Beilschglabrines A and B: Two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra

Salleh, Wan Mohd Nuzul Hakimi Wan; Ahmad, Farediah; Khong, Heng Yen; Zulkifli, Razauden Mohamed; Chen, Jih Jung; Nahar, Lutfun; Wansi, Jean Duplex; Sarker, Satyajit D.

doi:10.1016/j.phytol.2016.04.013

Cited by 17 publications

(10 citation statements)

References 19 publications

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“…The isolated terpenoids were also reported most of the Piper species. They were readily identified by comparison of physical and spectroscopic data and mass spectrometry data with values found in the literature (Salleh et al, 2016a;Salleh et al, 2016b).…”

Section: Resultsmentioning

confidence: 95%

Aporphine alkaloids from Piper erecticaule and acetylcholinesterase inhibitory activity

Salleh¹,

Abdullah²,

Hashim³

et al. 2019

Bol Latinoam Caribe Plant Med Aromat

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Chemical constituents and biological activities of the aerial parts of Piper erecticaule C.DC. have been studied for the first time. Fractionation and purification of the extracts afforded aristolactam AII (1), aristolactam BII (2), piperolactam A (3), piperolactam C (4), piperolactam D (5), together with terpenoids of β-sitosterol, β-sitostenone, taraxerol, and lupeol. The structures of these compounds were obtained by analysis of their spectroscopic data, as well as the comparison with that of reported data. Acetylcholinesterase inhibitory activity revealed that compounds 1 and 3 showed strong AChE inhibitory effects with the percentage inhibition of 75.8% and 74.8%, respectively.Resumen: Se estudiaron por primera vez los constituyentes químicos y actividad biológica de las partes aéreas de Piper erecticaule C.DC. El fraccionamiento y la purificación de los extractos proporcionaron aristolactama AII (1), aristolactama BII (2), piperolactama A (3), piperolactama C (4), piperolactama D (5), junto con terpenoides de β-sitosterol, β-sitostenona, taraxerol, y el lupeol. Las estructuras de estos compuestos se obtuvieron mediante el análisis de sus datos espectroscópicos, así como mediante la comparación con datos ya informados. La actividad inhibidora de la acetilcolinesterasa reveló que los compuestos 1 y 3 mostraron un potente efecto inhibidor de la AChE con un porcentaje de inhibición del 75.8% y 74.8%, respectivamente. Este artículo puede ser citado como / This article must be cited as: WMNHW Salleh, N Abdullah, NA Hashim, HY Khong, S Khamis. 2019 Aporphine alkaloids from Piper erecticaule and acetylcholinesterase inhibitory activity. Bol Latinoam Caribe Plant Med Aromat 18 (5): 527 -532.

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Section: Resultsmentioning

confidence: 95%

Aporphine alkaloids from Piper erecticaule and acetylcholinesterase inhibitory activity

Salleh¹,

Abdullah²,

Hashim³

et al. 2019

Bol Latinoam Caribe Plant Med Aromat

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“…The chemical structures are shown in Figure 1. In addition, lupeol (7) [9], lupenone (8) [10], β-sitosterol (1) [11], and β-sitostenone (2) [12] were also identified. All secondary metabolites were identified by analyzing their spectroscopic data and comparing them with the literature data.…”

Section: Resultsmentioning

confidence: 99%

“…AChE inhibition (I%) 5,7-Dimethoxyflavone (3) 47.5% 4,5,7-Trimethoxyflavone (4) 52.8% 3',4',5,7-Tetramethoxyflavone (5) 58.2% 5-Hydroxy-7-methoxyflavone (6) 25.5% 5-Hydroxy-4ʹ,7-dimethoxyflavone (9) 24.2% Galantamine b…”

Section: Samplesmentioning

confidence: 99%

Chemical constituents and acetylcholinesterase inhibitory activity of Piper abbreviatum Opiz

Salleh¹,

Nafiah²,

Khong³

et al. 2021

Bull. Chem. Soc. Eth.

