Behavioral Study of Calorie-restricted Rats from Early Old Age

Geng, Yiqun; Guan, Jitian; Xu, Ming; Fu, Yucai

doi:10.1109/iembs.2007.4352809

Cited by 13 publications

(15 citation statements)

References 12 publications

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“…For example, Means et al reported that 40% CR begun at 14-mo in C57BL/6Nnia mice attenuated age-related decline in grip strength, motor coordination, and spontaneous alternation behavior, but did not have significant effects on performance in the Morris water maze (MWM) (Means et al, 1993). Geng et al noted significant benefits to motor performance (open field) and cognition (MWM) as well as for survival in 18-mo old rats introduced to 40% CR for 6 months (Geng et al, 2007). Singh et al introduced an IF regimen (EOD) to 21-mo old male Wistar rats for 3 months and noted significant improvements in motor performance (rotarod test) and cognition (MWM) (Singh et al, 2012).…”

Section: At What Age Does Cr No Longer Produce Benefits?mentioning

confidence: 99%

“…Kuhla et al reported improved learning and memory performance of 19-mo old mice begun on a regimen of 40% CR at weaning (Kuhla et al, 2013). Geng et al initiated 40% CR in 18-mo old rats and noted improved learning and memory in MWM performance at 24 mo (Geng et al, 2007). Similarly, Singh et al subjected 24-mo old male Wistar rats to EOD feeding for 3 mo and reported improved MWM in both the learning and memory phases of the task (Singh et al, 2012).…”

Section: Does Cr Attenuate Cognitive Decline?mentioning

confidence: 99%

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Calorie restriction in rodents: Caveats to consider

Ingram

Cabo

2017

Ageing Research Reviews

107

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The calorie restriction paradigm has provided one of the most widely used and most useful tools for investigating mechanisms of aging and longevity. By far, rodent models have been employed most often in these endeavors. Over decades of investigation, claims have been made that the paradigm produces the most robust demonstration that aging is malleable. In the current review of the rodent literature, we present arguments that question the robustness of the paradigm to increase lifespan and healthspan. Specifically, there are several questions to consider as follows: (1) At what age does CR no longer produce benefits? (2) Does CR attenuate cognitive decline? (3) Are there negative effects of CR, including effects on bone health, wound healing, and response to infection? (4) How important is schedule of feeding? (5) How long does CR need to be imposed to be effective? (6) How do genotype and gender influence CR? (7) What role does dietary composition play? Consideration of these questions produce many caveats that should guide future investigations to move the field forward.

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Section: At What Age Does Cr No Longer Produce Benefits?mentioning

confidence: 99%

Section: Does Cr Attenuate Cognitive Decline?mentioning

confidence: 99%

Calorie restriction in rodents: Caveats to consider

Ingram

Cabo

2017

Ageing Research Reviews

107

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“…Depending on the animal species examined, both decreases and increases in locomotor activity have been described in response to limited food supplies (Pirke et al, 1993;Weed et al, 1997;Geng et al, 2007;Teske and Kotz, 2009;Boehm et al, 2010;Gingerich et al, 2010;Yu et al, 2010). However, gait-specific effects have not been considered.…”

Section: Received 1 November 2013; Accepted 10 April 2014mentioning

confidence: 99%

“…In contrast, rats show hyperactive wheel running in response to starvation (Koubi et al, 1991;Pirke et al, 1993). Similarly, caloric restriction increases physical activity in rats (Geng et al, 2007;Teske and Kotz, 2009) and rhesus monkeys (Weed et al, 1997). It is of note that up to 80% of human patients with the eating disorder anorexia nervosa show excessive physical activity (Koubi et al, 1991;Hebebrand et al, 2003).…”

Section: Research Articlementioning

confidence: 99%

Gait-specific adaptation of locomotor activity in response to dietary restriction inCaenorhabditis elegans

Lüersen

Faust

Gottschling

et al. 2014

Journal of Experimental Biology

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Locomotion is crucial for the survival of living organisms, as it allows foraging, flight and mating behaviour. In response to environmental cues, many organisms switch between alternative forms of locomotion, referred to as gaits. The nematode Caenorhabditis elegans exhibits two gaits: swimming in liquids and crawling on dense gels. The kinematics and patterns of muscle activity differ between the two gaits, with swimming being less efficient than crawling. We found that C. elegans when grown on dietary restriction (DR) plates and then tested immediately for swimming activity exhibit an accelerated frequency of body-bending swimming compared with ad libitum-fed worms, resulting in an increased swimming speed. This response is independent of the presence or absence of food bacteria in the assay liquid. In contrast, the crawling speed of DR worms on assay agar plates is decreased and influenced by food availability. Because DR also attenuates the disturbed swimming activity of worms that are deficient in the presynaptic dopamine transporter DAT-1, our data link DR-induced alterations of the swimming gait to synaptic processes. This strongly suggests a biochemical rather than a biomechanical response to DR provoked by changes in the worm's body structure. We conclude that the increase in locomotor activity in response to DR is specific to the swimming gait and might represent a survival strategy, allowing food-deprived nematodes to exit unfavourable environments.

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“…It is common to restrict the consumption of food to motivate aged animals to look for the treats in the maze [221]. However, in the case of dietary interventions this may be a problem, especially because food restriction is reported to enhance spatial memory in aged rodents [72,166].…”

Section: Comparison Between the Radial Arm Maze And Morris Water Mazementioning

confidence: 99%

The impact of flavonoids on spatial memory in rodents: from behaviour to underlying hippocampal mechanisms

et al. 2009

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Emerging evidence suggests that a group of dietary-derived phytochemicals known as flavonoids are able to induce improvements in memory, learning and cognition. Flavonoids have been shown to modulate critical neuronal signalling pathways involved in processes of memory, and therefore are likely to affect synaptic plasticity and long-term potentiation mechanisms, widely considered to provide a basis for memory. Animal dietary supplementation studies have further shown that flavonoidrich foods are able to reverse age-related spatial memory and spatial learning impairments. A more accurate understanding of how a particular spatial memory task works and of which aspects of memory and learning can be assessed in each case, are necessary for a correct interpretation of data relating to diet-cognition experiments. Further understanding of how specific behavioural tasks relate to the functioning of hippocampal circuitry during learning processes might be also elucidative of the specific observed memory improvements. The overall goal of this review is to give an overview of how the hippocampal circuitry operates as a memory system during behavioural tasks, which we believe will provide a new insight into the underlying mechanisms of the action of flavonoids on cognition.

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Behavioral Study of Calorie-restricted Rats from Early Old Age

Abstract: These findings demonstrated that CR in early old rats delayed the declination of spatial cognition.

Cited by 13 publications

References 12 publications

Calorie restriction in rodents: Caveats to consider

Calorie restriction in rodents: Caveats to consider

Gait-specific adaptation of locomotor activity in response to dietary restriction inCaenorhabditis elegans

The impact of flavonoids on spatial memory in rodents: from behaviour to underlying hippocampal mechanisms

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