Behçet's disease involving the breast

Soleto, María Jesús; Marcos, Lourdes

doi:10.1007/s00330-002-1420-4

Cited by 8 publications

(2 citation statements)

References 7 publications

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“…[2] GCA, GPA, and PAN are the most frequently reported types of vasculitis involving the breast, [ 2 , 10 ] with microscopic polyangiitis [11] and Behcet's vasculitis also having been reported. [ 12 , 13 ] In our case, the patient did not present with definite symptoms, other than fever and fatigue. Moreover, the lesion in the left breast could not be identified by careful and thorough physical examination or general imaging alone.…”

Section: Discussionmentioning

confidence: 53%

18F-Fluorodeoxyglucose positron emission tomography computed tomography detection of single organ vasculitis of the breast

Harada

Sasaki

Tokunaga³

et al. 2021

Medicine

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Rationale: Although single organ vasculitis (SOV) is a rare occurrence and it is difficult to diagnose, its possibility as a cause of fever of unknown origin (FUO) must be considered. Recently, the usefulness of 18F-fluorodeoxyglucose positron emission tomography computed tomography (FDG PET/CT) in the diagnosis of unknown fevers due to vasculitis, especially in cases of small and medium-sized vasculitis, has begun to be pointed out. Patient concerns: We report the case of an 84-year-old woman with persisting fever for more than 2 weeks. She had no accompanying symptoms, other than fever, and the physical examination, echocardiography, and contrast-enhanced CT did not reveal any diagnostic clue. Diagnoses: The FDG PET/CT revealed positive uptakes of FDG in the left breast, with a standardized uptake value (SUV) of 2.9. The biopsy specimen of the left breast lesion revealed rupture of the elastic plate and evidence of fibrinoid necrosis of arteries, leading to the diagnosis of polyarteritis (PAN). Further angiographic examination and additional imaging did not reveal the presence of other lesions. Therefore, the diagnosis was established as a PAN-SOV of the left breast. Interventions: This patient has improved with follow-up only. Outcomes: There has been no evidence of a relapse of PAN over a 5-year follow-up period. Lessons: SOV presenting with unspecific local symptoms is difficult to diagnose based on the medical history and clinical examination. Our findings show that early “Combination of PET-CT and biopsy” can be a powerful diagnostic tool in patients with FUO for whom diagnosis of the underlying cause is difficult despite appropriate clinical examination.

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Section: Discussionmentioning

confidence: 53%

18F-Fluorodeoxyglucose positron emission tomography computed tomography detection of single organ vasculitis of the breast

Harada

Sasaki

Tokunaga³

et al. 2021

Medicine

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“…Behçet's disease targeting the breast is very rare. Three cases have been reported, presenting as inflammatory breast tenderness or ulcers [174][175][176]. One other case of Behçet's disease involving the breast was reported in a male patient with ductal ectasia rather than vasculitis ( §4) [69].…”

Section: Behçet's Diseasementioning

confidence: 99%

Mastitis in Autoimmune Diseases: Review of the Literature, Diagnostic Pathway, and Pathophysiological Key Players

Goulabchand

Hafidi

Perre

et al. 2020

JCM

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Mastitis frequently affects women of childbearing age. Of all the pathological breast conditions requiring specific management, autoimmune mastitis is in the third position after infection and breast cancer. The aim of this literature review was to make a comprehensive description of autoimmune diseases targeting the mammary gland. Four main histological patterns of autoimmune mastitis are described: (i) lymphocytic infiltrates; (ii) ductal ectasia; (iii) granulomatous mastitis; and (iv) vasculitis. Our literature search found that all types of autoimmune disease may target the mammary gland: organ-specific diseases (diabetes, thyroiditis); connective tissue diseases (such as systemic erythematosus lupus or Sjögren’s syndrome); vasculitides (granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, giant cell arteritis, polyarteritis nodosa, Behçet’s disease); granulomatous diseases (sarcoidosis, Crohn’s disease); and IgG4-related disease. Cases of breast-specific autoimmune diseases have also been reported, including idiopathic granulomatous mastitis. These breast-limited inflammatory diseases are sometimes the first symptom of a systemic autoimmune disease. Although autoimmune mastitis is rare, it is probably underdiagnosed or misdiagnosed. Early diagnosis may allow us to detect systemic diseases at an earlier stage, which could help to initiate a prompt, appropriate therapeutic strategy. In case of suspected autoimmune mastitis, we hereby propose a diagnostic pathway and discuss the potential pathophysiological pathways leading to autoimmune breast damage.

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Systemic vasculitis involving the breast: a case report and literature review

Ren

Liu

et al. 2019

Rheumatol Int

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Behçet's disease involving the breast

Cited by 8 publications

References 7 publications

18F-Fluorodeoxyglucose positron emission tomography computed tomography detection of single organ vasculitis of the breast

18F-Fluorodeoxyglucose positron emission tomography computed tomography detection of single organ vasculitis of the breast

Mastitis in Autoimmune Diseases: Review of the Literature, Diagnostic Pathway, and Pathophysiological Key Players

Systemic vasculitis involving the breast: a case report and literature review

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