE) region present in the promoter of several antioxidant genes such as heme oxygenase, catalase, glutathione peroxidase and superoxide dismutase that neutralize ROS, protecting cells against oxidative stress damages. In this review, we analyze the current literature regarding the role of the NRF2/KEAP1 pathway in preeclamptic pregnancies, discussing the main cellular modulators of this pathway. Moreover, we also discuss the main natural and synthetic compounds that can regulate this pathway in in vivo and in vitro models.

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Section: Nrf2 Modulation By Natural Compoundsmentioning

confidence: 99%

Modulation of NRF2/KEAP1 Signaling in Preeclampsia

Tossetta

Fantone

Piani

et al. 2023

Cells

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“…The impaired mitochondrial performance created by suboptimal CoQ10 availability can drive age-associated oocyte deficits, causing infertility [ 23 ]. CoQ10 is thought to be able to delay oocyte aging and prevent the decline in reproductive function [ 24 ]. Additionally, CoQ10 increases the number of cumulus cells surrounding the oocyte, reducing oocyte apoptosis and increasing developmental competence, ultimately improving reproductive performance [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

The Efficacy and Safety of GF101 and Its Antioxidant Effect on In Vitro Fertilization Outcomes: A Double-Blind, Non-Inferiority, Randomized, Controlled Trial with Coenzyme Q10

Shin,

Yoon,

Kim

et al. 2024

Antioxidants

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(1) Background: Oxidative stress adversely affects fertility by impairing oocyte fertilization potential, primarily due to meiotic segregation errors and cohesion loss. Superoxide dismutase (SOD) and Coenzyme Q10 (CoQ10) are prominent antioxidants known to mitigate oxidative damage. (2) Methods: This study recruited 86 patients undergoing in vitro fertilization (IVF) at a single center for a 12-week, randomized, double-blind, active-comparator-controlled trial. Participants were allocated into two groups: one receiving CoQ10 as an antioxidant (the CoQ10 group) and the other receiving GF Bacillus antioxidative enzyme SOD (the GF101 group). The primary endpoints were changes in serum oxidative markers (SOD and catalase) and IVF outcomes, including clinical pregnancy, miscarriage, and live birth rates. Follicular fluid (FF) SOD and catalase concentrations on the day of retrieval, the metaphase II (MII) oocyte rate, the fertilization rate, and lipid profiles were measured. (3) Results: Initially, 86 patients were enrolled, with 65 completing the protocol (30 in the GF101 group and 34 in the CoQ10 group). There were no significant differences between the GF101 and CoQ10 groups in serum SOD (p = 0.626) and catalase levels (p = 0.061) over 12 weeks. However, within the GF101 group, a significant increase in serum catalase from baseline to 12 weeks was observed (p = 0.004). The non-inferiority analysis for IVF outcomes indicated risk differences in the clinical pregnancy rate, live birth rate, and miscarriage rate of −6.27% (95% CI: −30.77% to 18.22%), −1.18% (95% CI: −25.28% to 22.93%), and −13.49% (95% CI: −41.14% to 14.15%), respectively, demonstrating non-inferiority for the GF101 group. Furthermore, the GF101 group experienced significant reductions in total cholesterol (p = 0.006) and low-density lipoprotein (LDL) levels (p = 0.009) in intra-group comparisons, with both groups exhibiting comparable safe profiles. (4) Conclusions: GF101 may be non-inferior to CoQ10 in treating infertility in women and potentially offers additional benefits for women with dyslipidemia.

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Antioxidants and Fertility in Women with Ovarian Aging: A Systematic Review and Meta-Analysis

Shang,

Song,

et al. 2024

Advances in Nutrition

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Beneficial antioxidant effects of Coenzyme Q10 on reproduction

Cited by 5 publications

References 92 publications

Modulation of NRF2/KEAP1 Signaling in Preeclampsia

Modulation of NRF2/KEAP1 Signaling in Preeclampsia

The Efficacy and Safety of GF101 and Its Antioxidant Effect on In Vitro Fertilization Outcomes: A Double-Blind, Non-Inferiority, Randomized, Controlled Trial with Coenzyme Q10

Antioxidants and Fertility in Women with Ovarian Aging: A Systematic Review and Meta-Analysis

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