Behavioral Switch of Food Preference upon Sugar Deficiency Is Regulated by GPCRs in Drosophila

Liu, Chang; Bai, Xiaobing; Sun, Jinsheng; Zhang, Xiaofan; Li, Yan

doi:10.1016/j.jgg.2015.05.004

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…Mth is a member of the secretin-incretin receptor subfamily, belonging to the G protein-coupled receptor family. In our previous behavioural screen for G protein-coupled receptors required for PIFI in adult flies, one of the chosen candidates belongs to the same subfamily43. The identification of the FIT receptor, together with physiological studies of FIT targeting neurons in the PI brain region will enable us to better understand how AA state signals are coded, processed and integrated with signals from other nutrients, and how these nutrition signals ultimately contribute to an appropriate feeding decision, both in lower and higher organisms.…”

Section: Discussionmentioning

confidence: 99%

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Drosophila FIT is a protein-specific satiety hormone essential for feeding control

et al. 2017

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Protein homeostasis is critical for health and lifespan of animals. However, the mechanisms for controlling protein feeding remain poorly understood. Here we report that in Drosophila, protein intake-induced feeding inhibition (PIFI) is specific to protein-containing food, and this effect is mediated by a fat body (FB) peptide named female-specific independent of transformer (FIT). Upon consumption of protein food, FIT expression is greatly elevated. Secreted FIT peptide in the fly haemolymph conveys this metabolic message to the brain, thereby promoting the release of Drosophila insulin-like peptide 2 (DILP2) and suppressing further protein intake. Interestingly, Fit is a sexually dimorphic gene, and consequently protein consumption-induced insulin release, as well as protein feeding behaviour, are also dimorphic between sexes. Thus, our findings reveal a protein-specific satiety hormone, providing important insights into the complex regulation of feeding decision, as well as the sexual dimorphism in feeding behaviour.

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Section: Discussionmentioning

confidence: 99%

“…A two-choice feeding assay was adapted and modified from the classic two-choice feeding assay14 and described in our previous report43. In brief, 30 flies were allowed to choose between two types of coloured foods for 30 min in the darkness, and then were sorted according to the colour in their abdomens.…”

Section: Methodsmentioning

confidence: 99%

Drosophila FIT is a protein-specific satiety hormone essential for feeding control

et al. 2017

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Fruit fly research in China

Cheng

Chen

2018

Journal of Genetics and Genomics

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Using Pox-Neuro (Poxn) Mutants in Drosophila Gustation Research: A Double-Edged Sword

Chen

Park

et al. 2018

Front. Cell. Neurosci.

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In Drosophila, Pox-neuro (Poxn) is a member of the Paired box (Pax) gene family that encodes transcription factors with characteristic paired DNA-binding domains. During embryonic development, Poxn is expressed in sensory organ precursor (SOP) cells of poly-innervated external sensory (p-es) organs and is important for specifying p-es organ identity (chemosensory) as opposed to mono-innervated external sensory (m-es) organs (mechanosensory). In Poxn mutants, there is a transformation of chemosensory bristles into mechanosensory bristles. As a result, these mutants have often been considered to be entirely taste-blind, and researchers have used them in this capacity to investigate physiological and behavioral functions that act in a taste-independent manner. However, recent studies show that only external taste bristles are transformed in Poxn mutants whereas all internal pharyngeal taste neurons remain intact, raising concerns about interpretations of experimental results using Poxn mutants as taste-blind flies. In this review, we summarize the value of Poxn mutants in advancing our knowledge of taste-enriched genes and feeding behaviors, and encourage revisiting some of the conclusions about taste-independent nutrient-sensing mechanisms derived from these mutants. Lastly, we highlight that Poxn mutant flies remain a valuable tool for probing the function of the relatively understudied pharyngeal taste neurons in sensing meal properties and regulating feeding behaviors.

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Behavioral Switch of Food Preference upon Sugar Deficiency Is Regulated by GPCRs in Drosophila

Cited by 3 publications

References 19 publications

Drosophila FIT is a protein-specific satiety hormone essential for feeding control

Drosophila FIT is a protein-specific satiety hormone essential for feeding control

Fruit fly research in China

Using Pox-Neuro (Poxn) Mutants in Drosophila Gustation Research: A Double-Edged Sword

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