Behaviour of Plasma Renin Activity and Aldosterone During the First 72 H of Life

Sparano, Francesco; Sciarra, F; Natoli, G.; Mercuri, Maria A.; Odoardi, A.; Colangelo, E.

doi:10.1111/j.1365-2265.1978.tb01496.x

Cited by 12 publications

(6 citation statements)

References 18 publications

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“…as well as in human neonates (Beitins et al, 1972 ;Dillon et al, 1976 ;Tochigi et al, 1976 ;Sparano et al, 1978 ;Sulyok et al, 1979 Plasma sodium levels decreased from 144 + 2 mM at birth to 139 + 1 mM (P < 0.05) on day 6 to 137 ± 1 mM (P < 0.05) on day 7 ( fig. 11.…”

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confidence: 92%

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Sodium and potassium balances and plasma aldosterone levels in newborn calves

Safwate¹,

Davicco²,

Barlet³

et al. 1982

Reprod. Nutr. Dévelop.

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confidence: 92%

“…1) Dillon et al, 1976 ;Sparano et al, 1978) than in those delivered by cesarean section (Lammintausta et al, 1977 ;Lumbers and Reid, 1977 ;Oparil et al, 1978). Plasma concentrations of angiotensin II are also higher in the nursing infant than in the adult (Kotchen et al, 1972 ;BroughtonPipkin and Symonds, 1977).…”

mentioning

confidence: 99%

Sodium and potassium balances and plasma aldosterone levels in newborn calves

Safwate¹,

Davicco²,

Barlet³

et al. 1982

Reprod. Nutr. Dévelop.

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“…Serum renin concentration, assessed by radioimmunometric assay (Renin 3 Generation; Bio-Rad, ScheringCis-Bio, France), was 385 pg/mL in the donor and 296 pg/mL in the recipient, the mean Ϯ 95% confidence interval for neonates being 31.43 Ϯ 27.3 pg/mL in our institution. Serum aldosterone concentration, measured using a RIA kit (ALDO-CTK-2; Schering-Cis-Bio), was 292 pg/mL in the donor and 248 pg/mL in the recipient (within normal range) (18).…”

Section: Case Reportmentioning

confidence: 99%

Paradoxic Activation of the Renin-Angiotensin System in Twin-Twin Transfusion Syndrome: An Explanation for Cardiovascular Disturbances in the Recipient

et al. 2005

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Despite advances in treatment, twin-to-twin transfusion syndrome (TTTS) still carries a high risk for perinatal mortality and morbidity. Simple blood transfer from the donor to the recipient twin cannot explain all of the features of this disease, in particular the recipient's hypertensive cardiomyopathy. We report a case in which TTTS resulted in preterm delivery with early neonatal death of both twins, allowing assessment of the renin angiotensin system (RAS) status of each fetus, both by cord blood renin and aldosterone assay and by renal immunohistochemistry. The donor had severe oliguria/oligohydramnios, whereas the recipient, in addition to severe polyuria/ polyhydramnios, had cardiomyopathy, atrioventricular regurgitation, and ascites. Although immunohistochemistry demonstrated that renal secretion of renin was up-regulated in the donor and down-regulated in the recipient, cord blood levels of renin and aldosterone were similar, with high renin levels in both twins. This observation supports the hypothesis that despite renal RAS down-regulation, the recipient is exposed to RAS effectors elaborated in the donor and transferred via placental shunts. This may contribute to cardiomyopathy and hypertension in the recipient, which cannot be accounted for by hypervolemia alone. We thus hypothesized that in TTTS, the recipient's hypertensive cardiomyopathy could be due to a mechanism similar to the classical model of hypertension referred to as "2 kidneys-1 clip." Thus the hypovolemic donor twin, comparable to the clipped kidney, produces vasoactive hormones that compromise the recipient, comparable to the normal kidney, causing hypertension and cardiomyopathy. (Pediatr Res 58: 685-688, 2005) Abbreviations Ang II, angiotensin II RAS, renin-angiotensin system TTTS, twin-to-twin transfusion syndrome Twin-to-twin transfusion syndrome (TTTS) is a severe disease that complicates 15% of monochorionic twin pregnancies. Despite advances in perinatal management, TTTS still carries a high risk for both fetal and neonatal mortality and morbidity (1-3). It leads to widespread renovascular manifestations in the donor twin, such as oliguria and oligohydramnios, and in the recipient to polyuria, polyhydramnios, and occasionally, systemic hypertension, heart failure, and hydrops. Although TTTS certainly originates in unbalanced blood flow through placental anastomoses (4 -6), the detailed mechanism that leads to its complex fetal cardiovascular (7-10) and renal disturbances remains unclear. In particular, hypervolemia alone does not account for myocardial hypertrophy in the recipient, which can be severe enough to result in obstructive valvular lesions (7,9). Hypervolemia alone also fails to explain profound vascular disturbances in the recipient fetus, such as systemic hypertension, as suggested by postmortem findings (11)

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“…However transplacental transfer from the ewe to its foetuses was found to be negligible (Moncaup et al, 1980 ;Wintour et al, 1980). No relationship could be demonstrated between plasma Na and K concentrations and plasma aldosterone levels in lambs either before or after birth (Moncaup et al, 1980 (Giry and Delost, 1977) as well as in human infants (Sparano et al, 1978), foals (Giry et al, 1979), mice (Loctin, 1980) and calves (Safwate et al, 1982). Under our experimental conditions as in lambs kept with their dams after birth (Moncaup et al, 1980), no increase in plasma aldosterone concentration was observed between birth and day 7 in either the 9 NB lambs or the 10 DCS lambs ( fig.…”

Section: Introductionmentioning

confidence: 95%

Electrolyte balance, mode of delivery and plasma aldosterone levels in newborn lambs

Safwate¹,

Davicco²,

Dalle³

et al. 1984

Reprod. Nutr. Dévelop.

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Summary. Plasma aldosterone, sodium (Na) and potassium (K) concentrations, daily Na and K intakes, and urinary and faecal excretion were measured during the first week of postnatal life in 9 lambs naturally born at term (145 days of gestation) and in 10 lambs delivered by caesarean section on day 145 (6 lambs) or on day 139 (4 lambs) of gestation.Plasma aldosterone, Na and K concentrations showed no significant variation during the experimental period in any group of lambs, and there was no significant difference concerning these parameters among the three groups.Na and K balances were always positive during the experimental period in naturally born lambs. It was negative on days 4 and 6 postdelivery in those delivered by caesarean section on days 145 and 139 of gestation, respectively. This was probably due to the lower daily Na and K intakes measured in these 10 lambs compared to the 9 control lambs : urinary output and urinary Na and K excretion were lower in the two groups of lambs delivered by caesarean section, while Na and K urinary concentrations were not different in any group.Introduction.

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Behaviour of Plasma Renin Activity and Aldosterone During the First 72 H of Life

Cited by 12 publications

References 18 publications

Sodium and potassium balances and plasma aldosterone levels in newborn calves

Sodium and potassium balances and plasma aldosterone levels in newborn calves

Paradoxic Activation of the Renin-Angiotensin System in Twin-Twin Transfusion Syndrome: An Explanation for Cardiovascular Disturbances in the Recipient

Electrolyte balance, mode of delivery and plasma aldosterone levels in newborn lambs

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