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Plants of the genus Piper have long been used as medicinal herbs. The chemistry of Piper species has been widely investigated and phytochemical investigations conducted in all parts of the world have led to the isolation of a number of physiologically active compounds. Thus, this study was carried out to investigate the phytochemicals from Piper abbreviatum and their acetylcholinesterase inhibitory activity, which has not been previously investigated. Fractionation and purification of the aerial parts of P. abbreviatum led to the isolation and identification of five methoxylated flavonoids, namely 5,7-dimethoxyflavone, 4ʹ,5,7-trimethoxyflavone, 3',4',5,7-tetramethoxyflavone, 5-hydroxy-7-methoxyflavone, 5-hydroxy-4ʹ,7-dimethoxyflavone, together with lupeol, lupenone, β-sitosterol, and β-sitostenone. The structures of these compounds were obtained by analysis of their spectroscopic data, as well as the comparison with that of reported data. Acetylcholinesterase inhibitory activity revealed that all isolated flavones were found to inhibit AChE with percentage inhibition values ranged from 24.2 to 58.2%. This is the first report on the isolation of methoxylated flavonoid from P. abbreviatum. The high variants of flavonoid compounds from this species may be used as chemotaxonomic markers for this Piper species. KEY WORDS: Piperaceae, Piper, Piper abbreviatum, Flavonoid, Acetylcholinesterase Bull. Chem. Soc. Ethiop. 2020, 34(3), 625-632. DOI: https://dx.doi.org/10.4314/bcse.v34i3.17

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“…The genus produces several classes of compounds such as terpenoids, endiandric acid derivatives, essential oils, fatty acids, epoxyfuranoid lignans, flavonoids, and alkaloids. Some of these compounds are reported to exhibit antioxidant, antibacterial, antimalarial and antituberculosis activities (Chen et al, 2007;Lenta et al, 2009;Chouna et al, 2010;Salleh et al, 2015b;Salleh et al, 2016a;Salleh et al, 2016b;Salleh et al, 2016c;Salleh et al, 2016d). Previous studies on the compositions of the essential oils of Beilschmiedia species have been reported on B.…”

Section: Introductionmentioning

confidence: 99%

Multivariate statistical analysis of the essential oils of five Beilschmiediaspecies from Peninsular Malaysia

Salleh¹,

Shaharudin²

2021

BLACPMA

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Identification of the chemical compositionof essential oils is very important for ensuring the quality of finished herbal products. The objective of the study was to analyze the chemical components present in the essential oils of five Beilschmiediaspecies (i.e. B. kunstleri, B. maingayi, B. penangiana, B. madang, and B. glabra) by multivariate data analysis using principal component analysis (PCA) and hierarchical clustering analysis (HCA) methods. The essential oils were obtained by hydrodistillation and fully characterized by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). A total of 108 chemical components were successfully identified from the essential oils of five Beilschmiediaspecies. The essential oils were characterized by high proportions of β-caryophyllene (B.kunstleri), δ-cadinene (B. penangianaand B. madang), and β-eudesmol (B. maingayiand B. glabra). Principal component analysis (PCA) and hierarchical cluster analysis (HCA) revealed that chemical similarity was highest for all samples, except for B. madang. The multivariate data analysis may be used for the identification and characterization of essential oils from different Beilschmiediaspecies that are to be used as raw materials of traditional herbal products.

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Beilschglabrines A and B: Two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra

Cited by 17 publications

References 19 publications

Aporphine alkaloids from Piper erecticaule and acetylcholinesterase inhibitory activity

Aporphine alkaloids from Piper erecticaule and acetylcholinesterase inhibitory activity

Chemical constituents and acetylcholinesterase inhibitory activity of Piper abbreviatum Opiz

Multivariate statistical analysis of the essential oils of five Beilschmiediaspecies from Peninsular Malaysia

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