Behavioural-variant frontotemporal dementia: diagnosis, clinical staging, and management

Piguet, Olivier; Hornberger, Michael; Mioshi, Eneida; Hodges, John R.

doi:10.1016/s1474-4422(10)70299-4

Cited by 440 publications

(388 citation statements)

References 125 publications

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“…In particular, findings in behavioral variant of frontotemporal dementia (bvFTD), which shows severe loss of empathy even recognized in the diagnostic criteria (Piguet et al , 2011, Rascovsky et al , 2011, report that loss of empathy is more attributed to atrophy in the ventral medial prefrontal cortex (vMPFC), including anterior cingulate regions and not the MNS system per se (Shamay-Tsoory et al , 2004, Lough et al , 2006. Interestingly, similar vMPFC atrophy in bvFTD has been attributed to emotional blunting (Berenbaum et al , 1987, Rosen et al , 2002 and loss of insight (Hornberger et al , 2014), highlighting the critical function of this region in affective perspective-taking (i.e.…”

Section: A Role In Empathymentioning

confidence: 99%

Does dysfunction of the mirror neuron system contribute to symptoms in amyotrophic lateral sclerosis?

Eisen

Lemon

Kiernan

et al. 2015

Clinical Neurophysiology

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Eisen et al, Mirror Neurons in ALS 2 Declaration of interest:The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper. Eisen et al, Mirror Neurons in ALS 3 Abbreviations:ALS: Amyotrophic lateral sclerosis; ADM: adductor digiti minimi; APB: abductor pollicic brevis; bvFTD: Behavioral variant of frontotemporal dementia; FTD: Frontotemporal dementia; fMRI: functional MRI; MNS: Mirror neuron system; M1: Primary motor cortex; PTNs: Pyramidal tract neurons; vMPFC: Ventral medial prefrontal cortex. Eisen et al, Mirror Neurons in ALS 4 AbstractThere is growing evidence that mirror neurons, initially discovered over two decades ago in the monkey, are present in the human brain. In the monkey, mirror neurons characteristically fire not only when it is performing an action, such as grasping an object, but also when observing a similar action performed by another agent (human or monkey). In this review we discuss the origin, cortical distribution and possible functions of mirror neurons as a background to exploring their potential relevance in amyotrophic lateral sclerosis (ALS). We have recently proposed that ALS (and the related condition of frontotemporal dementia) may be viewed as a failure of interlinked functional complexes having their origins in key evolutionary adaptations. The mirror neuron system is considered by many to be the basis of primates' social cognition, with a clear evolutionary advantage. Impaired empathy and motor control has been related to a defective mirror neuron system. In ALS, the mirror neuron system might be implicated in empathy, the split-hand syndrome, gait, speech, and related languagegesture impairments.Eisen et al, Mirror Neurons in ALS 5

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Section: A Role In Empathymentioning

confidence: 99%

Does dysfunction of the mirror neuron system contribute to symptoms in amyotrophic lateral sclerosis?

Eisen

Lemon

Kiernan

et al. 2015

Clinical Neurophysiology

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“…Presenting features are insidious and include progressive changes in the patient's personality, interpersonal conduct, and emotional modulation (Gustafson 1987;Neary et al 1988;Piguet et al 2011a). A variable degree of language impairment is also present.…”

Section: The Concept Of Frontotemporal Dementia: Historical Overviewmentioning

confidence: 99%

“…2). They include most cases of PNFA, 45% of cases of bvFTD and some cases of SD (Piguet et al 2011a). Most cases of LPA are characterized by focal Alzheimer disease pathology (Ab plaques and tau tangles), as are some cases of SD and PNFA (Mesulam et al 2008;Rabinovici et al 2008).…”

Section: Histopathology Of Frontotemporal Lobar Degeneration (Ftld) Fmentioning

confidence: 99%

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Frontotemporal Dementia: Implications for Understanding Alzheimer Disease

Goedert¹,

Ghetti²,

Spillantini³

2011

Cold Spring Harbor Perspectives in Medicine

137

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“…Los pacientes con DFTvc frecuentemente son mal diagnosticados como portadores de trastornos psiquiátricos u otras enfermedades neurológicas, porque su presentación involucra cambios conductuales y de la personalidad (6,8), y desde el punto de vista neuropsicológico, el compromiso de memoria se presenta en estadios avanzados, siendo el compromiso de las funciones ejecutivas la característica principal en los estadios iniciales. La apatía es un síntoma temprano muy común de DFTvc; sin embargo, suele ser catalogado erróneamente como depresión.…”

Section: Introductionunclassified

Utilidad de la batería ejecutiva y cognición social de INECO en la evaluación de funciones ejecutivas de una serie de pacientes peruanos con demencia fronto-temporal, variante conductual.

Custodio¹,

Herrera-Pérez²,

Lira³

et al. 2015

Rev Neuropsiquiatr

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Behavioural-variant frontotemporal dementia: diagnosis, clinical staging, and management

Cited by 440 publications

References 125 publications

Does dysfunction of the mirror neuron system contribute to symptoms in amyotrophic lateral sclerosis?

Does dysfunction of the mirror neuron system contribute to symptoms in amyotrophic lateral sclerosis?

Frontotemporal Dementia: Implications for Understanding Alzheimer Disease

Utilidad de la batería ejecutiva y cognición social de INECO en la evaluación de funciones ejecutivas de una serie de pacientes peruanos con demencia fronto-temporal, variante conductual.

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