Behaviour changes in a transgenic model of Huntington's disease

Klivényi, Péter; Bende, Zsuzsanna; Hartai, Zsuzsanna; Penke, Zsuzsanna; Németh, Hajnalka; Toldi, József; Vécsei, László

doi:10.1016/j.bbr.2006.01.003

Cited by 27 publications

(18 citation statements)

References 19 publications

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“…In another HD model with rapid onset, N171-82Q, mice fail to gain weight by 12 weeks, and show gait abnormalities, hypokinesis and tremor from 12 weeks, leading to death at 20-24 weeks. However, the earliest sign of disease onset in this model may be reduced rearing behaviour at eight weeks (Klivenyi et al 2006). Full-length models like knock-in or YAC transgenic mice show a less severe and a more progressive disease course than the N-terminal models, making them better models of the human disease.…”

Section: Discussion (A) Disease Progression In Se and Re Cagesmentioning

confidence: 99%

Towards humane end points: behavioural changes precede clinical signs of disease in a Huntington's disease model

et al. 2008

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The number of animals used in science is increasing, bringing a concomitant obligation to minimize suffering. For animals with progressive conditions, euthanasia at a 'humane end point' is advised if the end point is scientifically valid, predictive and accurate. Our aim was to test the hypothesis that behavioural changes would reliably precede clinical signs of disease in a progressive neurological model, using retrospective analysis. We observed 100 pair-housed female R6/1 transgenic Huntington's disease (HD) mice and 28 pair-housed female wild-type (WT) mice in standard-or resource-enriched cages. Disease progression was monitored until one member of each HD pair reached a pre-defined end point based on pathological symptoms (HD end). This mouse was then euthanized together with its cage mate (HD other) and any matched WT pairs. At euthanasia, HD mice had significantly greater absolute and relative organ weights, and significantly higher a1 acid glycoprotein concentrations than WT mice, indicating reduced welfare. HD mice initially showed significantly greater use of cage resources than WT mice but this declined progressively. Steeper declines, and earlier cessation, in the use of some climbing and exploration resources occurred in the HD end mice compared with the HD other mice. Behavioural change can be an early indicator of disease onset.

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Section: Discussion (A) Disease Progression In Se and Re Cagesmentioning

confidence: 99%

Towards humane end points: behavioural changes precede clinical signs of disease in a Huntington's disease model

et al. 2008

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show abstract

“…A kísérleti állatot egy felülről nyitott, kerek (80 cm átmérőjű, 45 cm magas), műanyag, feketére festett aréna közepére helyezzük, és mérjük a centrumban és a periférián eltöltött időt százalékban, a teljes megtett utat, az átlagsebességet és a mozgással eltöltött időt, az állat felágaskodásainak, vakarózásainak, a szippantásainak/szimatolásainak, freezing-eknek és a székletürítéseinek a számát a teszt 5 perces vizsgálati periódusában [106].…”

Section: Open-field Tesztunclassified

“…A kísérleti munkába bevont állatok viselkedés mintázatainak követéséhez a nemzetközi standardokat alkalmaztuk [106,107,108].…”

Section: In Vivo Vizsgálati Protokollok Kialakítása éS Standardizálásaunclassified

A környezeti terhelések és patomechanizmusok kapcsolata

Pálföldi

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“…OF tests [116] were performed to determine the effects of ClB exposure on the anxietyrelated behaviors, spontaneous locomotor activity and explorative behavior of individual animals. Each rat was placed at the center of a circular (diameter 80 cm, height 45 cm), plastic, black-painted arena open at the top, and the following behavioral elements were detected by the EthoVision and/or staff members manually: the percentages of time spent in the centre and periphery, total distance moved and the mean velocity, and the total durations and numbers of rearing, grooming, sniffing, freezing and defecation episodes.…”

Section: Of Testsmentioning

confidence: 99%

Study of neurogenic involvement in arginine-vasopressin and oxytocin release under basal and environmentally stimulated conditions

Nagyéri¹

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Behaviour changes in a transgenic model of Huntington's disease

Cited by 27 publications

References 19 publications

Towards humane end points: behavioural changes precede clinical signs of disease in a Huntington's disease model

Towards humane end points: behavioural changes precede clinical signs of disease in a Huntington's disease model

A környezeti terhelések és patomechanizmusok kapcsolata

Study of neurogenic involvement in arginine-vasopressin and oxytocin release under basal and environmentally stimulated conditions

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