Benefical effects of lycopene against contrast medium-induced oxidative stress, inflammation, autophagy, and apoptosis in rat kidney

Büyüklü, Mutlu; Kandemır, F. M.; Özkaraca, Mustafa; Set, Turan; Bakirci, EM; Topal, Ergün; İleritürk, Mustafa; Türkmen, Kültiğin

doi:10.1177/0960327114542964

Cited by 55 publications

(60 citation statements)

References 37 publications

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“…Additionally, we found that lycopene ameliorated inflammation as manifested by reduction of IL-1b, IL-2, IL-6 and TNF-a and by increase IL-10 levels in blood, similarly to other groups [50,51]. It has also been reported that lycopene displays anti-inflammatory effects in different models [52,53]. Accordingly, in the present study administration of lycopene decreased serum cytokine levels concomitantly with a decrease in testes inflammatory response (as reported in a previous study of our group).…”

Section: Discussionsupporting

confidence: 79%

Lycopene protects against acute zearalenone-induced oxidative, endocrine, inflammatory and reproductive damages in male mice

Boeira

Funck

Filho

et al. 2015

Chemico-Biological Interactions

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Section: Discussionsupporting

confidence: 79%

Lycopene protects against acute zearalenone-induced oxidative, endocrine, inflammatory and reproductive damages in male mice

Boeira

Funck

Filho

et al. 2015

Chemico-Biological Interactions

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“…14 Our previous work demonstrated a significant increase in cleaved caspase-3 as a marker of apoptosis in rats with CN compared with a control group. 15 The present study showed similar results regarding increased levels of cleaved caspase-3 in a different model of CN, compared with our previous study. 15 Autophagy is a tightly regulated, highly conserved physiologic process that involves recycling cytoplasmic proteins and molecules within autophagolysosomes.…”

Section: Discussionsupporting

confidence: 91%

“…15 The present study showed similar results regarding increased levels of cleaved caspase-3 in a different model of CN, compared with our previous study. 15 Autophagy is a tightly regulated, highly conserved physiologic process that involves recycling cytoplasmic proteins and molecules within autophagolysosomes. 16 Autophagosome generation begins with the induction of several autophagy-related genes, including LC3, ATG-5, and Beclin-1.…”

Section: Discussionsupporting

confidence: 91%

The possible role of interleukin-33 as a new player in the pathogenesis of contrast-induced nephropathy in diabetic rats

et al. 2016

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Introduction: Patients with diabetic kidney disease (DKD) are more prone to contrast-induced nephropathy (CN). Apoptosis and autophagy were found to be essential in the pathogenesis of DKD. Interleukin-33 (IL-33) is a cytokine, but its role in DKD and CN is unknown. As IL-33 is modulated by apoptosis, we aimed to determine the relationship between IL-33 apoptosis and autophagy in DKD with CN. Materials and methods: Thirty male Sprague-Dawley rats were enrolled and randomly allocated into three groups. The first group was comprised of healthy rats (HRs), whereas the other two groups were made up of diabetic rats (DRs) and diabetic rats with CN (DRs þ CN). All groups except the HRs received 50 mg/kg/day of streptozotocin (STZ). The DRs þ CN group was induced by administering 1.5 mg/kg of intravenous radiocontrast dye on the 35th day. Results: We observed increased IL-33 in the kidney tissue following induction of CN in the DRs. The DRs showed moderate immunopositivity, and the DRs þ CN showed severe immunopositivity for caspase-3, cleaved caspase-3, caspase-8, caspase-9, LC3B, and Beclin-1 in tubular cells and glomeruli. The DRs also showed moderate immunopositivity in tubular cells, and the DRs þ CN group showed severe immunopositivity for IL-33 in tubular cells. Increased caspase-3 was found in both glomeruli and tubuli; however, we could not demonstrate IL-33 in glomeruli. This could be secondary to inactivation of IL-33 via increased caspase-3 activity. Conclusion: The release of IL-33 from necrotic cells might induce autophagy, which can further balance the effects of increased apoptosis secondary to CN in DKD.

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“…It reduces TNF-α via the receptor of advanced glycation end products which is a member of the immunoglobulin superfamily (Pierine et al, 2014). Lyc significantly improved oxidative stress, inflammation, lipid peroxidation, autophagy, and apoptosis in rats with contrast induced nephrotoxicity (Buyuklu et al, 2015). Mel reduced the oxidative burden, attenuated the chronic inflammation and limited apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Effects of Lycopene Alone or Combined with Melatonin on Methotrexate-Induced Nephrotoxicity in Rats

Oğuz

Koçarslan²,

Tabur³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Methotrexate (Mtx), used for its anticancer and immunsuppresive properties, is known to be a nephrotoxic agent. We aimed to investigate the effects of lycopene (Lyc) alone or combined with melatonin (Mel) on Mtxinduced nephrotoxicity since both of these agents have antioxidant and anti-inflammatory effects. Nephrotoxicity was induced by intraperitoneal administration of methotrexate at a dose of 20 mg/kg. Treatment both with Lyc alone and Lyc combined with Mel provided significant reduction in tumor necrosis factor-alpha, interleukin 1-beta and ceruloplasmin levels in Mtx administered rats. Hovewer, Lyc combined with Mel provided a significant reduction also in NO levels. Hstopathological examination showed that there was an obvious improvement in the degenerative changes compared to Mtx administrated group with the Lyc combined Mel group giving best protection. In conclusion Lyc alone and combined with Mel provided significant improvement against renal damage caused by Mtx, preseumably via antioxidant and anti-inflammatory activities.

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Benefical effects of lycopene against contrast medium-induced oxidative stress, inflammation, autophagy, and apoptosis in rat kidney

Cited by 55 publications

References 37 publications

Lycopene protects against acute zearalenone-induced oxidative, endocrine, inflammatory and reproductive damages in male mice

Lycopene protects against acute zearalenone-induced oxidative, endocrine, inflammatory and reproductive damages in male mice

The possible role of interleukin-33 as a new player in the pathogenesis of contrast-induced nephropathy in diabetic rats

Effects of Lycopene Alone or Combined with Melatonin on Methotrexate-Induced Nephrotoxicity in Rats

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