Bench surgery with autotransplantation for bilateral Wilms tumor—A feasible technique for renal sinus invasion

Abstract

PurposeBilateral Wilms tumor (BWT) with renal sinus invasion requires extremely difficult surgical care. This study presents an alternative strategy for tumor removal while at the same time preserving the renal parenchyma.Materials and methodsIn total, 9 cases of synchronous BWT were admitted to our hospital between May 2016 to Aug 2020. We retrospectively reviewed the clinical data, surgical technique, and functional and oncological outcomes of these cases.ResultsThe 9 cases included 3 males and 6 females, with a median age of 12 months at surgery (range 7–40). A total of 14 kidney units had renal sinus invasion (77.8%), whereas multifocal neoplasms were observed in 7 units (38.9%). The local stage distribution revealed 1 kidney with stage I, 10 kidneys with stage II, and 7 kidneys with stage III. Nephron-sparing surgery was performed on 15 kidney units (83.3%), among which 13 (72.2%) underwent bench surgery with autotransplantation (BS-AT), whereas 2 (11.1%) were subjected to tumor enucleation in vivo. Urinary leakage was the most prevalent postoperative complication. We observed negative margins. During the mean follow-up of 28.4 months, 2 patients (22.2%) succumbed from sepsis and renal failure, respectively, whereas the other 7 (77.8%) survived without recurrence. Survivors experienced an estimated glomerular filtration rate of 81 ± 15.4 ml/(min × 1.73 m2). The endpoint renal volume of 9 renal units receiving BS-AT significantly increased (P = 0.02).ConclusionsIn summary, the surgical management of bilateral Wilms tumor requires meticulous operative approach and technique. Besides, BS-AT provides a viable alternative to nephron-sparing surgery for BWT patients with renal sinus invasion.

Is RENAL Nephrometry Scoring System Suitable for Application in Bilateral Wilms Tumor?

“…The present study indicates that tumors undergoing NSS ex vivo had a higher complexity compared with tumors undergoing NSS in vivo. Meanwhile, our previous study has found that NSS ex vivo was a feasible technique for BWT with renal sinus invasion [24]. Regardless of the surgical approaches, the surgical di culty remains the collecting system or sinus invasion.…”

Ex Vivo Partial Nephrectomy and Autotransplantation for Complex and Multifocal Renal Cell Carcinoma at a Single Institution: A Case Series

“…Renal autotransplantation is performed for complex renal vascular diseases (renal artery aneurysms), extensive ureteric injuries, and conventionally unresectable renal tumors [6,11,12]. Several studies have reported that ex vivo PN and autotransplantation for highly complex renal tumors in solitary or bilateral multifocal kidneys result in excellent tumor control and preservation of renal function [12][13][14][15].…”