Behaviour at the peritoneal interface of next-generation prosthetic materials for hernia repair

Pascual, Gemma; Benito-Martínez, Selma; Rodrı́guez, Marta; Pérez-Köhler, Bárbara; García-Moreno, Francisca; Bellón, Juan M.

doi:10.1007/s00464-021-08320-5

Cited by 5 publications

(5 citation statements)

References 43 publications

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“…As a result of advanced perioperative care and the development of surgical techniques, cancer patients once considered inoperable are now often selected as a candidate for surgery, leading to a dramatic reduction in oncologic burden and providing the patients a chance to receive additional adjuvant chemotherapy [2,3]. This case exemplifies such achievement in multidisciplinary care.…”

Section: Discussionmentioning

confidence: 91%

“…The product is a bilayered construct composed of non-absorbable polyester monofilament and a bioabsorbable collagen film. The absorbable collagen side enables direct application to the bowel and subsequently promotes neo-peritonization through mesothelial cell migration along the bowel contact surface [3]. On the outer surface, the clinging effect of the nonabsorbable polyester mesh to abdominal soft tissue results in broad adhesion, preventing bowel hernia [9].…”

Section: Discussionmentioning

confidence: 99%

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Abdominal Wall Reconstruction in a Terminal-Stage Peritoneal Cancer Patient after Emergency Debulking Procedure: A Case Report

et al. 2022

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Late-stage peritoneal cancer is a grave disease with a high morbidity rate; palliative care is the mainstay of treatment. In this article, we present a case of a terminal-stage cancer patient with sustained growth of the tumor. The mass was large enough to invade into the abdominal wall, and cause bowel obstruction as well as major vessel compression. From supportive care, we made a rapid pivot to emergent en bloc resection of the mass with a significant portion of the abdominal wall in one piece. After resection, a major part of the abdominal layers was deficient and required reconstruction. Due to rapid deterioration of the patient’s condition, we changed our plan from autologous reconstruction to prosthesis-based reconstruction. Through this report, we share our decision-making process for reconstruction method selection, and practical considerations in the intraoperative setting.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Abdominal Wall Reconstruction in a Terminal-Stage Peritoneal Cancer Patient after Emergency Debulking Procedure: A Case Report

et al. 2022

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“…Fourteen publications identified by this scoping review involved preclinical studies in a variety of animal models and species, including pigs, rats, rabbits, sheep, mice, and vervets ( Figure 2 , and Table 1 ) ( 6 , 23 , 24 , 26 , 36 , 37 , 43 – 49 , 89 ). Three of these studies ( n = 3) contained both a benchtop component and a preclinical component ( 6 , 36 , 37 ).…”

Section: Resultsmentioning

confidence: 99%

Fully resorbable poly-4-hydroxybutyrate (P4HB) mesh for soft tissue repair and reconstruction: A scoping review

et al. 2023

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BackgroundPoly-4-hydroxybutyrate (P4HB) is a fully resorbable, biologically-produced polymer with a strength and flexibility comparable to permanent synthetic polymers. The objective was to identify/summarize all peer-reviewed publications involving P4HB mesh.MethodsA scoping review was conducted within PubMed and included articles published through October 2022.ResultsA total of n = 79 studies were identified (n = 12 in vitro/bench; n = 14 preclinical; n = 6 commentaries; n = 50 clinical). Of the clinical studies, n = 40 reported results applicable to hernia and n = 10 to plastic/reconstructive surgery and involved patients of all Centers for Disease Control (CDC) wound classes and Ventral Hernia Working Group (VHWG) grades.ConclusionP4HB mesh provides long-term hernia repair strength and exhibits promising clinical outcomes beyond its resorption period. Future studies should include randomized controlled trials comparing P4HB to other biomaterials, as well as optimal patient selection, operative technique, long-term outcomes, minimization of potential mesh-related complications, and potential contraindications/complications for P4HB in hernia/abdominal wall reconstruction.

