Behavioural studies on the methanol leaf extract of Securinega virosa (Euphorbiaceae) in mice

Aiyelero, O. M.; Abdu-Aguye, S. N.; Yaro, Alpha Seydou; Magaji, M.G.

doi:10.5897/jpp11.044

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…The extract facilitated sleep induction, as was also shown in another study with a model of diazepam-induced sleep. In this case, an extract at 100 mg/kg was shown to prolong the duration of diazepam-induced sleep without affecting the exploratory behavior or the motor coordination of mice [84]. These observations using experimental models are consistent with the traditional use of plant extract as a sedative in children and for mental illnesses.…”

Section: Antiepilepsy and Antipsychotic Activitiessupporting

confidence: 80%

Traditional Uses, Pharmacology and Phytochemistry of the Medicinal Plant Flueggea virosa (Roxb. ex Willd.) Royle

Bailly

2024

Future Pharmacology

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The white berry bush, officially Flueggea virosa (Roxb. ex Willd.) Royle is a medicinal plant distributed throughout tropical areas and traditionally used in Africa, India and China. Root decoctions are used to treat abdominal pain, whereas extracts from the aerial parts serve to treat liver and urinary diseases, inflammatory pathologies and diabetes, among other pathologies. Plant extracts have revealed antiparasitic, antimicrobial, antiepilepsy, antidiabetic, anticancer and analgesic effects. Three main categories of phytochemicals were isolated from F. virosa: polyphenols, with the lead product bergenin; terpenoids, such as the flueggenoids and related podocarpane-type diterpenoids; and many alkaloids derived from securinine and norsecurinine. A remarkable feature of S. virosa is the production of norsecurinine oligomers, including macromolecular tetramers and pentamers, such as fluevirosinines. The most potent anticancer alkaloid in the family is the dimeric indolizidine flueggine B, which was identified as a potential binder to α/β-tubulin dimer, which is a known target for securinine. This review highlights the diversity of phytochemicals identified from S. virosa and the potential therapeutic benefits of dimeric alkaloids. Studies are encouraged to further investigate the therapeutic properties of the lead compounds but also define and finesse the nutritional profile of the edible fruit.

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Section: Antiepilepsy and Antipsychotic Activitiessupporting

confidence: 80%

Traditional Uses, Pharmacology and Phytochemistry of the Medicinal Plant Flueggea virosa (Roxb. ex Willd.) Royle

Bailly

2024

Future Pharmacology

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“… Safe LD 50 > 10000 mg/kg in rats. LD 50 range of 20000–50000 mg/kg body weight Tatematsu et al (1991) ; Moshi et al (2000) ; Magaji et al (2007 , 2008a , b) ; Tanko et al (2008) ; Sanogo et al (2009) ; Yerima et al (2009) ; Aiyelero et al (2012) ; Garba et al (2013 , 2015) ; Abere et al (2014) ; Sempombe et al (2014) ; Zhang et al (2015) ; Shehu et al (2017) ; Ahmad et al (2018) ; Ajaib and Wahla (2018) ; Renu et al (2018) ; Misonge et al (2019) ; Salawu et al (2019) Euphorbiaceae Margaritaria discoidea (Baill.) Webster var.…”

Section: Methodsmentioning

confidence: 99%

Medicinal plants used for the management of respiratory diseases in Zimbabwe: Review and perspectives potential management of COVID-19

Nyagumbo¹,

Pote²,

Shopo³

et al. 2022

Physics and Chemistry of the Earth, Parts A/B/C

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Anxiolytic, analgesic and anti-inflammatory effects of Citrus maxima (Burm.) Merr. Seed extract in Swiss albino mice model

et al. 2023

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Background Citrus maxima (Burm.) Merr. is traditionally used for its diverse pharmacological properties. Therefore, there remains a possibility that the seed extract may contain some bioactive compounds. The present study was carried out to evaluate the anxiolytic, analgesic, and anti-inflammatory effects of methanolic seed extract of Citrus maxima (MECM). Method The effect of MECM on the rodent central nervous system was evaluated using the hole-board and elevated plus-maze method. Analgesic effect was measured with the acetic acid-induced writhing and formalin-induced paw licking method. The anti-inflammatory effect was examined using a formalin and carrageenan-induced mice paw edema model. Results The MECM at doses of 200 mg/kg and 400 mg/kg significantly (p < 0.01) increased the number of head dipping in the hole-board test. Additionally, the test subjects entered into the open arm and spent more time in it at an increased rate (p < 0.01) in the elevated plus-maze test. In the acetic acid-induced writhing method, the extract showed high potential (p < 0.001) as an analgesic agent. In the case of formalin-induced pain assessment, MECM demonstrated a significant effect (p < 0.01) at the early phase as a centrally acting anti-nociceptive agent and very high potential (p < 0.001) to reduce pain during the late phase as a peripherally acting analgesic. The extract also showed potency (p < 0.01) as an anti-inflammatory agent in formalin and carrageenan-induced mice paw edema test. Conclusion The findings of the current study indicate that MECM can be a promising new candidate for searching novel anxiolytic, analgesic, and anti-inflammatory compounds through further investigation.

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Behavioural studies on the methanol leaf extract of Securinega virosa (Euphorbiaceae) in mice

Cited by 4 publications

References 16 publications

Traditional Uses, Pharmacology and Phytochemistry of the Medicinal Plant Flueggea virosa (Roxb. ex Willd.) Royle

Traditional Uses, Pharmacology and Phytochemistry of the Medicinal Plant Flueggea virosa (Roxb. ex Willd.) Royle

Medicinal plants used for the management of respiratory diseases in Zimbabwe: Review and perspectives potential management of COVID-19

Anxiolytic, analgesic and anti-inflammatory effects of Citrus maxima (Burm.) Merr. Seed extract in Swiss albino mice model

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