Behaviour of some indicators of oxidative stress in postmenopausal and fertile women

Signorelli, Salvatore Santo; Neri, Sergio; Sciacchitano, Salvatore; Pino, Luigi Di; Costa, Maria Pia; Marchese, Giuseppe; Celotta, Gabriella; Cassibba, Nunziata; Pennisi, Giuseppe; Caschetto, S

doi:10.1016/j.maturitas.2005.03.001

Cited by 135 publications

(101 citation statements)

References 28 publications

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“…Our results are consistent with the findings of a previous study comparing MDA levels between fertile and postmenopausal age groups [19]. Furthermore, two recent reports, investigating the effect of surgical menopause on oxidant and antioxidant status of perimenopausal patients, revealed that MDA levels were increased after surgical menopause [18,20].…”

Section: Discussionsupporting

confidence: 93%

“…Although an increase in plasma levels of MDA, a marker of lipid peroxidation, in the postmenopausal period has been previously demonstrated [18][19][20], to the best of our knowledge this has been the first study to demonstrate menopause-related increase in plasma AOPP levels -a novel marker of oxidative protein damage reported to be associated with increased cardiovascular risk. In our study, mean plasma AOPP levels were significantly higher in postmenopausal as compared to premenopausal women, suggesting that it can be used as a marker in studies investigating cardiovascular risk in postmenopausal period.…”

Section: Discussionmentioning

confidence: 68%

“…Estrogens also have favorable effects on vascular oxidative stress by either increasing bioavailability of the vasoprotective molecule endothelium-derived nitric oxide or by modulating the expression and function of enzymes producing ROS, as well as antioxidant enzymes [27]. An increase in vascular oxidative stress in women after menopause has been reported in several studies [18][19][20]28]. Furthermore, hormone replacement therapy has been shown to improve oxidative stress status of postmenopausal women [18,[29][30][31][32].…”

Section: Discussionmentioning

confidence: 99%

“…Although increased blood levels of lipid peroxidation products (malondialdehyde levels) have been reported in postmenopausal women [18][19][20], there is only one study reporting AOPP levels in postmenopausal women [21].The aim of the study was to measure AOPP and MDA levels in pre and postmenopausal women.…”

Section: Objectivesmentioning

confidence: 99%

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Advanced oxidation protein products and malondialdehyde — the new biological markers of oxidative stress — are elevated in postmenopausal women

Çakır

Goktas²,

Mutlu

et al. 2016

Ginekol Pol

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Objectives: The aim of the study was to measure advanced oxidation protein products (AOPPs) as markers for oxidative stress to evaluate cardiovascular risk in pre-and postmenopausal women and to compare the results with malondialdehyde (MDA) levels. Material and methods:Twenty premenopausal women and 84 naturally postmenopausal patients were enrolled in the study. AOPP and MDA plasma levels were measured. The postmenopausal group was further subdivided into two groups: postmenopausal age of 40-49 and of 50-59 years. AOPP and MDA levels were compared between premenopausal, 40-49 and 50-59 year old menopausal women.Results: Plasma AOPP and MDA levels in postmenopausal women were increased when compared with their premenopausal peers (123.83 ± 55.51 µmol/L vs. 61.59 ± 16.42 µmol/L and 6.50 ± 1.05 µmol/L vs. 5.98 ± 0.77 µmol/L; respectively).

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Objectivesmentioning

confidence: 99%

See 2 more Smart Citations

Advanced oxidation protein products and malondialdehyde — the new biological markers of oxidative stress — are elevated in postmenopausal women

Çakır

Goktas²,

Mutlu

et al. 2016

Ginekol Pol

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show abstract

“…Analytically, serum concentrations of inflammatory cytokines and pro-oxidant biomarkers such as oxidized lipoproteins (ox LDL), 4-hydroxynenal and MDA were found to be higher in postmenopausal women than in premenopausal women (87). In contrast, GSH and glutathione transferase (GST), which are effective in the removal of free radicals, are reduced in oocytes with age (88).…”

