Behcet's disease: Diagnosed as isolated recurrent oral aphthae; a case report

Kudsy, Mayson; Khalayli, Naram; Allahham, Amr

doi:10.1016/j.amsu.2022.104327

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…Behçet's disease is most prevalent in the Silk Road countries, males, and typically presents in the third to fourth decade of life with specific diagnostic criteria [1,4] . Our patient is 32 years old Syrian male.…”

Section: Discussionmentioning

confidence: 99%

“…Behçet's disease is an inflammatory systemic vasculitis with unknown etiology, most prevalent in males in the Silk Road countries, and typically presents in the third to fourth decade of life [1] . It is characterized by oral and genital ulcerations, ocular manifestations, especially chronic relapsing uveitis, and systemic vasculitis involving arteries and veins of all sizes [2] .…”

Section: Introductionmentioning

confidence: 99%

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Undiagnosed Behçet’s disease presenting as Fournier’s gangrene in undiagnosed Behçet’s disease: a case report of a young adult male

Hodaifa,

Tarcha,

Alghawe

et al. 2024

International Journal of Surgery: Global Health

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Introduction and importance: Behçet’s disease is a rare systemic condition, with the mean age of patients being ~30 years. It affects men more than women. Behçet’s disease should be considered in any patient with a systemic inflammatory disease characterized by recurrent orogenital ulcers and uveitis. Fournier’s gangrene is a rare life-threatening bacterial genital infection that acquires at any age with male predominance. Case presentation: A healthy 32-year-old male presented with fatigue, fever, oral ulcers, and discrete scrotal ulcers. He had Fournier’s gangrene and a new diagnosis of Behçet’s disease. He was treated with intravenous antibiotics with surgical debridement. Before discharge, the patient was commenced on 1 mg/day of colchicine. During the follow-up visits, we noted small ulcerations without necrosis on the scrotum, which we started with oral prednisolone and oral methotrexate. He remains under their care 6 months later. Clinical discussion: The patient had recurrent oral ulcerations followed by genital aphthous ulceration and acneiform eruptions that met Behçet’s diagnosing criteria. Fournier’s gangrene on the scrotum was diagnosed due to the physical examination, radiological findings, and histological findings. A PubMed search reveals one similar case report. This patient’s only risk factor for Bechet’s was his ethnicity and male gender for Fournier’s gangrene. Conclusion: The young adult patient presented unusually, with a diagnosis of Fournier’s gangrene superimposed on undiagnosed Behçet’s disease. An understanding of the epidemiology and risk factors can help in the diagnosis of these rare pathologies.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Undiagnosed Behçet’s disease presenting as Fournier’s gangrene in undiagnosed Behçet’s disease: a case report of a young adult male

Hodaifa,

Tarcha,

Alghawe

et al. 2024

International Journal of Surgery: Global Health

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“…Bechet’s disease (BD) was first described by Hulusi Behcet in 1937, who identified the trial of symptoms: oral ulcers, genital ulcers, and uveitis 1 . BD tends to affect younger ages between 20 and 40 years of age and less frequently in children 2 , with a significant prevalence among the people from the Mediterranean, Middle East and Far East.…”

Section: Introductionmentioning

confidence: 99%

Prevalence, types, and characteristics of headache in Behcets disease without involvement of the central nervous system in the Syrian population: a case-cohort study

Rabah,

Deeb

et al. 2024

Annals of Medicine &Amp; Surgery

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Introduction: Oral ulcers, genital ulcers, and uveitis represent the typical trial of Behcet’s disease (BD). It is well common on the Old Silk Road. The mucocutaneous lesions are the hallmark of BD, but neurological involvement is one of the severe symptoms. Headaches may be an early sign of BD neurological involvement. This study aims to investigate the headache prevalence and its types, and characteristics in a Syrian sample of BD patients. Methods: BD patients were clinically interviewed and examined to collect their information, symptoms, and signs. the International Study Group for Behcet’s Disease diagnosis criteria was used to confirm the BD diagnosis. The International Classification of headaches was used when classifying the headaches. Results: 120 participants were included in the study. half of them were BD patients and the control group was also 60 participants. Among Syrian BD patients, 36.7% suffer from primary headaches and 36.7% suffer from secondary headaches. These findings were not significantly different between the BD patients and the healthy population. Our results showed that there was no statistically significant difference between the two groups. Conclusion: Headache should not be considered a predictor for neurological involvement among BD patients. Additional attention to BD patients or the specific treatment for headaches is not required and does not differ from the general population.

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New Medical Approaches in Crohn’s Disease Treatment

Miron¹

2023

AnnalsARSciMed

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Crohn's disease is a lifelong, relapsing systemic inflammatory disease of unknown etiology, mainly caused by an impaired immune response, characterized by chronic inflammation of any part of the gastrointestinal tract, with an increasing incidence worldwide. This disease is associated with multiple extraintestinal manifestations and patients frequently present persistent diarrhea, abdominal pain and weight loss. It affects people of all ages, but its onset generally occurs at a young age. Several triggers have been implicated in the etiopathology of Crohn's disease, including a dysregulated immune system, an altered intestinal microbiome, genetic susceptibility and environmental factors, but the main cause of the disease still remains an enigma. Due to its debut at a young age, in most cases, a long-term and early established treatment is undoubtedly required to prevent its progression with multiple intestinal and extraintestinal complications. Nowadays, novel biologic therapies or small-molecule drugs may deeply change the innate history of this pathology and could also decrease the rate of complications and the need for surgery. In order to establish the proper diagnosis, endoscopy with the histological evaluation of biopsy specimens represents the most reliable method, even if less invasive biomarkers are being developed. Crohn's disease is a comprehensive disease and the treatment should be adapted to each patient’s underlying pathogenetic mechanism.

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Behcet's disease: Diagnosed as isolated recurrent oral aphthae; a case report

Cited by 3 publications

References 18 publications

Undiagnosed Behçet’s disease presenting as Fournier’s gangrene in undiagnosed Behçet’s disease: a case report of a young adult male

Undiagnosed Behçet’s disease presenting as Fournier’s gangrene in undiagnosed Behçet’s disease: a case report of a young adult male

Prevalence, types, and characteristics of headache in Behcets disease without involvement of the central nervous system in the Syrian population: a case-cohort study

New Medical Approaches in Crohn’s Disease Treatment

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