Behaviour of the neutrophil to lymphocyte ratio in young subjects with acute myocardial infarction

Caimi, Gregorio; Presti, Rosalia Lo; Canino, Baldassare; Ferrera, E; Hopps, Eugenia

doi:10.3233/ch-151968

Cited by 13 publications

(18 citation statements)

References 37 publications

(53 reference statements)

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“…Among 7 studies of ACS outcome, 2 studies [ 28 , 32 ] reported OR of high versus low NLR, 2 studies [ 30 , 31 ] reported mean differences between ACS patients and controls, and 3 studies [ 18 , 27 , 29 ] reported both.…”

Section: Resultsmentioning

confidence: 99%

Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis

Angkananard

Anothaisintawee

McEvoy

et al. 2018

BioMed Research International

238

181

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Objective This systematic review aimed to measure the association between neutrophil lymphocyte ratio (NLR) and cardiovascular disease (CVD) risk. Methods Relevant studies were identified from Medline and Scopus databases. Observational studies with NLR as a study factor were eligible for review. The outcomes of interest were any type of CVD including acute coronary syndrome, coronary artery disease, stroke, or a composite of these cardiovascular events. Mean differences in NLR between CVD and non-CVD patients were pooled using unstandardized mean difference (USMD). Odds ratios of CVD between high and low NLR groups were pooled using a random effects model. Results Thirty-eight studies (n=76,002) were included. High NLR was significantly associated with the risks of CAD, ACS, stroke, and composite cardiovascular events with pooled ORs of 1.62 (95% CI: 1.38-1.91), 1.64 (95% CI: 1.30, 2.05), 2.36 (95% CI: 1.44, 2.89), and 3.86 (95% CI: 1.73, 8.64), respectively. In addition, mean NLRs in CAD, ACS, and stroke patients were significantly higher than in control groups. Conclusion High NLR was associated with CAD, ACS, stroke, and composite cardiovascular events. Therefore, NLR may be a useful CVD biomarker.

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Section: Resultsmentioning

confidence: 99%

Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis

Angkananard

Anothaisintawee

McEvoy

et al. 2018

BioMed Research International

238

181

View full text Add to dashboard Cite

show abstract

“…We found that decreasing NLR was associated with the disease progression, which was not congruent with previous studies. In one systematic review and meta-analysis, including thirtyeight article, high NLR was significantly associated with the risks of coronary artery disease, acute coronary syndrome, stroke and combined cardiovascular events 33 ; however, at the initial stage of the disease, NLR did not correlated with the cardiovascular determinants 34 . In Nordestgaard et al 35 study neutrophil and NLR were not significant determinants for Myocardial Infarction in the seemingly healthy population.…”

Section: Or (Ci 95%) P-value or (Ci 95%) P-value Or (Ci 95%) P-value mentioning

confidence: 99%

Determinant components of newly onset versus improved metabolic syndrome in a population of Iran

Lankarani

Honarvar

Keshani

et al. 2020

Sci Rep

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This study aimed to determine the risk factors related to regression and progression of metabolic syndrome, in a 4-year cohort study. A total of 540 individuals (≥ 18 years old) participated in both phase of the study. Participants were categorized into 3 categories of regressed, progressed and unchanged metabolic syndrome (MetS). Demographic, anthropometric and biochemical parameters were assessed for each individual in both phase. Variables differences (delta: Δ) between the two phase of study were calculated. Unchanged group was considered as baseline category. Based on IDF, MetS had been regressed and progressed in 42 participants (7.7%) and 112 (20.7%) participants respectively, in the second phase. More than 47% of people, whose MetS regressed, experienced also NAFLD regression. Results of multiple variable analysis revealed that increased age, positive Δ-TG, and Δ-FBS, significantly increased the odds of MetS progression based on IDF and ATP III definitions, while negative Δ-HDL and Δ-neutrophil to lymph ration increased the odds of progression. On the other hand, negative Δ-TG and positive Δ-HDL significantly increased the odds of Mets regression based of both IDF and ATP III. Management of hypertriglyceridemia, hyperglycemia, and HDL is a critical, non-invasive and accessible approach to change the trend of MetS.

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“…Previously, we have separately examined these parameters in the same population of patients with JMI. 23,24 This article is a part of the scientific project identified as ‘Sicilian study on juvenile myocardial infarction’. Myocardial infarction occurring at a relatively young age (45 years is the age limit generally accepted) has peculiarities in the pattern of risk factors and coronary lesions, which can justify its definition as a separate clinical condition.…”

Section: Introductionmentioning

confidence: 99%

Plasma Viscosity and NLR in Young Subjects with Myocardial Infarction: Evaluation at the Initial Stage and at 3 and 12 Months

Caimi

Montana

Andolina

et al. 2019

Clin Med Insights Cardiol

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In the “Sicilian study on juvenile myocardial infarction,” we had evaluated plasma viscosity (PV) and neutrophil/lymphocyte ratio (NLR) in patients with acute myocardial infarction (AMI) at the age of ⩽45 years. Now, we examined the relationship between these 2 parameters in 120 subjects (109 men and 11 women) aged ⩽45 years with recent AMI. The patients were classified according to the number of cardiovascular risk factors, the electrocardiographic criteria (ST-segment elevation myocardial infarction [STEMI] or non-ST-segment elevation myocardial infarction [NSTEMI]), and the extent of coronary stenosis, evaluated with coronary angiography. On fasting venous blood, we measured PV at the shear rate of 450 s −1 and NLR. The control group included 50 healthy subjects (mean age = 35.1 ± 7.8 years). At the initial stage, PV and NLR were significantly increased in comparison with controls. Subdividing AMI patients according to the median value of NLR, in the group with high NLR PV was significantly higher, whereas subdividing the patients according to the PV median value, NLR was not different between the 2 groups; 3 and 12 months after AMI, we observed only a significant decrease in NLR. Only PV was discriminant regarding the cardiovascular complications registered during an 18-month follow-up. The evaluation of PV may be of prognostic value in juvenile AMI.

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Behaviour of the neutrophil to lymphocyte ratio in young subjects with acute myocardial infarction

Cited by 13 publications

References 37 publications

Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis

Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis

Determinant components of newly onset versus improved metabolic syndrome in a population of Iran

Plasma Viscosity and NLR in Young Subjects with Myocardial Infarction: Evaluation at the Initial Stage and at 3 and 12 Months

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