Behçet's disease with multiple splenic abscesses in a child

Lim, Kyung In; Yang, Donghwa; Ryoo, Eell

doi:10.5217/ir.2017.15.3.422

Cited by 6 publications

(2 citation statements)

References 14 publications

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“…An aseptic abscess (AA) is an autoinflammatory disorder characterized by necrotic lymph nodes and an abscess involving internal organs, most commonly the spleen associated with negative cultures and serologic tests, failure of antibiotic therapy, and improvement on corticosteroids [ 4 , 5 ]. Aseptic splenic abscesses associated with BD are rarely described in the literature [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Aseptic Abscess of the Spleen as an Antecedent Manifestation of Behçet’s Disease

Jazeer¹,

Antony²,

Pakkiyaretnam³

2023

Cureus

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Behçet’s disease (BD) is a multisystem autoimmune vasculitis that manifests as oral and genital ulcers with varying degrees of dermatological and ocular involvement. Aseptic splenic abscesses are a rare entity commonly occurring in autoinflammatory diseases and are rarely associated with BD. Here, we present the case of a 16-year-old male with BD who presented with prolonged fever and constitutional symptoms and was found to have an aseptic splenic abscess. Rapid resolution of the symptoms along with radiological evidence of abscess shrinkage was achieved with corticosteroid therapy.

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Section: Introductionmentioning

confidence: 99%

Aseptic Abscess of the Spleen as an Antecedent Manifestation of Behçet’s Disease

Jazeer¹,

Antony²,

Pakkiyaretnam³

2023

Cureus

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“…Although the spleen is the dominant organ involved, aseptic abscesses can also affect the abdominal lymph nodes, liver, lung, pancreas, and brain ( 4 ). Aseptic splenic abscesses are most frequently reported in autoimmune and autoinflammatory conditions such as Crohn's disease, neutrophilic dermatosis, relapsing polychondritis, and Behcet's disease ( 4 , 5 ). These abscesses, however, are not a recognized manifestation of SLE.…”

Section: Introductionmentioning

confidence: 99%

Case report: Aseptic splenic abscesses in childhood-onset systemic lupus erythematosus

et al. 2023

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BackgroundSystemic lupus erythematosus (SLE) can involve any organ system and cause a wide range of manifestations. Noninfectious inflammatory lesions termed aseptic abscesses have been reported in some autoimmune and autoinflammatory conditions but not in childhood-onset SLE. In this report, we highlight the unusual finding of occult splenic abscesses in two children diagnosed with SLE who had no evidence of concomitant infection.Case presentationAn 8-year-old and an 11-year-old were admitted separately to the hospital with fever for 7 and 14 days, respectively. In the younger child, a generalized rash preceded the fever. Both had been well, with no significant past medical history prior to the onset of the illness. In both girls, abdominal ultrasonography showed multiple small hypoechoic lesions suggestive of abscesses scattered throughout the spleen. Their C-reactive protein and blood cultures were negative, and symptoms persisted despite intravenous antibiotics. Fulfilling the clinical and immunologic criteria for diagnosis, both were ultimately diagnosed with childhood-onset SLE. Rapid recovery of symptoms and complete resolution of the abscesses ensued with corticosteroids and immunosuppressive therapy.ConclusionsThese two cases suggest that aseptic splenic abscesses may occur in childhood-onset SLE. Autoimmune conditions such as SLE should be included in the differential diagnosis of children with occult splenic abscesses.

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