Abstract. In many application domains, it is desirable to meet some user-defined performance requirement while minimizing resource usage and optimizing additional performance parameters. For example, application workflows with realtime constraints may have strict throughput requirements and desire a low latency or response-time. The structure of these workflows can be represented as directed acyclic graphs of coarse-grained application tasks with data dependences. In this paper, we develop a novel mapping and scheduling algorithm that minimizes the latency of workflows that act on a stream of input data, while satisfying throughput requirements. The algorithm employs pipelined parallelism and intelligent clustering and replication of tasks to meet throughput requirements. Latency is minimized by exploiting task parallelism and reducing communication overheads. Evaluation using synthetic benchmarks and application task graphs shows that our algorithm 1) consistently meets throughput requirements even when other existing schemes fail, 2) produces lower-latency schedules, and 3) results in lesser resource usage.