Behind The Eye

Jenssen, Toril

doi:10.4324/9781351217149

Cited by 2 publications

(2 citation statements)

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“…2. The anti HIV/ anti viral activity alongwith the antifungal activity of these peptides has been observed experimentally through cellular assays [31][32][33][34] but the mechanistic aspects still remain ambiguous at the molecular level. The PBS of ss viral RNA was taken from pdb file 4B3O corresponding to HIV-1RT ternary complex.…”

Section: Resultsmentioning

confidence: 99%

“…Also, when competing with primer for template show poor competitive inhibition. Compared to natural peptides which do show anti HIV activity [31][32][33][34] , designed compound 1 seems to be a good compromise between druggability and anti HIV activity. The encouraging aspect is that there is wide scope for development of a good, competitive peptidomimetic inhibitor of HIV-1RT.…”

Section: R a F Tmentioning

confidence: 99%

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A mechanistic study of anti-HIV activities of antifungal peptides

Omar

Yadav

2017

Can. J. Chem.

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HIV patients are constantly at risk of developing internal fungal infection and are thus regularly prescribed antifungal medications. Several classes of antifungal agents have been developed to combat ever increasing cases of resistant strains of fungi. Azoles, despite being the most popular clinical choice, are not devoid of side effects. Many antimicrobial peptides have also been tested in search of safe, nontoxic antifungals but none succeeded as a commercial alternative. Recent research attempts show continued interest in these compounds and the complexities associated. Some experimental observations indicate involvement of these antimicrobial peptides in enhancing the efficacy of anti-HIV agents. We present here an intertwined approach to deal with two fatal diseases, internal fungal infection and HIV infection. Several naturally occurring antimicrobial peptides have been studied for their possible interaction with the viral RNA primer binding site (template) through interactions other than the base pair – base pair type. Peptides have been prepared and docked into viral template utilizing extra precision, flexible ligand docking. Implicit solvent was added around the complex and MMGBSA interaction energies were computed. Druggability aspects were explored by calculating ADME-related properties. A peptidomimetic compound has been strategically designed to introduce some druggability features in the peptide maintaining its viral template inhibition capability. The designed peptidomimetic lead compound may help in obtaining nontoxic anti-HIV agents in the future. This is the first study to suggest a plausible explanation for the anti-HIV activity of antifungal peptides at the molecular level and corroborate experimental findings of synergistic effects of these peptides on anti-HIV agents.

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Section: Resultsmentioning

confidence: 99%

Section: R a F Tmentioning

confidence: 99%