Benchmark dose approach in investigating the relationship between blood metal levels and reproductive hormones: Data set from human study

Baralić, Katarina; Javorac, Dragana; Marić, Đurđica; Đukić-Ćosić, Danijela; Bulat, Zorica; Miljaković, Evica Antonijević; Anđelković, Milena; Antonijević, Biljana; Aschner, Michael; Djordjevic, Aleksandra Buha

doi:10.1016/j.envint.2022.107313

Cited by 18 publications

(9 citation statements)

References 71 publications

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“…Even at low doses, they may induce adverse health effects, particularly in the conditions of long-term exposure that are characteristic of environmental exposure. Adverse effects of environmental exposure to these metal(loid)s were observed on certain parameters of the male reproductive system [ 16 , 17 , 18 , 19 ]. According to the International Agency for Research on Cancer (IARC), As, Cd, chromium (Cr) (VI), nickel (Ni), and some of their compounds are classified as carcinogens to humans (group 1), while inorganic Pb and Pb compounds are classified as a probable human carcinogen (group 2A) [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

“…According to the International Agency for Research on Cancer (IARC), As, Cd, chromium (Cr) (VI), nickel (Ni), and some of their compounds are classified as carcinogens to humans (group 1), while inorganic Pb and Pb compounds are classified as a probable human carcinogen (group 2A) [ 20 ]. In addition, several of these metal(loid)s are recognized as endocrine disruptor chemicals (EDCs) [ 16 , 21 , 22 , 23 , 24 ] that interfere with estrogen and androgen signaling pathways affecting the expression of genes involved in the growth and the secretory function of the prostate gland and contributing to prostate carcinogenesis [ 25 , 26 ]. Although the scanty epidemiologic data available indicate a possible contribution of several individual metal(loid)s to an increased risk of prostate cancer, only a few studies investigated their contribution to the increased PSA levels in presumably healthy men [ 10 , 12 , 13 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

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Environmental Exposure to Metals, Parameters of Oxidative Stress in Blood and Prostate Cancer: Results from Two Cohorts

et al. 2022

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We studied the potential role of exposure to various metal(oid)s (As, Cd, Cr, Hg, Ni, and Pb) in prostate cancer. Two cohorts were established: the Croatian cohort, consisting of 62 cases and 30 controls, and the Serbian cohort, consisting of 41 cases and 61 controls. Blood/serum samples were collected. Levels of investigated metal(oid)s, various parameters of oxidative stress, and prostate-specific antigen (PSA) were determined in collected samples. A comparison of the measured parameters between 103 prostate cancer patients and 91 control men from both Croatian and Serbian cohorts showed significantly higher blood Hg, SOD, and GPx levels and significantly lower serum SH levels in prostate cancer patients than in controls. Correlation analyses revealed the significant relationship between certain parameters of oxidative stress and the concentrations of the measured metal(loid)s, pointing to the possible role of metal(oid)-induced oxidative stress imbalance. Furthermore, a significant inverse relationship was found between the blood Pb and the serum PSA in prostate cancer patients, but when the model was adjusted for the impacts of remaining parameters, no significant association between the serum PSA and the measured parameters was found. The results of the overall study indicate a substantial contribution of the measured metal(loid)s to the imbalance of the oxidant/antioxidant system. Although somewhat conflicting, the results of the present study point to the possible role of investigated metal(oid)s in prostate cancer, especially for Hg, since the obtained relationship was observed for both cohorts, followed by the disturbances in oxidative stress status, which were found to be correlated with Hg levels. Nevertheless, further studies in larger cohorts are warranted to explain and confirm the obtained results.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Environmental Exposure to Metals, Parameters of Oxidative Stress in Blood and Prostate Cancer: Results from Two Cohorts

et al. 2022

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“…Our previously published research confirmed the importance of the idea of using the BMD approach through the use of PROAST software to establish a relationship between the levels of toxic metals determined in the blood of the general male population (dose) and the levels of reproductive hormones: testosterone, follicle-stimulating (FSH) and luteinizing (LH) hormones in the serum of the subjects (response). The result showed the importance of the ratio of cadmium and testosterone and Hg and LH in terms of the risk of disturbances in the levels of the investigated hormones (29). As normal thyroid function is of great importance for the whole human organism (which was mentioned earlier), defining the amount of an agent that can cause a disorder can be useful in order for certain institutions to take measures to reduce exposure to chemicals and improve health.…”

