Beijing Aging Brain Rejuvenation Initiative: aging with grace

Chen, Yaojing; Xu, Kai; Yang, Caishui; Li, Xin; Li, He; Zhang, Junying; Wei, Dongfeng; Xia, Jianan; Wan, Tao; Lü, Peng; Wang, Jun; Shu, Ni; Peng, Dantao; Jia, Jianjun; Zhang, Wei; Cui, Ruixue; Wang, Yanping; Guan, Qing; Luo, Yuejia; Wang, Fang; Wang, QingShan; Chen, Ke-Wei; Wang, Xiaomin; Zhao, Jizong; Wang, Yongyan; Zhang, Zhanjun

doi:10.1360/n052018-00106

Cited by 12 publications

(5 citation statements)

References 32 publications

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“…All participants in this study were the same as those in our previous study (Sang et al, 2021), were from the Beijing Aging Rejuvenation Initiative (BABRI) study (Chen et al, 2018; Yang et al, 2021), an ongoing longitudinal study examining the brain and cognitive decline in community-dwelling elderly individuals. All participants in this study met the following criteria: (1) native Chinese-speaking individuals over 50 years of age without dementia who had normal daily living abilities; (2) no history of brain tumors, neurological or psychiatric disorders, or addiction; (3) no conditions known to affect cerebral function, including alcoholism, current depression, Parkinson’s disease, or epilepsy; and (4) no contraindications to magnetic resonance imaging (MRI).…”

Section: Methodsmentioning

confidence: 99%

Cerebral thickness reveals sex differences in verbal and visuospatial memory

Sang,

Zhao,

et al. 2023

Preprint

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Although sex differences in behavior/cognition and brain have previously been reported and reviewed, a sex difference of verbal and visuospatial memory and the underlying neural basis still need to be explored further. In this study, we used a machine learning model to explore a sex difference of the association between brain structure and verbal/visuospatial memory based on a community older cohort (n = 1153, age ranged from 50.42 to 86.67 years). We found females outperformed males in verbal memory (t= -5.431,p< 0.001), while males outperformed females in visuospatial memory (t= 3.201,p= 0.001). The key regions related to verbal memory in females include medial temporal cortex, orbitofrontal cortex, and some regions around insula. According to the overlapping with Yeo’s 7 networks, those regions are more located in limbic, dorsal attention and default model networks, and they are also associated with face recognition and perception processes. The key regions related to visuospatial memory, which is outstanding in males, include lateral prefrontal cortex, anterior cingulate gyrus, and some occipital regions. They overlapped more with dorsal attention, frontoparietal and visual networks, and associated with object recognition processes. These findings imply the memory performance advantage of females and males is related to the different memory preprocessing tendencies and its associated network.

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Section: Methodsmentioning

confidence: 99%

Cerebral thickness reveals sex differences in verbal and visuospatial memory

Sang,

Zhao,

et al. 2023

Preprint

Self Cite

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“…This study included 158 native Chinese participants, all from an ongoing longitudinal study that collected comprehensive brain imaging and neurocognitive test data in an elderly community-dwelling sample, the Beijing Aging Brain Rejuvenation Initiative (BABRI) [ 9 ], which comprises a large database of 9532 records. The participant inclusion criteria were as follows: (1) more than 6 years of education; (2) aged between 50 and 80 years old; (3) right-handed; (4) scored no less than 24 on the Mini-Mental Status Examination (MMSE), Chinese version; (5) no history of nephritis, coronary disease, gastrointestinal disease, tumors, psychiatric illness, or dementia; (6) no contraindications to MRI; (7) availability of complete neuropsychological tests for MCI assessment.…”

Section: Methodsmentioning

confidence: 99%

Divergent brain regional atrophy and associated fiber disruption in amnestic and non-amnestic MCI

Du,

Dang,

Chen

et al. 2023

Alz Res Therapy

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Background Understanding the pathological characteristics of various mild cognitive impairment (MCI) subtypes is crucial for the differential diagnosis of dementia. The purpose of this study was to feature divergent symptom-deficit profiles in amnestic MCI (aMCI) and non-amnestic MCI (naMCI). Methods T1 and DTI MRI data from a total of 158 older adults with 50 normal controls, 56 aMCI, and 52 naMCI were included. The voxel-wise gray matter volumes and the number of seed-based white matter fiber bundles were compared among these three groups. Furthermore, correlation and mediation analyses between the neuroimaging indices and cognitive measures were performed. Results The aMCI with specific memory abnormalities was characterized by volumetric atrophy of the left hippocampus but not by damage in the linked white matter fiber bundles. Conversely, naMCI was characterized by both the altered volume of the right inferior frontal gyrus and the significant damage to fiber bundles traversing the region in all three directions, not only affecting fibers around the atrophied area but also distant fibers. Mediation analyses of gray matter-white matter-cognition showed that gray matter atrophy affects the number of fiber bundles and further affects attention and executive function. Meanwhile, fiber bundle damage also affects gray matter volume, which further affects visual processing and language. Conclusions The divergent structural damage patterns of the MCI subtypes and cognitive dysfunctions highlight the importance of detailed differential diagnoses in the early stages of pathological neurodegenerative diseases to deepen the understanding of dementia subtypes and inform targeted early clinical interventions.

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“…The participants in the present study were recruited from the Beijing Aging Brain Rejuvenation Initiative (BABRI) project. BABRI is an ongoing community‐based cohort study in China, which focuses on the asymptomatic stages of dementia, aims to find markers for early detection of cognitive impairment, and serves for both scientific types of research and preventive clinical trials in the field of normal aging and dementia (Chen et al, 2018; Yang et al, 2021). All enrolled participants were Han Chinese, 83 patients with AD and 38 NC were included in the current study.…”

Section: Methodsmentioning

confidence: 99%

Tau as a biomarker of cognitive impairment and neuropsychiatric symptom in Alzheimer's disease

Dang

Qian

Zhao

et al. 2022

Human Brain Mapping

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The A/T/N research framework has been proposed for the diagnosis and prognosis of Alzheimer's disease (AD). However, the spatial distribution of ATN biomarkers and their relationship with cognitive impairment and neuropsychiatric symptoms (NPS) need further clarification in patients with AD. We scanned 83 AD patients and 38 cognitively normal controls who independently completed the mini‐mental state examination and Neuropsychiatric Inventory scales. Tau, Aβ, and hypometabolism spatial patterns were characterized using Statistical Parametric Mapping together with [18F]flortaucipir, [18F]florbetapir, and [18F]FDG positron emission tomography. Piecewise linear regression, two‐sample t ‐tests, and support vector machine algorithms were used to explore the relationship between tau, Aβ, and hypometabolism and cognition, NPS, and AD diagnosis. The results showed that regions with tau deposition are region‐specific and mainly occurred in inferior temporal lobes in AD, which extensively overlaps with the hypometabolic regions. While the deposition regions of Aβ were unique and the regions affected by hypometabolism were widely distributed. Unlike Aβ, tau and hypometabolism build up monotonically with increasing cognitive impairment in the late stages of AD. In addition, NPS in AD were associated with tau deposition closely, followed by hypometabolism, but not with Aβ. Finally, hypometabolism and tau had higher accuracy in differentiating the AD patients from controls (accuracy = 0.88, accuracy = 0.85) than Aβ (accuracy = 0.81), and the combined three were the highest (accuracy = 0.95). These findings suggest tau pathology is superior over Aβ and glucose metabolism to identify cognitive impairment and NPS. Its results support tau accumulation can be used as a biomarker of clinical impairment in AD.

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Beijing Aging Brain Rejuvenation Initiative: aging with grace

Cited by 12 publications

References 32 publications

Cerebral thickness reveals sex differences in verbal and visuospatial memory

Cerebral thickness reveals sex differences in verbal and visuospatial memory

Divergent brain regional atrophy and associated fiber disruption in amnestic and non-amnestic MCI

Tau as a biomarker of cognitive impairment and neuropsychiatric symptom in Alzheimer's disease

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