Behavioral, sleep-waking and EEG power spectral effects following the two specific 5-HT uptake inhibitors zimeldine and alaproclate in cats

Sommerfelt, Liv; Ursin, