Since U-boot slabs can cover a large area without the need for columns, they are known as a favorable option for architects. On the other hand, from the point of view of the structural and earthquake engineer, reducing the number of columns can lead to the reduction of the additional resistance factor of the structure, which may lead structures to risks during an earthquake. Considering that published comprehensive studies in this field are limited, therefore, in this paper, the nonlinear dynamic behavior of concrete structures with U-boot slabs will be investigated. For this purpose, the behavior of short to medium-order structures will be investigated. Correspondingly, based on the obtained results, the necessary recommendations in this field will be proposed to improve this system. These recommendations are proposed with the approach of architectural requirements as well as structural requirements.