Behavioural pharmacology of polygalasaponins indicates potential antipsychotic efficacy

Cognitive-enhancing effects of hydrolysate of polygalasaponin in SAMP8 mice

“…("Yuanzhi" in Chinese) is a well-known traditional Chinese medicine (TCM) herb, which was first documented in Shen Nong Ben Cao Jing, and its dried root has for a long time been traditionally used to treat memory loss in Asian countries (Howes and Houghton, 2003;Kwon et al, 2004;Adams et al, 2007). Recent pharmacological studies have shown that P. tenuifolia could improve memory impairment caused by scopolamine, stress, glutamate, and Aβ, and promote neuronal proliferation in normal brains (Chung et al, 2002;Lin et al, 2012;Li et al, 2014). Polygalasaponins, such as polygalasaponin B, F, G, and XXXII, are the main components responsible for the action of P. tenuifolia and have been shown to improve cognitive impairment in AD effectively (Ikeya et al, 2004;Xu et al, 2009;Wu et al, 2014).…”

Synthesis and Preliminary Pharmacological Evaluation of 2-[4-(Aryl substituted) piperazin-1-yl]-Nphenylacetamides: Potential Antipsychotics

“…The maximum possible score was 20. Recording was undertaken by an observer who was unaware of the specific drug treatments [11].…”

From Nutrition to Health: The Role of Natural Products – A Review

“…Polygalasaponins is an extract of a plant (Polygala tenuifolia Willdenow) that has been used as antipsychotic for hundred years in Korean traditional medicine. Polygalasaponin has been shown to have dopamine and serotonin receptor antagonism properties in vivo, suggesting its possible utility as an antipsychotic agent (Chung et al, 2002). …”