Behaviour and Personality in Childhood as Predictors of Adult Psychiatric Disorder

Rodgers, Bryan

doi:10.1111/j.1469-7610.1990.tb01577.x

Cited by 92 publications

(60 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, results from a longitudinal study of a British birth cohort suggest that neuroticism is unrelated to participation, while having a psychiatric disorder predicted a slightly higher participation rate. 15 The frequency of short alleles in the present study was very close to that reported by Lesch et al (43.5% vs 43%) in a predominantly Caucasian sample, 1 but much lower than the frequency in Japanese samples (77% and 83.3%), 4,6 and slightly lower than an Israeli sample (53%). 3 There appear to be major ethnic differences which are a potential confounding factor in association studies of the 5-HTTLPR.…”

supporting

confidence: 72%

An association study of a functional polymorphism of the serotonin transporter gene with personality and psychiatric symptoms

et al. 1998

View full text Add to dashboard Cite

A functional polymorphism in the regulatory region of the serotonin transporter gene has been reported to be associated with anxiety-related personality traits. 1 We attempted to replicate this finding in an association study involving 759 Caucasians selected from the general Australian population. We found no associations with personality traits (including neuroticism, negative affect and behavioral inhibition), anxiety and depressive symptoms, or alcohol misuse.The human serotonin transporter (5-HTT) gene has a functional polymorphism in its regulatory region which Lesch et al 1 found to be associated with anxietyrelated personality traits. Individuals with a short allele in the 5-HTT gene-linked polymorphic region (5-HTTLPR) scored higher on neuroticism, anxiety and harm avoidance than those who were homozygous for the long allele. The association was found in both population and sib-pair samples which were predominantly Caucasian. Subsequent studies have not been able to replicate these results. Several studies have failed to find associations of the 5-HTTLPR with neuroticism and harm avoidance. [2][3][4] Association studies with psychiatric disorders have also generally been negative, including studies on panic disorder, 5-7 unipolar and bipolar affective disorder 8 and anorexia. 9 However, a study of unipolar and bipolar affective disorder in three centres did find an association with the short allele in the combined data from the centres, even though the associations were not statistically significant in the individual centres. 10 Associations have also been reported between the short allele of the 5-HTTLPR and severe alcohol dependence 11 and late-onset Alzheimer's disease. 12 A limitation of the negative studies is that their sample size is smaller than the original study of Lesch et al, 1 which leaves open the possibility of lack of statistical power. Here we report data from a population sample of 759 Caucasians which is larger than any study so far. The study includes measures of anxiety-related personality traits (neuroticism, negative affect, behavioral inhibition), anxiety and depressive symptoms, and a measure of alcohol misuse.The allele frequencies were 56.5% for the long allele and 43.5% for the short. The genotype frequencies were: long/long 33.5%, long/short 46.1%, and short/short 20.4%. Table 1 shows the mean scores on the personality and psychiatric symptom measures. For most scales, the numbers of subjects were slightly smaller than indicated in the table because of missing data. There were no significant differences at the P Ͻ 0.05 level on any measure when the data were analyzed by genotype. Similarly, there were no significant differences when short/short and long/short individuals were combined into one group and contrasted with the long/long group. There were also no significant differences between genotypes in age, sex, education or occupational status, so it was not necessary to adjust for these as covariates in the analysis.A check was also made for interaction effects involving t...

show abstract

supporting

confidence: 72%

An association study of a functional polymorphism of the serotonin transporter gene with personality and psychiatric symptoms

et al. 1998

View full text Add to dashboard Cite

show abstract

“…Pathways from childhood to adult life As at age 36, measures of adolescent behaviour mediated some of the effect of family background (Rodgers, 1990b). In particular, the effect of maternal neuroticism on the symptom score was reduced to nonsignificance.…”

Section: Adult Health and Social Circumstancesmentioning

confidence: 99%

“…Earlier research on this cohort demonstrated a link between adult affective disorder (as measured by the Present State Examination) at 36 years and measures of the early environment (Rodgers, 1990a) and childhood behaviour and temperament (Rodgers, 1990b). Measures of early behaviour were more strongly associated with adult symptoms than the environmental measures and suggested that childhood and adolescent behaviour and personality mediated the long term effects of the early environment.…”

Section: Introductionmentioning

confidence: 99%

“…Adolescent behavioural measures examined, detailed previously (Rodgers, 1990b) included two scales (range 13-32) based on teachers' reports of antisocial or anxious behaviours at the age of 15 years, and the neuroticism and extraversion scales (range 0-12) of the short Maudsley Personality Inventory (Eysenck, 1958) based on study members' responses at age 16 years. Early cognitive ability, previously found to be associated with affective disorders in this study (van Os, Jones, Wadsworth, & Murray, 1997), was taken as the average standardised score on verbal and non verbal tests taken at 15 years (Richards, Kuh, Hardy, & Wadsworth, 1999).…”

Section: Characteristics Of the Childmentioning

confidence: 99%

See 1 more Smart Citation

Lifetime risk factors for women's psychological distress in midlife

Kuh

Hardy

Rodgers

et al. 2002

Social Science & Medicine

Self Cite

View full text Add to dashboard Cite

“…Nevertheless, it seems that the obtained figures are similar in developed countries. The rate of behavioral problems varies with the age of the children (11). The results of a study showed that the rate of aggression varied from 9-10% (12).…”

Section: Discussionmentioning

confidence: 99%

Types of Aggression Among Kindergarten and Preschool Children of Mohr County/Fars Province in 2013–2014

Yektatalab¹,

Alipour²,

Edraki³

et al. 2015

Int J School Health

View full text Add to dashboard Cite

Background: Aggression in childhood is the predictor of delinquency, depression, school dropout, and drug abuse in higher ages. The preschool year is an appropriate time to diagnose children's problems and plan for interventions to prevent their emotional, social, and educational problems. Objectives: The present study determines the types of aggression among kindergarten and preschool children. Patients and Methods: A total of 14 kindergarten and preschool centers were chosen using random cluster sampling in Mohr County 2013. The inclusion criteria were level of aggression higher than 125.77 for boys and 117.48 for girls based on the preschooler aggression inventory. In this regard, 60 kindergarten and preschool children were enrolled in this study. Results:The results showed that 33.45%, 31.15%, 22.29%, and 13.11% of the children had verbal aggression, physical aggression, relational aggression, and impulsive anger, respectively. In addition, the verbal aggression and physical aggression scores of the boys were higher than for girls. However, no significant differences were found between the genders concerning relational aggression and impulsive anger. Moreover, the highest level of aggression was observed among 6 years old children followed by 5-, 3-, and 4-years old children. Conclusions: Considering the high rate of verbal and physical aggression and the negative effects of aggression on educational and social behavior, early intervention is recommended for prevention and treatment.

show abstract

Behaviour and Personality in Childhood as Predictors of Adult Psychiatric Disorder

Cited by 92 publications

References 43 publications

An association study of a functional polymorphism of the serotonin transporter gene with personality and psychiatric symptoms

An association study of a functional polymorphism of the serotonin transporter gene with personality and psychiatric symptoms

Lifetime risk factors for women's psychological distress in midlife

Types of Aggression Among Kindergarten and Preschool Children of Mohr County/Fars Province in 2013–2014

Contact Info

Product

Resources

About