Beitrag zur Frage einer gestörten Nierenfunktion bei exogen-alimentärer Fettsucht

Glomerular Sclerosis in Patients with Massive Obesity

“…Since glomerular filtration rate is proportional to body weight [4], a positive correlation between the amount of global glomerular sclerosis and body weight was sought in obese patients and in controls. In both groups, a leastsquares best fit line between body weight and the percent age o f globally sclerotic glomeruli showed a negative trend (fig.…”

“…Obesity is a condition in which increased filtration may lead to glomerular damage [3], It is well known that patients with massive obesity have markedly increased glomerular filtration rates [4,5], Furthermore, such pa tients generally maintain remarkably constant body weights [6], Therefore, patients with massive obesity are likely to expose their glomeruli to the effects o f hyperfil tration over many years. While the incidence o f glomeru lar disease in obesity is not known, proteinuria has been reported in up to 41 % o f obese patients [7], In addition, there are case reports o f the nephrotic syndrome occur ring in association with a glomerular lesion resembling focal sclerosis [8], Patients with massive obesity might therefore provide an opportunity to assess the relation ship between increased filtration and glomerular damage in man.…”