Bench-to-bedside review: Nitric oxide in critical illness – update 2008

Hollenberg, Steven M.; Cinel, İsmail

doi:10.1186/cc7706

Cited by 66 publications

(50 citation statements)

References 57 publications

(72 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This overlap in expression and functions is also true for the vertebrate NOS and Rev-erb/ROR orthologs (Raspe et al 2002a,b;Sato et al 2004;Pardee et al 2009;Jobgen et al 2006;Kang et al 2007;Hasegawa 2008;Hollenberg and Cinel 2009;Jetten 2009;Mustafa et al 2009). Examples of overlapping functions in vertebrates include their similar roles in lipid metabolism, gluconeogenesis, muscle differentiation, inflammation, circadian rhythm, PGC1a regulation, hypertension, and atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Nitric oxide coordinates metabolism, growth, and development via the nuclear receptor E75

Cáceres¹,

Necakov²,

Schwartz³

et al. 2011

Genes Dev.

124

173

View full text Add to dashboard Cite

Nitric oxide gas acts as a short-range signaling molecule in a vast array of important physiological processes, many of which include major changes in gene expression. How these genomic responses are induced, however, is poorly understood. Here, using genetic and chemical manipulations, we show that nitric oxide is produced in the Drosophila prothoracic gland, where it acts via the nuclear receptor ecdysone-induced protein 75 (E75), reversing its ability to interfere with its heterodimer partner, Drosophila hormone receptor 3 (DHR3). Manipulation of these interactions leads to gross alterations in feeding behavior, fat deposition, and developmental timing. These neuroendocrine interactions and consequences appear to be conserved in vertebrates.[Keywords: E75; DHR3; nitric oxide; Drosophila; metamorphosis; ecdysone; metabolism] Supplemental material is available for this article. In previous work, we showed that ecdysone-induced protein 75 (E75, also known as Eip75B; NR1D3) (Tweedie et al. 2009) contains heme constitutively bound to its ligand-binding domain (LBD), and that amino acids coordinately bound to the heme iron can be displaced in vitro by changes in redox state or the presence of nitric oxide (NO) gas (Pardee et al. 2004;Reinking et al. 2005;Marvin et al. 2009). In turn, these structural changes negate the ability of E75 to repress transcription and to reverse the positive transcriptional activity of its heterodimer partner, Drosophila hormone receptor 3 (DHR3; also known as DHR46, NR1F4) (Tweedie et al. 2009). Here, we look to see whether these interactions are relevant in vivo and, if so, what their roles are.One of the best-characterized roles of E75 and DHR3 in vivo is within the nuclear receptor (NR) transcriptional hierarchy that controls, and responds to, the production of the metamorphosis-inducing hormone ecdysone (diagrammed in Supplemental Fig. 1A). Upon binding ecdysone, the ecdysone receptor (EcR) acts as a heterodimer with a second NR, ultraspiracle (USP), to activate transcription of DHR3 and the E75 isoform E75A (Koelle et al. 1991;Lam et al. 1997Lam et al. , 1999White et al. 1997;Bialecki et al. 2002). DHR3 then promotes its own continued expression as well as that of the E75 splice variant E75B and the downstream NR gene bFtz-F1. bFTZ-F1, in turn, activates the expression of ecdysone synthetic enzyme genes (Lavorgna et al. 1993;Woodard et al. 1994;Broadus et al. 1999), resulting in another round of ecdysone production. The major site of larval ecdysone production is the prothoracic gland (PG) (diagrammed in Supplemental Fig. 1B). The PG is also a major site of NO synthase (Nos) expression (Wildemann and Bicker 1999). Hence, we looked to see whether E75 and NO are present and interactive in this tissue, with the hypothesis that activation of bFtz-F1 transcription by DHR3 requires inactivation of E75 isoforms by NO. As predicted, all of the above-listed genes are expressed in the PG toward the end of third instar development, and disruption of their expression or activity leads to molec...

show abstract

Section: Discussionmentioning

confidence: 99%

Nitric oxide coordinates metabolism, growth, and development via the nuclear receptor E75

Cáceres¹,

Necakov²,

Schwartz³

et al. 2011

Genes Dev.

124

173

View full text Add to dashboard Cite

show abstract

“…FMD is a marker of endothelial function, an early-stage abnormality in atherosclerosis, and is especially related to endothelial NO bioavailability, which in turn has pivotal roles in vascular and organ protection. 3,4) Thus, FMD may have the potential to predict subclinical vascular or organ damage in subjects with risk factors for cardiovascular disease, although this potential has not yet been fully clarified. In the present study, we hope to evaluate whether the addition of FMD and proteomic biomarkers to the conventional risk factors for cardiovascular risk assessment will improve the accuracy of outcome prediction in patients with CAD (study group A), and the rate of progression of carotid atherosclerosis, arterial stiffness or microalbuminuria in subjects with hypertension or diabetes mellitus (study group B).…”