Section: Ovarian Agingmentioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: Aging and anti-aging: a Combo-Endocrinology overview

Diamanti-Kandarakis

Dattilo²,

Macut

et al. 2017

European Journal of Endocrinology

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Aging and its underlying pathophysiological background has always attracted the attention of the scientific society. Defined as the gradual, time-dependent, heterogeneous decline of physiological functions, aging is orchestrated by a plethora of molecular mechanisms, which vividly interact to alter body homeostasis. The ability of an organism to adjust to these alterations, in conjunction with the dynamic effect of various environmental stimuli across lifespan, promotes longevity, frailty or disease. Endocrine function undergoes major changes during aging, as well. Specifically, alterations in hormonal networks and concomitant hormonal deficits/excess, augmented by poor sensitivity of tissues to their action, take place. As hypothalamic-pituitary unit is the central regulator of crucial body functions, these alterations can be translated in significant clinical sequelae that can impair the quality of life and promote frailty and disease. Delineating the hormonal signaling alterations that occur across lifespan and exploring possible remedial interventions could possibly help us improve the quality of life of the elderly and promote longevity.

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Lipid profile, ox‐LDL, and LCAT activity in patients with endometrial carcinoma and type 2 diabetes: The effect of concurrent disease based on a case–control study

Qahremani,

Rabizadeh,

Mirmiranpoor

et al. 2023

Health Science Reports

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Background and AimThe role of lecithin: cholesterol acyltransferase (LCAT) and oxidized low‐density lipoprotein (ox‐LDL) in endometrial cancer (EC) or EC with concurrent type 2 diabetes is still unclear. This study investigated the LCAT activity, ox‐LDL, and lipid profile in EC patients with or without type 2 diabetes and compared them with healthy individuals and patients with type 2 diabetes alone.MethodsIn this cross‐sectional, case–control study, 93 female participants were recruited. The participants were divided into four groups, including EC with type 2 diabetes (n = 19), EC without type 2 diabetes (n = 17), type 2 diabetes (n = 31), and healthy controls (n = 26). Sociodemographic information, the LCAT activity, triglyceride (TG), total cholesterol, high‐density lipoprotein cholesterol (HDL‐C), low‐density lipoprotein cholesterol (LDL‐C), and ox‐LDL levels were collected. One‐way analysis of variance and analysis of covariance, Student's t‐test, Mann–Whitney U‐test, and χ2‐test were used to compare demographic features and laboratory results among studied groups. Regression analyses were also performed to evaluate the interaction effect between EC and type 2 diabetes on serum LCAT activity.ResultsThe LCAT activity was significantly lower, and ox‐LDL levels were significantly higher in all patient groups compared to the healthy controls (p < 0.001). EC patients had significantly lower LCAT activity and higher ox‐LDL levels than type 2 diabetes and healthy groups (p < 0.05). Higher levels of TG and lower levels of HDL‐C were observed in all patient groups compared to the healthy group (all p < 0.001). Patients with EC and concomitant type 2 diabetes had significantly lower serum LDL‐C levels than healthy and type 2 diabetes groups (p < 0.05).ConclusionsThe combination of EC and type 2 diabetes had a subadditive effect on LCAT activity and ox‐LDL level. The lowest LCAT activity and the highest ox‐LDL levels were observed in patients with EC and concurrent type 2 diabetes.

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Behaviour of some indicators of oxidative stress in postmenopausal and fertile women

Cited by 135 publications

References 28 publications

Advanced oxidation protein products and malondialdehyde — the new biological markers of oxidative stress — are elevated in postmenopausal women

Advanced oxidation protein products and malondialdehyde — the new biological markers of oxidative stress — are elevated in postmenopausal women

MECHANISMS IN ENDOCRINOLOGY: Aging and anti-aging: a Combo-Endocrinology overview

Lipid profile, ox‐LDL, and LCAT activity in patients with endometrial carcinoma and type 2 diabetes: The effect of concurrent disease based on a case–control study

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