Beitrag über das Porphyrin in Blut und Galle

Studies of Coproporphyrin. Ii. An Investigation of the Contribution to the Urinary Coproporphyrin of Hemoglobin and of Bacterial Metabolism in the Intestinal Tract 12

“…In contrast to the results of previous studies (17,18), relatively little protoporphyrin was recovered from the culture of E. coli in a medium containing blood. The explanation may lie in the much larger amount of hemoglobin which was exposed to bacterial action in the previous studies; it is also possible that the longer period of culture in the present study resulted in degradation and disappearance of an undetermined fraction of the protoporphyrin.…”

“…Hill and Holden (17) showed, however, that pure cultures of E. coli liberated free protoporphyrin from hemoglobin; this was confirmed by van den Bergh and co-workers (18). No direct evidence has been described, however, for the intestinal formation of coproporphyrin III from hemoglobin, although the above-mentioned work of Jakob's suggested that this might take place.…”

Free Erythrocyte Protoporphyrin 1

“…Studies were not done to establish the identity of the porphyrin responsible for the red fluorescence yielded by these samples of plasma. Previous studies of plasma porphyrins would suggest coproporphyrin as the most likely possibility (13)(14)(15)(16)(17)(18).…”

“…In the procedure employed in this study the erythrocytes were not washed except in cases of porphyria, lead poisoning or jaundice. It was felt that the results of the experiments in which the effect of washing of the cells was studied and the study of the plasma fluorescence, as well as consideration of the previously reported studies of plasma fluorescence (13)(14)(15)(16)(17)(18), justified this omission.…”

Concerning the Naturally Occurring Porphyrins. Iv. The Urinary Porphyrin in Lead Poisoning as Contrasted With That Excreted Normally and in Other Diseases 1

“…The isolation of coproporphyrin I from the urine of a patient with cincophen cirrhosis of the liver, also from the feces in hemolytic jaundice and pernicious anemia, was reported. Of particular interest was the consideration of these findings with relation to the clinical and experimental observations of Van den Bergh and coworkers (4,5). These investigators pointed out that human erythrocytes regularly contain protoporphyrin which is increased in amount in the same individuals who exhibit increases of coproporphyrin in the urine.…”