Section: Discussionmentioning

confidence: 99%

“…1,2) The flow-mediated vasodilatation of the brachial artery (FMD) is known as a marker which is related to endothelial NO bioavailability. 3,4) Therefore, several studies have suggested the usefulness of FMD measurement in the risk Vol 53 No 3 ENDOTHELIAL FUNCTION AND PROGNOSIS stratification for cardiovascular disease in all stages on the cardiovascular disease continuum. 1,2,4,5) Study aims: The present multicenter prospective study has 1 primary objective: to establish the usefulness of FMD as measured by online semi-automatic software (usually a dedicated device for FMD measurement) in the risk stratification for cardiovascular diseases in Japanese subjects.…”

mentioning

confidence: 99%

“…3,4) Therefore, several studies have suggested the usefulness of FMD measurement in the risk Vol 53 No 3 ENDOTHELIAL FUNCTION AND PROGNOSIS stratification for cardiovascular disease in all stages on the cardiovascular disease continuum. 1,2,4,5) Study aims: The present multicenter prospective study has 1 primary objective: to establish the usefulness of FMD as measured by online semi-automatic software (usually a dedicated device for FMD measurement) in the risk stratification for cardiovascular diseases in Japanese subjects. In addition, there are 4 proposed secondary objectives, as follows: 1) to establish standardized FMD values and the annual rates of FMD change in healthy subjects, and also examine whether the development of the conventional risk factors for cardiovascular disease might modulate the annual rates of FMD change; 2) to assess the predictive value of FMD for future cardiovascular events in Japanese subjects with coronary artery disease (CAD), independent of the conventional risk factors for cardiovascular disease; 6) 3) to evaluate the usefulness of a multimarker strategy, including measurements of FMD, pulse-wave velocity (PWV), 7) ankle-brachial pressure index (ABI), biochemical markers (serum C-reactive protein [CRP], oxidized low-density lipoprotein cholesterol, and plasma B-type natriuretic peptide [BNP] levels) 8) and a proteomic biomarker 9) identified by mass-spectroscopic analysis, to assess the prognosis of Japanese subjects with CAD; and 4) to clarify whether FMD might serve as a reliable predictor of the rate of progression of carotid atherosclerosis, 10) arterial stiffness and microalbuminuria in subjects with hypertension or diabetes mellitus, independent of the biochemical and proteomic biomarkers.…”

mentioning

confidence: 99%

See 1 more Smart Citation

A Multicenter Study Design to Assess the Clinical Usefulness of Semi-Automatic Measurement of Flow-Mediated Vasodilatation of the Brachial Artery

et al. 2012

View full text Add to dashboard Cite

SummaryFlow-mediated vasodilatation of the brachial artery (FMD) is a marker which is related to endothelial nitric oxide bioavailability. Commercially available ultrasound machines equipped with online computer-assisted semi-automatic analysis software to measure FMD have recently become available in Japan. These devices enable more convenient examination, enhanced reproducibility of FMD measurement, and a shortened examination time. Using such devices, in the present multicenter prospective study we propose to: 1) establish standardized FMD values and determine the annual rates of FMD change in healthy subjects; 2) confirm the predictive value of FMD for future cardiovascular events in Japanese subjects; 3) evaluate the potential usefulness of a multimarker strategy, including measurements of FMD, pulsewave velocity (PWV), ankle-brachial pressure index, biochemical markers, and proteomic biomarkers obtained by mass spectroscopic analysis to assess the prognosis of subjects with coronary artery disease; and 4) clarify the usefulness of FMD measurement to predict the rate of progression of carotid atherosclerosis, arterial stiffness and microalbuminuria in subjects with hypertension or diabetes mellitus. In total, we estimate that approximately 4000 Japanese subjects in 3 different study groups will eventually be enrolled in this prospective observational investigation. We anticipate that the present study will provide important evidence for the usefulness of FMD measurement in the risk stratification for cardiovascular disease. (Int Heart J 2012; 53: 170-175)

show abstract

“…7 Walaupun demikian, hubungan NO dan gangguan fungsi ginjal pada pasien sepsis sampai saat ini masih kontroversi. Sebagian peneliti melaporkan terdapat hubungan antara NO dan fungsi ginjal, 810 tetapi peneliti lain melaporkan hal yang bertentangan.…”

unclassified

Hubungan Kadar Serum Metabolit Nitrit Oksida dan Gangguan Fungsi Ginjal pada Sepsis

Mandei

Chandra

Wilar

et al. 2016

View full text Add to dashboard Cite

S epsis adalah respons sistemik terhadap infeksi yang merupakan penyebab utama morbiditas dan mortalitas pada anak dengan perkiraan 42.000 kasus per tahun di Amerika Serikat dan rerata mortalitas 10%.13 Salah satu komplikasi sepsis yang paling serius adalah gangguan ginjal akut. Hal ini disebabkan karena gangguan ginjal akut berhubungan dengan keparahan sepsis dan peningkatan biaya rawatan rumah sakit. 4 Patofisiologi sepsis sampai saat ini masih belum diketahui dengan pasti.5 Teori yang banyak dianut sampai saat ini adalah respons inflamasi yang tidak terkontrol dengan kehilangan homeostasis normal antara respons inflamasi sistemik dan antiinflamasi. Kata kunci. Sepsis, nitrit oksida, kreatinin, fungsi ginjal.

show abstract

Bench-to-bedside review: Nitric oxide in critical illness – update 2008

Cited by 66 publications

References 57 publications

Nitric oxide coordinates metabolism, growth, and development via the nuclear receptor E75

Nitric oxide coordinates metabolism, growth, and development via the nuclear receptor E75

A Multicenter Study Design to Assess the Clinical Usefulness of Semi-Automatic Measurement of Flow-Mediated Vasodilatation of the Brachial Artery

Hubungan Kadar Serum Metabolit Nitrit Oksida dan Gangguan Fungsi Ginjal pada Sepsis

Contact Info

Product

Resources

About