BENDing with Polycomb in pluripotency and cancer

Khan, Abid; Prasanth, Supriya G.

doi:10.1002/bies.202300046

Cited by 1 publication

(3 citation statements)

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“…A possible tumor suppressor, HACE1 has been reported at this locus [72]. These observations strongly suggest that BEND3 may play an important role in cancer development and progression, also supported by a recent study which reports higher BEND3 expression in cancer cells across TCGA database compared with normal cells [13].…”

Section: Discussion and Future Prospectssupporting

confidence: 58%

“…In a recent study, Abid et al compared the expression of PRC2 complex protein EZH2 and BEND3 across all the reported cancers in TCGA database and established a very strong correlation between the mRNA expression of these two. The correlation was even greater in breast cancer and in glioblastoma [13]. Furthermore, it also causes transcriptional repression of p21, a cell-cycle checkpoint protein, and arrests the cell cycle in the G1 or G2 phase, suggesting its possible oncogenic role.…”

Section: Discussion and Future Prospectsmentioning

confidence: 98%

“…TAK-243 is a phase I clinical trial drug for advanced malignancies [12]. Elevated BEND3 expression is also reported in multiple cancer types across The Cancer Genomic Atlas (TCGA) Program [13]. Although the role of BEND3 in cancer progression is still emerging and gaining prominence, nonetheless, the exact mechanism is not yet fully understood.…”

Section: Introductionmentioning

confidence: 99%

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Role of Transcription Factor BEND3 and Its Potential Effect on Cancer Progression

Naiyer

Dwivedi

Singh

et al. 2023

Cancers

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BEND3 is a transcription factor that plays a critical role in the regulation of gene expression in mammals. While there is limited research on the role of BEND3 as a tumor suppressor or an oncogene and its potential role in cancer therapy is still emerging, several studies suggest that it may be involved in both the processes. Its interaction and regulation with multiple other factors via p21 have already been reported to play a significant role in cancer development, which serves as an indication of its potential role in oncogenesis. Its interaction with chromatin modifiers such as NuRD and NoRC and its role in the recruitment of polycomb repressive complex 2 (PRC2) are some of the additional events indicative of its potential role in cancer development. Moreover, a few recent studies indicate BEND3 as a potential target for cancer therapy. Since the specific mechanisms by which BEND3 may contribute to cancer progression are not yet fully elucidated, in this review, we have discussed the possible pathways BEND3 may take to serve as an oncogenic driver or suppressor.

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Section: Discussion and Future Prospectssupporting

confidence: 58%

Section: Discussion and Future Prospectsmentioning

confidence: 98%