Benefice and pitfall of direct oral anticoagulants in very high-risk myeloproliferative neoplasms

Adrenal insufficiency revealing bilateral adrenal hemorrhage related to JAK2 V617F-positive essential thrombocythemia: about two cases

“…DOACs are now increasingly being used, especially since the high-quality evidence demonstrating their safety and efficacy for cancer-associated venous thromboembolism [16][17][18]. Specific data in the context of MPNs are still scarce, but first evidence suggested that DOACs are effective in preventing thrombosis recurrence, with similar efficacy as VKA, except for high-risk patients in which incidence of arterial thrombosis appears to be higher on low-dose DOACs [19][20][21][22]. To our knowledge, we report here the first cases of bilateral adrenal hemorrhage occurring in the context of MPN in patients who were on DOACs for another indication (atrial fibrillation).…”