Section: Discussionmentioning

confidence: 78%

“…The European Food Safety Agency (EFSA) foresees the importance of applying this concept in epidemiological studies, but the number of such studies is small (26). In some of our previously published papers, this approach has been successfully used in the interpretation of results from human studies (28,29). Examining the effects of low doses is of great importance because of the properties of endocrine disruptors (toxic metals such as mercury).…”

Section: Introductionmentioning

confidence: 99%

Exposure to mercury and thyroid function: Is there a connection?

Marić¹,

Bonderović²,

Javorac³

et al. 2022

Arhiv za farmaciju

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Mercury (Hg) is one of the most important environmental pollutants with endocrinedisrupting properties. There is little data from epidemiological studies describing the doseresponse relationship between toxic metal levels and hormone levels. The aim of this study was to use the nearest neighbor matching analysis to determine the difference in Hg concentration in healthy/sick subjects with thyroid disease and to use Benchmark modeling to determine the doseresponse relationship between Hg levels in the blood and thyroid-stimulating hormone (TSH) and thyroid hormones in serum. Blood samples were collected and used for Hg measurement using the ICP-MS method, and separated serum was used for hormone analysis. The study showed the existence of a statistically significant difference in Hg levels measured in healthy and sick subjects and the existence of a dose-response relationship between Hg and all measured hormones, with a narrow interval obtained for the Hg-TSH pair. The results of this research support the use of the Benchmark dose approach for the purpose of analyzing data from human studies, and our further research will be focused on examining the impact of low doses on animal models in order to determine more precise effects of low doses on the organism.

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“…The oral reference dose (RfD) is assumed as the threshold value (obtained from US EPA) [55]. The metal values were in line with those found in men exposed to road dust and high pollutants levels [59,60]. The test of the CDI average values calculated for each metal and the p-value obtained by the Poisson correlation were significantly different from zero.…”

Section: Pollutants Adsorptionmentioning

confidence: 76%

Comparison Process of Blood Heavy Metals Absorption Linked to Measured Air Quality Data in Areas with High and Low Environmental Impact

et al. 2022

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Air pollution is a problem shared by the entire world population, and researchers have highlighted its adverse effects on human health in recent years. The object of this paper was the relationship between the pollutants’ concentrations measured in the air and the quantity of pollutant itself inhaled by the human body. The area chosen for the study has a high environmental impact given the significant presence on the territory of polluting activities. The Acerra area (HI) has a waste-to-energy plant and numerous industries to which polluting emissions are attributed. This area has always been the subject of study as the numbers of cancer patients are high. A survey on male patients to evaluate the heavy metals concentrations in the blood was conducted in the two areas and then linked to its values aero-dispersed. Using the air quality data measured by the monitoring networks in two zones, one with high environmental impact (HI) and one with low environmental impact (LI), the chronicle daily intake (CDI) of pollutants inhaled by a single person was calculated. The pollutants considered in this study are PM10 and four heavy metals (As, Cd, Ni, Pb) constituting the typical particulates of the areas concerned. The CDI values calculated for the two zones are significantly higher in the HI zone following the seasonal pollution trend.

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Benchmark dose approach in investigating the relationship between blood metal levels and reproductive hormones: Data set from human study

Cited by 18 publications

References 71 publications

Environmental Exposure to Metals, Parameters of Oxidative Stress in Blood and Prostate Cancer: Results from Two Cohorts

Environmental Exposure to Metals, Parameters of Oxidative Stress in Blood and Prostate Cancer: Results from Two Cohorts

Exposure to mercury and thyroid function: Is there a connection?

Comparison Process of Blood Heavy Metals Absorption Linked to Measured Air Quality Data in Areas with High and Low Environmental Impact

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