Behcet’s disease in Iran: analysis of 6500 cases

Davatchi, Fereydoun; Shahram, Farhad; Chams‐Davatchi, Cheyda; Shams, Hormoz; Nadji, Abdolhadi; Akhlaghi, Maassoumeh; Faezi, Tahereh; Ghodsi, Zahra; Larimi, Roghieh; Ashofteh, Farima; Abdollahi, Bahar Sadeghi

doi:10.1111/j.1756-185x.2010.01549.x

Cited by 161 publications

(124 citation statements)

References 20 publications

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“…Of 6500 Iranian patients with BD, 1.1% had vena cava thrombosis. 58 The rate of venous involvement varies between 4% and 38%. 59 Certain combinations of symptoms occur more frequently than others in patients with BD.…”

Section: Behçet's Diseasementioning

confidence: 99%

Venous thromboembolism in systemic autoimmune diseases: A narrative review with emphasis on primary systemic vasculitides

Tamaki

Khasnis

2015

Vasc Med

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Venous thromboembolism (VTE) is a prevalent multifactorial health condition associated with significant morbidity and mortality. Population-based epidemiological studies have revealed an association between systemic autoimmune diseases and deep venous thrombosis (DVT)/VTE. The etiopathogenesis of increased risk of VTE in systemic autoimmune diseases is not entirely clear but multiple contributors have been explored, especially in the context of systemic inflammation and disordered thrombogenesis. Epidemiologic data on increased risk of VTE in patients with primary systemic vasculitides (PSV) have accumulated in recent years and some of these studies suggest the increased risk while patients have active diseases. This could lead us to hypothesize that venous vascular inflammation has a role to play in this phenomenon, but this is unproven. The role of immunosuppressive agents in modulating the risk of VTE in patients with PSV is not yet clear except for Behçet's disease, where most of the studies are retrospective. Sensitizing physicians to this complication has implications for prevention and optimal management of patients with these complex diseases. This review will focus on the epidemiology and available evidence regarding pathogenesis, and will attempt to summarize the best available data regarding evaluation and treatment of these patients.

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Section: Behçet's Diseasementioning

confidence: 99%

Venous thromboembolism in systemic autoimmune diseases: A narrative review with emphasis on primary systemic vasculitides

Tamaki

Khasnis

2015

Vasc Med

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“…Davatchi had summarized 6500 cases in Iran, the frequency of aneurysm was 0.5%. 1) Saadoun showed that the main cause of death in BD patients was major vessel disease, mainly arterial aneurysm and Budd-Chiari syndrome, about 43.9% 4) Medicine and surgery therapy would be better to controlling the symptom.…”

Section: Discussionmentioning

confidence: 99%

“…The frequency of vascular involvement is about 8%, 1) among which aneurysm is rare. We described a male with a five years history of BD, who developed an ascending aortic aneurysm.…”

Section: Introductionmentioning

confidence: 99%

Recurrent Aortic Aneurysm due to Behcet^|^#8217;s Disease: A Case Report from China

Zhang

Jian

Liu

et al. 2013

ATCS

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In this report, we present a twenty-nine year old patient with a five-year history of Behcet's disease (BD), who developed an ascending aortic aneurysm. Chest enhanced computed tomography scanning demonstrated a saccular aneurysm of the ascending aorta, with a maximum diameter of 11 cm. The patient was administered with prednisone、thalidomide and anticoagulant. A regular follow up was carried out. The patient lived well with blood sedimentation and C-reactive protein in the normal range.Keywords: Behcet's disease, ascending aortic aneurysm, thalidomide, anticoagulation prosthetic graft was utilized. No pathological examination was performed. Cervical vascular murmur disappeared after the surgery. Three years later，before admission to our department, he was worried about recurrent oral and genital ulcers. Physical examination showed multiple ulcers on mouth mucosa and skin of scrotum and swelling in the superior extremity of the chest; the diameter of the basilar part was about 5 cm, and the cutaneous pathergy test was positive. Blood examination showed a white blood cell count, red blood cell count, and hemoglobin, all in the normal range; blood sedimentation was 35 mm per hour, and C-reactive protein was 208 mg per liter. The blood culture was negative. Chest enhanced computed tomography scanning demonstrated that the patient has a saccular aneurysm on the ascending aorta with a diameter of 6 × 9 × 11 cm. The aneurysm showed a big cavity, combined with thrombosis (Figs. 2 and 3).The diagnosis relied upon the criteria proposed by the International Study Group for Behcet's disease. Because of poor economical conditions, the patient refused a second operation and accepted medicinal therapy. Medicinal therapy included oral prednisone 30 mg once per day, thalidomide 100 mg once per night, aspirin 100 mg once per day, aceclofenac 50 mg twice per day. Prednisone was decrement gradually to 10 mg per day as the mucosa ulcer improved. A regular follow-up was carried out strictly for eighteen months. The patient is asymptomatic and lives well now. He comes to our outpatient room, once a month.

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“…In a study from Japan, the mean age of onset was found 36.8 [24]. The mean age of onset of BD in many countries was shown in Table 2 [5,13,15,[23][24][25][26][27][28][29][30][31][32][33][34].…”

Section: Age and Gendermentioning

confidence: 99%

The Epidemiology of Behçet’s Disease

Oğuz¹,

Hizli²,

Gönül³

2017

Behcet's Disease

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Behçet's disease (BD), a chronic vasculitis afecting any type of the blood vessels, was irst described by a Turkish dermatologist Hulusi Behçet. Although it has a worldwide distribution, it is commonly seen in the Silk Road countries around the Mediterranean Sea. The country in which the disease is most commonly seen is Turkey with a prevalence of 20-602/100,000. The disease most appears between the second and fourth decades of the life. BD afects both genders equally. However, the gender distribution may difer among diferent regions.

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Behcet’s disease in Iran: analysis of 6500 cases

Abstract: Behcet's disease is mainly seen in young people. The most frequent symptoms are mucocutaneous, ocular and joint manifestations. Comparison with large series did not show major differences.

Cited by 161 publications

References 20 publications

Venous thromboembolism in systemic autoimmune diseases: A narrative review with emphasis on primary systemic vasculitides

Venous thromboembolism in systemic autoimmune diseases: A narrative review with emphasis on primary systemic vasculitides

Recurrent Aortic Aneurysm due to Behcet^|^#8217;s Disease: A Case Report from China

The Epidemiology of Behçet’s Disease

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