In this paper, we investigate how to detect intruders with low latency for Active Authentication (AA) systems with multiple-users. We extend the Quickest Change Detection (QCD) framework to the multiple-user case and formulate the Multiple-user Quickest Intruder Detection (MQID) algorithm. Furthermore, we extend the algorithm to the data-efficient scenario where intruder detection is carried out with fewer observation samples. We evaluate the effectiveness of the proposed method on two publicly available AA datasets on the face modality.