“Behavioural despair” in rats and mice: Strain differences and the effects of imipramine

Porsolt, Roger D.; Bertin, Aline; Jalfre, M

doi:10.1016/0014-2999(78)90414-4

Cited by 696 publications

(512 citation statements)

References 5 publications

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“…Ten minutes later, animals Forced swim test (FST). Mice were individually placed into a clear cylinder (15cm diameter, 30cm height) containing 20cm of water maintained at 24-25ºC, essentially as described by Porsolt et al 26 In this test, immobility of the mouse was scored in 2-mim bins for a total of 6min using a video camera system (Smart, Panlab).…”

Section: -Oh-dpat-induced Hypothermiamentioning

confidence: 99%

Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects

et al. 2011

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Depression is a major health problem worldwide. Most prescribed antidepressants, the selective serotonin reuptake inhibitors (SSRI) show limited efficacy and delayed onset of action, partly due to the activation of somatodendritic 5-HT 1A -autoreceptors by the excess extracellular serotonin (5-HT) produced by SSRI in the raphe nuclei. Interestingly, intranasal C-1A-siRNA administration produced the same effects, thus opening the way to the therapeutic use of C-1A-siRNA. Hence, C-1A-siRNA represents a new approach to treat mood disorders, as monotherapy or in combination with SSRI.3

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Section: -Oh-dpat-induced Hypothermiamentioning

confidence: 99%

Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects

et al. 2011

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“…The forced swim test was conducted as previously described [7,40]. The apparatus was a transparent Plexiglas cylinder 25 cm high, 20 cm diameter) filled halfway with water (24 ± 1°C ) such that the mouse could not touch the bottom with its tail.…”

Section: Forced Swim Testmentioning

confidence: 99%

Ontogeny of fear-, anxiety- and depression-related behavior across adolescence in C57BL/6J mice

Hefner¹,

Holmes²

2007

Behavioural Brain Research

167

123

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Adolescence is characterized by behavioral traits such as emotional lability and impulsivity that are associated with increased vulnerability to affective illness and addictions. Research in rodents has found that adolescent rats and mice differ from adults on measures of anxiety-like behavior, noveltyseeking and stress-responsivity. The present study sought to extend these data by evaluating fear-, anxiety-and depression-related behaviors in male C57BL/6J mice aged four (early adolescent), six (peri-adolescent) or eight (early adult) weeks of age. Age-groups were compared on: Pavlovian fear conditioning and extinction, anxiety-like behavior and exploratory locomotion (using elevated plusmaze and novel open field), and depression-related behavior (via forced swim test). Results showed that early adolescent mice exhibited enhanced fear conditioning, but extinguished at a similar rate as adults. There were no major differences in anxiety-like behavior across age-groups, although early adolescent and peri-adolescent mice exhibited less exploratory locomotion than adults. Depressionrelated immobility behavior in the forced swim test was lower in early adolescents than adult mice across three test exposures. Present findings in the C57BL/6J inbred strain add to growing evidence of changes in rodent fear-and stress-related behaviors across the developmental transition from juvenility through adulthood. Understanding the neural basis of these ontogenic changes could provide insight into factors could provide insight into the pathogenesis and treatment of affective disorders that have their origins in adolescence.

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“…The forced swim test (FST) served to assess depression-like behavior (Porsolt et al, 1978; Petit-Demouliere et al, 2005).…”

Section: Forced Swim Testmentioning

confidence: 99%

Regulatory Mechanisms of Fear Extinction and Depression-Like Behavior

Tronson

Schrick

Fischer

et al. 2007

Neuropsychopharmacol

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Human anxiety is frequently accompanied by depression, and when they co-occur both conditions exhibit greater severity and resistance to treatment. Little is known, however, about the molecular processes linking these emotional and mood disorders. Based on previously reported phosphorylation patterns of extracellular signal-regulated kinase (ERK) in the brain, we hypothesized that ERK's upstream activators intertwine fear and mood regulation through their hippocampal actions. We tested this hypothesis by studying the upstream regulation of ERK signaling in behavioral models of fear and depression. Wild-type and ERK1-deficient mice were used to study the dorsohippocampal actions of the putative ERK activators: mitogen-activated and extracellular signal-regulated kinase (MEK), protein kinase C (PKC), and cAMP-dependent protein kinase (PKA). Mice lacking ERK1 exhibited enhanced fear extinction and reduced depression caused by overactivation of ERK2. Both behaviors were reversed by inhibition of MEK, however the extinction phenotype depended on hippocampal, whereas the depression phenotype predominantly involved extrahippocampal MEK. Unexpectedly, inhibition of PKC accelerated extinction and decreased depression by ERK-independent mechanisms, whereas inhibition of PKA did not produce detectable molecular or behavioral effects in the employed paradigm. These results indicate that, contrary to fear conditioning but similar to mood stabilization, extinction of fear required upregulation of MEK/ERK and downregulation of ERK-independent PKC signaling. The dissociation of these pathways may thus represent a common mechanism for fear and mood regulation, and a potential therapeutic option for comorbid anxiety and depression.

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“Behavioural despair” in rats and mice: Strain differences and the effects of imipramine

Cited by 696 publications

References 5 publications

Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects

Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects

Ontogeny of fear-, anxiety- and depression-related behavior across adolescence in C57BL/6J mice

Regulatory Mechanisms of Fear Extinction and Depression-Like Behavior

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