Behaviour, chemosignals and endocrine functions in male mice infected with tick-borne encephalitis virus

Мошкин, М. П.; Gerlinskaya, L. A.; Морозова, О. В.; Бахвалова, В. Н.; Evsikov, V. I.

doi:10.1016/s0306-4530(01)00096-8

Cited by 57 publications

(32 citation statements)

References 13 publications

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“…Volatile compounds released by infected animals can reduce the contacts between animals in the same group and thus prevent dissemination of the infection [4,12]. Our findings indicate that contrary to expectations, postirradiation secretions were attractive for intact animals irrespective of the genotype of mice producing these secretions.…”

Section: Resultsmentioning

confidence: 66%

Postirradiation volatile secretions of mice: syngeneic and allogeneic immune and behavioral effects

2004

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The immune response in immunologically and olfactorily high- and low-reactive CBA and C57Bl/6 mice is almost similarly decreased after exposure to volatile secretions of syngeneic animals exposed to ionizing radiation in a dose of 4 Gy. In the preference/avoidance test intact animals prefer secretions of irradiated syngeneic and allogeneic animals to those of intact animals, while without irradiation animals of both strains prefer syngeneic secretions. C57Bl/6 mice differ from CBA animals by lower sensitivity.

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Section: Resultsmentioning

confidence: 66%

Postirradiation volatile secretions of mice: syngeneic and allogeneic immune and behavioral effects

2004

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“…amygdala, hippocampus, and hypothalamus) as well as suppression of 5-HT neurotransmission (Ceccaldi et al, 1993;Dietzschold et al, 2001). Male mice infected with tick-borne encephalitis (TBE) virus have elevated concentrations of circulating testosterone and are more aggressive than uninfected mice (Moshkin et al, 2002). Seoul virus increases the testosterone concentrations and the expression of aggression in male rats (Hinson et al, 2004;Klein et al, 2004); whether Seoul virus suppresses 5-HT activity in the CNS, similar to rabies virus, requires further investigation.…”

Section: Discussionmentioning

confidence: 99%

Elevated testosterone and reduced 5-HIAA concentrations are associated with wounding and hantavirus infection in male Norway rats

Easterbrook

Kaplan

Glass

et al. 2007

Hormones and Behavior

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Among rodents that carry hantaviruses, males are more likely to engage in aggression and to be infected than females. One mode of hantavirus transmission is via the passage of virus in saliva during wounding. The extent to which hantaviruses cause physiological changes in their rodent host that increase aggression and, therefore, virus transmission has not been fully documented. To assess whether steroid hormones and neurotransmitters contribute to the correlation between aggression and Seoul virus infection, Norway rats were trapped in Baltimore, Maryland and wounding, infection status, steroid hormones, and concentrations of neurotransmitters, including norepinephrine (NE), dopamine (DA), 3,4-dihydroxyphenol acetic acid (DOPAC), serotonin (5-HT), and 5-hydroxyindole-3-acetic acid (5-HIAA) in select brain regions were examined. Older males and males with high-grade wounds were more likely to have anti-Seoul virus IgG and viral RNA in organs than either juveniles or adult males with less severe wounds. Wounded males had higher circulating testosterone, lower hypothalamic 5-HIAA, and lower NE in the amygdala than males with no wounds. Infected males had higher concentrations of testosterone, corticosterone, NE in the hypothalamus, and DOPAC in the amygdala than uninfected males, regardless of wounding status. In the present study, wounded males that were infected with Seoul virus had elevated testosterone and reduced 5-HIAA concentrations, suggesting that these neuroendocrine mechanisms may contribute to aggression and the likelihood of transmission of hantavirus in natural populations of male Norway rats.

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“…The effects for increased transmission were also investigated with respect to increased level of odor in vertebrate hosts infected with TBEV. It was found that the viral infection increased the blood level of testosterone, which, in turn, rendered infected male rodents to be more aggressive and attractive to estrous females, thus enhancing viral dissemination (221).…”

Section: Febrile Condition and Enhanced Attractiveness Of Virus-infecmentioning

confidence: 99%

Biological Transmission of Arboviruses: Reexamination of and New Insights into Components, Mechanisms, and Unique Traits as Well as Their Evolutionary Trends

2005

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SUMMARY Among animal viruses, arboviruses are unique in that they depend on arthropod vectors for transmission. Field research and laboratory investigations related to the three components of this unique mode of transmission, virus, vector, and vertebrate host, have produced an enormous amount of valuable information that may be found in numerous publications. However, despite many reviews on specific viruses, diseases, or interests, a systematic approach to organizing the available information on all facets of biological transmission and then to interpret it in the context of the evolutionary process has not been attempted before. Such an attempt in this review clearly demonstrates tremendous progress made worldwide to characterize the viruses, to comprehend disease transmission and pathogenesis, and to understand the biology of vectors and their role in transmission. The rapid progress in molecular biologic techniques also helped resolve many virologic puzzles and yielded highly valuable data hitherto unavailable, such as characterization of virus receptors, the genetic basis of vertebrate resistance to viral infection, and phylogenetic evidence of the history of host range shifts in arboviruses. However, glaring gaps in knowledge of many critical subjects, such as the mechanism of viral persistence and the existence of vertebrate reservoirs, are still evident. Furthermore, with the accumulated data, new questions were raised, such as evolutionary directions of virus virulence and of host range. Although many fundamental questions on the evolution of this unique mode of transmission remained unresolved in the absence of a fossil record, available observations for arboviruses and the information derived from studies in other fields of the biological sciences suggested convergent evolution as a plausible process. Overall, discussion of the diverse range of theories proposed and observations made by many investigators was found to be highly valuable for sorting out the possible mechanism(s) of the emergence of arboviral diseases.

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Behaviour, chemosignals and endocrine functions in male mice infected with tick-borne encephalitis virus

Cited by 57 publications

References 13 publications

Postirradiation volatile secretions of mice: syngeneic and allogeneic immune and behavioral effects

Postirradiation volatile secretions of mice: syngeneic and allogeneic immune and behavioral effects

Elevated testosterone and reduced 5-HIAA concentrations are associated with wounding and hantavirus infection in male Norway rats

Biological Transmission of Arboviruses: Reexamination of and New Insights into Components, Mechanisms, and Unique Traits as Well as Their Evolutionary Trends

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