Behcet disease: an undifferentiating and complex vasculitis

Pak, Daniel; Park, Hyon Ju

doi:10.1080/00325481.2022.2159205

Cited by 8 publications

(6 citation statements)

References 151 publications

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“…Avoiding triggers, whenever known, can also help prevent flare-ups. Regular dental hygiene can help avoid oral ulcers, and protection from sun and heat might help prevent skin lesions [75,76]. Regular followup with healthcare providers ensures appropriate management and prompt treatment of flare-ups [77][78][79][80].…”

Section: What Lifestyle Modifications Can Help Manage Behçet's Disease?mentioning

confidence: 99%

Behçet’s Disease, Pathogenesis, Clinical Features, and Treatment Approaches: A Comprehensive Review

Lavalle,

Caruso,

Foti

et al. 2024

Medicina

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Behçet’s disease is a systemic inflammatory disorder of unknown etiology. The disease manifests with diverse clinical symptoms, most commonly recurrent oral and genital ulcers, skin lesions, and uveitis, though it can affect multiple organ systems. Diagnosis is primarily clinical due to the lack of a definitive diagnostic test, and management involves a multidisciplinary approach to control inflammation and manage symptoms. Current treatment strategies involve corticosteroids, immunosuppressive agents, and, increasingly, biological therapies. Behçet’s disease exhibits a higher prevalence along the Silk Road, suggesting a role of environmental and genetic factors. Despite significant progress in understanding its clinical characteristics and treatment approaches, gaps remain in our understanding of its pathogenesis. Future research is needed to elucidate the disease’s pathophysiology and optimize treatment strategies.

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Section: What Lifestyle Modifications Can Help Manage Behçet's Disease?mentioning

confidence: 99%

Behçet’s Disease, Pathogenesis, Clinical Features, and Treatment Approaches: A Comprehensive Review

Lavalle,

Caruso,

Foti

et al. 2024

Medicina

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“…4 Notably, Behçet disease was not included in the analysis, likely because it is not commonly seen in the United Kingdom, with a prevalence estimated at 14.6 per 100,000 people compared with 420 per 100,000 people in Turkey. 5 The prevalence of neurologic manifestations in each of these disease conditions also varies widely in the literature. For example, neuropsychiatric symptoms in SLE have been estimated to occur in 12% to 95% of patients, 6 whereas neurologic involvement has been reported in 5% to 10% of patients with Behçet disease.…”

Section: Epidemiologymentioning

confidence: 99%

“…For example, neuropsychiatric symptoms in SLE have been estimated to occur in 12% to 95% of patients, 6 whereas neurologic involvement has been reported in 5% to 10% of patients with Behçet disease. 5 Regardless, it is important to recognize that neurologic involvement is reported in association with many, if not most, rheumatologic diseases, and there are clinical syndromes that are more commonly seen in association with each. TABLE 9-1 [7][8][9][10][11][12][13] outlines an overview of the more common neurologic manifestations of select rheumatologic diseases.…”

Section: Epidemiologymentioning

confidence: 99%

“…Of the rheumatologic diseases included, polymyalgia rheumatica had the highest incidence initially but has been surpassed by RA with an incidence of 94 per 100,000 person-years 4 . Notably, Behçet disease was not included in the analysis, likely because it is not commonly seen in the United Kingdom, with a prevalence estimated at 14.6 per 100,000 people compared with 420 per 100,000 people in Turkey 5 …”

Section: Epidemiologymentioning

confidence: 99%

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Neurologic Manifestations of Rheumatologic Disorders

McCombe

2024

CONTINUUM: Lifelong Learning in Neurology

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OBJECTIVE This article provides an overview of the neurologic manifestations of sarcoidosis and select rheumatologic disorders. An approach to the assessment and differential diagnosis of characteristic clinical presentations, including meningitis and vasculitis, is also reviewed. A review of treatment options is included as well as discussion of distinct areas of overlap, including rheumatologic disease in the setting of neuromyelitis spectrum disorder and demyelinating disease in the setting of tumor necrosis factor-α inhibitors. LATEST DEVELOPMENTS An increased understanding of the immune mechanisms involved in sarcoidosis and rheumatologic diseases has resulted in a greater diversity of therapeutic options for their treatment. Evidence directing the treatment of the central nervous system (CNS) manifestations of these same diseases is lacking, with a paucity of controlled trials. ESSENTIAL POINTS It is important to have a basic knowledge of the common CNS manifestations of rheumatologic diseases and sarcoidosis so that they can be recognized when encountered. In the context of many systemic inflammatory diseases, including systemic lupus erythematosus, IgG4-related disease, and sarcoidosis, CNS disease may be a presenting feature or occur without systemic manifestations of the disease, making familiarity with these diseases even more important.

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“…Described by Turkish dermatologist Hulusi Behçet in 1937 [1], Behçet's disease is a chronic vascular disorder responsible for the inflammation of multiple vital organs with triad of symptoms involving mouth and genital ulcers as well as recurrent ocular inflammation, which might be acute or relapsing [2 ▪ ].…”

Section: Introductionmentioning

confidence: 99%

Novel approach to Behçet's disease in the era of biologic agents

Khieu,

Chanthan

2023

Current Opinion in Ophthalmology

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Purpose This review aims to provide better understanding of modern modalities to investigate ocular symptoms of Behçet's disease in order to achieve appropriate management protocols and reduce irreversible visual loss. Relevant findings Current methods of diagnosing intraocular involvement in Behçet's disease gives clue to early diagnosis. In addition to standard ocular examination and fluorescein angiography, new noninvasive methods include ocular coherence tomography (OCT) and OCT angiography provide early detection of macular and retinal involvement that can be treated early to improve the prognosis. Summary Over the last decade, new multimodal imagings are becoming more accessible; therefore, rapid diagnosis can be made. In addition to newer approved biologic agents, ocular Behçet's disease is seen to be in better controlled with fewer complications.

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Behcet disease: an undifferentiating and complex vasculitis

Cited by 8 publications

References 151 publications

Behçet’s Disease, Pathogenesis, Clinical Features, and Treatment Approaches: A Comprehensive Review

Behçet’s Disease, Pathogenesis, Clinical Features, and Treatment Approaches: A Comprehensive Review

Neurologic Manifestations of Rheumatologic Disorders

Novel approach to Behçet's disease in the era of biologic agents

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