Behaviour and Monoamine Levels During Long‐Term Administration of Reserpine to Rabbits

Häggendal, Jan; Lindqvist, Margit

doi:10.1111/j.1748-1716.1963.tb02605.x

Cited by 62 publications

(20 citation statements)

References 8 publications

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“…In this regard, the gradual neuronal sprouting could account for the apparent recovery of VMAT2 that has been observed in primates 1.5 years after brief exposure to METH (2 Â 2 mg/kg, 6 h apart) (Harvey et al, 2000). It is important to note, however, that while the VMAT2 marker has been considered by many to be an index of DA terminal integrity, it is also possible that some METH effects on this transporter reflect selective damage to the vesicle in the absence of terminal degeneration, as is evident following reserpine administration, which would then require synthesis and axonal transport of new vesicles for eventual full recovery of vesicular-dependent functions (Häggendal and Lindqvist, 1964). Furthermore, recent evidence suggests relatively rapid METH-induced changes in the subcellular distribution of VMAT2 (as well as DAT) (Riddle et al, 2002b;Sandoval et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Escalating Dose Methamphetamine Pretreatment Alters the Behavioral and Neurochemical Profiles Associated with Exposure to a High-Dose Methamphetamine Binge

Segal

Kuczenski

O'Neil

et al. 2003

Neuropsychopharmacol

105

108

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The neurotoxic effects of methamphetamine (METH) have been characterized primarily from the study of high-dose binge regimens in rodents. However, this drug administration paradigm does not include a potentially important feature of stimulant abuse in humans, that is, the gradual escalation of stimulant doses that frequently occurs prior to high-dose exposure. We have argued that pretreatment with escalating doses (EDs) might significantly alter the neurotoxic profile produced by a single high-dose binge. In the present study, we tested this hypothesis by pretreating rats with saline or gradually increasing doses of METH (0.1-4.0 mg/kg over 14 days), prior to an acute METH binge (4 Â 6 mg/kg at 2 h intervals). These animals, whose behavior was continuously monitored throughout drug treatment, were then killed 3 days later for determination of caudate-putamen dopamine (DA) content, levels of [ We suggest that further study of the effects produced by a regimen which includes a gradual escalation of doses prior to high-dose METH binge exposure could more accurately identify the neurochemical and behavioral changes relevant to those that occur as a consequence of high-dose METH abuse in humans.

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Section: Discussionmentioning

confidence: 99%

Escalating Dose Methamphetamine Pretreatment Alters the Behavioral and Neurochemical Profiles Associated with Exposure to a High-Dose Methamphetamine Binge

Segal

Kuczenski

O'Neil

et al. 2003

Neuropsychopharmacol

105

108

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“…Die in der Tabelle angegebenen Zahlen stellen die tatsächlich gemessenen, nicht korrigierten Werte dar. [10,11,17). Im letzteren Fall wurde dieses Verhalten auf eine relativ schnellere Auffüllung desjenigen NA-Anteils (Speichers), der in freier, funktionell aktiver Form vorliegt, zurückgeführt.…”

Section: Extraktion Und Bestimmung Der Katecholamineunclassified

Beeinflussung der Gehirn-Katecholamine, der Spontanaktivität und der L-DOPA-Hyperaktivität durch Diäthyldithiocarbamat

Aigner¹,

Hornykiewicz²,

Lisch³

et al. 1967

Pharmacology

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“…This concept of two pools of catecholamines in the nerve ending has been proposed by several workers (Haggendal & Lindqvist, 1963Weissmann, Koe & Tenen, 1966;Haggendal, Lindqvist & Roos, 1967;Rech, Carr & Moore, 1968).…”

Section: Introductionmentioning

confidence: 99%

Importance of noradrenaline found in a functional pool in maintaining spontaneous locomotor activity in rats

Onn-Leng

Webster

1971

British J Pharmacology

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Summary1. Spontaneous locomotor activity (activity) in male Wistar rats was compared with the concentrations of brain noradrenaline (NA), dopamine (DA) and metaraminol. 2. a-Methyl-m-tyrosine (aMMT) (400 mg/kg) reduced the concentrations of DA as well as NA but activity remained high in the presence of metaraminol formed from the aMMT. When tetrabenazine (TBZ) was given after aMMT pretreatment there was a fall in the levels of activity and in the concentrations of NA, DA and metaraminol.3. a-Methyl-p-tyrosine (aMT) produced a fall in activity which was correlated with falls in the concentrations of NA and DA. 5-Hydroxytryptamine (5-HT) did not appear to be affected. 4. After depletion of NA and DA by aMT and TBZ, administration of L-dopa produced a return in activity which was significantly correlated with the concentration of NA but not DA. When aMMT was given to a similar group of pretreated animals there was no recovery of activity despite high concentrations of DA and metaraminol.5. The dopamine 13 hydroxylase inhibitor, diethyldithiocarbamate (DDC), suppressed activity as well as the concentrations of NA and DA at high doses (750 mg/kg) but smaller doses (400 mg/kg) plus L-dopa gave high DA concentrations without activity. 6. It is concluded that NA and not DA is associated with activity but that it is only part of the total NA which is in the biosynthetic storage granule affected by drugs like aMT and TBZ, which controls activity. Drugs that do not affect this pool may lower NA concentrations but not reduce activity. 7. The replacement of NA by metaraminol in this functional pool does not restore activity. IntroductionOur investigations (Chan & Webster, 1971) have suggested that the method by which a drug depletes the central nervous system of catecholamines may determine whether or not it reduces activity. Thus, although both a-methyl-m-tyrosine and tetrabenazine caused a comparable depletion of brain noradrenaline in the rat, at

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Behaviour and Monoamine Levels During Long‐Term Administration of Reserpine to Rabbits

Cited by 62 publications

References 8 publications

Escalating Dose Methamphetamine Pretreatment Alters the Behavioral and Neurochemical Profiles Associated with Exposure to a High-Dose Methamphetamine Binge

Escalating Dose Methamphetamine Pretreatment Alters the Behavioral and Neurochemical Profiles Associated with Exposure to a High-Dose Methamphetamine Binge

Beeinflussung der Gehirn-Katecholamine, der Spontanaktivität und der L-DOPA-Hyperaktivität durch Diäthyldithiocarbamat

Importance of noradrenaline found in a functional pool in maintaining spontaneous locomotor activity in rats

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