Behaviour of nonresorbable bioactive glass–ceramic implanted into long bone defects: comparison with cancellous allografts

Šponer, Pavel; Urban, K; Urbanová, E; Karpas, K; Mathew, Pradeep G.

doi:10.1007/s00402-009-0839-3

Cited by 9 publications

(13 citation statements)

References 20 publications

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“…Four hundred and sixty-three articles were identified for the qualitative systematic review. Sixty-two articles were eligible for the quantitative systematic review [3, 6, 8–67]. The rest of the articles were excluded, including: 97 articles that were not in English or French [68–164], one randomized clinical trial [165], one prospective study [166], seven case series [167–173], 174 case reports [2, 174–346], 10 basic science articles [5, 347–355], 26 articles that did not discuss UBC treatment [1, 356–380], 17 articles that did not represent clear data on healing [381–397], 18 review articles [4, 398–414], one article that was a reprint [415], three commentary articles [416–418], 36 articles with a sample size smaller than 15 [419–454], and ten articles with possibility of shared cohort [455–464] (Fig.…”

Section: Resultsmentioning

confidence: 99%

Treatment of unicameral bone cyst: Systematic review and meta analysis

Kadhim

Thacker

Kadhim³

et al. 2014

Journal of Children's Orthopaedics

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PurposeDifferent treatment modalities have been utilized to treat unicameral bone cyst (UBC), but evidence has not been fully described to support one treatment over another and the optimal treatment is controversial. The aim of this quantitative systematic review was to assess the effectiveness of different UBC treatment modalities.MethodsWe utilized Pubmed to isolate retrospective studies on patients with UBC who received any kind of treatment. The included studies needed to have a minimum sample size of 15 patients, and have provided data on radiographic healing outcome.ResultsSixty-two articles were selected for the meta-analysis from a total of 463 articles. The cumulative sample size was 3,211 patients with 3,217 UBC, and male to female ratio was 2.2:1. The summary or pool estimate of methylprednisolone acetate (MPA) injection resulted in a healing rate of (77.4 %) that was comparable to bone marrow injection (77.9 %). A higher healing rate was observed with MPA injection when inner wall disruption was performed. The pool estimate of bone marrow with demineralized bone matrix injection was high (98.7 %). UBC healing rate after surgical curettage was comparable whether autograft or allograft was utilized (90 %). UBC treatment with flexible intramedullary nails without curettage provided almost 100% healing rate, while continuous decompression with cannulated screws provided 89 % healing rate. Conservative treatment indicated a healing rate of 64.2, 95 % CI (26.7–101.8).ConclusionsActive treatment for UBC provided variable healing rates and the outcomes were favorable relative to conservative treatment. Due to the heterogeneity of the studies and reporting bias, the interpretation of these findings should be handled with caution.

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Section: Resultsmentioning

confidence: 99%

Treatment of unicameral bone cyst: Systematic review and meta analysis

Kadhim

Thacker

Kadhim³

et al. 2014

Journal of Children's Orthopaedics

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“…O'Donnell et al also found that the crystalline phase of biomimetic HCA occurred rapidly in SBF as the phosphate content increased in the soda-limephosphosilicate glass system. [41] However, it is known that increasing P 2 O 5 contents in BGs increased the apatite phase in the BGCs after sintering treatment, and this would reduce the resorption rate in the BGCs [42][43][44]. Recently, some investigations has demonstrated that the bioactivity and resorption rate of β-CaSiO 3 ceramics and β-CaSiO 3 /CaB 2 O 4 BGCs were much higher than that of β-tricalcium phosphate and apatite, and these porous materials may significantly enhance the spinal fusion or calvarial defect repair in rabbit model [23,45].…”

Section: Discussionmentioning

confidence: 98%

Incorporation of B2O3 in CaO-SiO2-P2O5 bioactive glass system for improving strength of low-temperature co-fired porous glass ceramics

Yang

Zhang

Chen

et al. 2012

Journal of Non-Crystalline Solids

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“…An allograft bonegraft has to be both safe in use and to possess acceptable mechanical and biological properties. In an effort to overcome the limitations of autografts and allografts, a variety of synthetic bone-graft substitutes have been developed [2].…”

Section: Introductionmentioning

confidence: 99%

In vivo behaviour of low-temperature calcium-deficient hydroxyapatite: comparison with deproteinised bovine bone

Šponer

Strnadová

Urban

2010

International Orthopaedics (SICOT)

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This study aims to evaluate in detail the biological osteoconductive properties of the low-temperature synthetic porous calcium-deficient hydroxyapatite and to compare it with the biological apatite. Bone reactions to granules of similar sizes of the low-temperature hydroxyapatite and commercially available non-sintered deproteinized bovine bone were compared. Two different temperatures were used to fabricate two batches of newly developed porous hydroxyapatite with different carbonate groups content and specific surface area. The histological analysis of specimens with histomorphometry was performed at different time after in vivo implantation. Based on histological analysis, the level of bone formation in the spaces between the implanted granules and through the interconnected pores of all implanted materials within a cortical region (bone area ingrowth 72-85 %) was several-fold higher than within a cancellous bone site (bone area ingrowth 16-28 %) at three and six months after implantation. Within the cancellous bone site, bone coverage of the implanted material at six months was significantly higher in hydroxyapatite material fabricated using low-temperature synthesis and subsequent processing at 150°C than in hydroxyapatite scaffold developed using low-temperature synthesis with subsequent processing at 700°C or deproteinized bovine bone. According to our study, the bioactive properties of the low-temperature calcium-deficient hydroxyapatite are comparable with the biological apatite. The favourable influence of a high specific surface area of a low-temperature calcium-deficient hydroxyapatite on in vivo bone formation was emphasized.

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Behaviour of nonresorbable bioactive glass–ceramic implanted into long bone defects: comparison with cancellous allografts

Abstract: The implantation of the nonresorbable glass-ceramic material into the diaphyseal defects of long bones is not suitable based on our study.

Cited by 9 publications

References 20 publications

Treatment of unicameral bone cyst: Systematic review and meta analysis

Treatment of unicameral bone cyst: Systematic review and meta analysis

Incorporation of B2O3 in CaO-SiO2-P2O5 bioactive glass system for improving strength of low-temperature co-fired porous glass ceramics

In vivo behaviour of low-temperature calcium-deficient hydroxyapatite: comparison with deproteinised bovine bone

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