The conditions that drive vulnerability to HIV infection for young people in Ontario also limit access to resources and result in poorer health outcomes for youth living with and affected by HIV. Synthesized literature that addresses the ways in which the social determinants of health intersect and influence the experiences of youth living with and affected by HIV is limited. This Research to Practice report contextualizes the current demographics and experiences of young people in Ontario, and highlights critical frameworks, interventions, and program features to support working with youth living with and affected by HIV. Furthermore, it recommends evidencebased best practices and strategies, using a critical, antioppressive lens, for youth workers, youth-serving organizations, and frontline staff across Ontario's youth sector to improve wellbeing for youth living with and affected by HIV.