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“…Although the use of mesh greatly reduces the recurrence rate of incisional hernia and promotes wound healing, according to a large number of clinical data feedback, the polyester mesh is rarely used due to poor anti-infection ability and heavy foreign body reaction. The polypropylene mesh has good histocompatibility, light inflammatory response, and strong anti-infection ability, but it is easy to adhere to viscera, resulting in intestinal obstruction, intestinal leakage, and other complications ( Aydemir Sezer et al, 2019 ; Yang et al, 2020b ; Nessel et al, 2021 ; Pascual et al, 2022 ). Expanded polytetrafluoroethylene (ePTFE) is not easy to adhere to viscera, but it has poor anti-infection ability and poor firmness.…”

Section: Introductionmentioning

confidence: 99%

“…The polypropylene mesh has good histocompatibility, light inflammatory response, and strong anti-infection ability, but it is easy to adhere to viscera, resulting in intestinal obstruction, intestinal leakage, and other complications (Aydemir Sezer et al, 2019;Yang et al, 2020b;Nessel et al, 2021;Pascual et al, 2022). Expanded polytetrafluoroethylene (ePTFE) is not easy to adhere to viscera, but it has poor anti-infection ability and poor firmness.…”

Section: Introductionmentioning

confidence: 99%

Construction and properties of the silk fibroin and polypropylene composite biological mesh for abdominal incisional hernia repair

Luan

Cao

et al. 2022

Front. Bioeng. Biotechnol.

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Background: In this study, a new composite biological mesh named SFP was prepared by combining silk fibroin with polypropylene mesh. The mechanism and clinical application value of the SFP composite mesh were explored.Methods: The fibrous membrane was prepared by electrospinning of silk fibroin. The silk fibrous membrane was adhered to the polypropylene mesh by fibrin hydrogel to make a new composite mesh. The characterizations were verified by structural analysis and in vitro cell experiments. A total of 40 Sprague–Dawley rats were randomly divided into two groups, and 20 rats in each group were implanted with the SFP mesh and pure polypropylene mesh, respectively. The rats were sacrificed in batches on the 3rd, 7th, 14th, and 90th days after surgery. The adhesion degree and adhesion area on the mesh surface were compared, and a histopathological examination was carried out.Results:In vitro cell function experiments confirmed that the SFP mesh had good cell viability. The control group had different degrees of adhesion on the 3rd, 7th, 14th, and 90th days after surgery. However, there was almost no intraperitoneal adhesions on the 3rd and 7th days after surgery, and some rats only had mild adhesions on the 14th and 90th days after surgery in the SFP group. There were statistically significant differences in the postoperative intraperitoneal adhesion area and adhesion degree between the two groups (p < 0.05). Histopathological examination confirmed that the mesenchymal cells were well arranged and continuous, and there were more new capillaries and adipocyte proliferation under the mesenchymal cells in the SFP group.Conclusion: The SFP mesh shows good biocompatibility and biofunction in vitro and in vivo. It can promote the growth of peritoneal mesenchymal cells. The formation of a new mesenchymal cell layer can effectively reduce the extent and scope of adhesion between the mesh and abdominal organs. The SFP mesh will have a good application prospect in the field of abdominal wall hernia repair.

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Behaviour at the peritoneal interface of next-generation prosthetic materials for hernia repair

Cited by 5 publications

References 43 publications

Abdominal Wall Reconstruction in a Terminal-Stage Peritoneal Cancer Patient after Emergency Debulking Procedure: A Case Report

Abdominal Wall Reconstruction in a Terminal-Stage Peritoneal Cancer Patient after Emergency Debulking Procedure: A Case Report

Fully resorbable poly-4-hydroxybutyrate (P4HB) mesh for soft tissue repair and reconstruction: A scoping review

Construction and properties of the silk fibroin and polypropylene composite biological mesh for abdominal incisional hernia repair

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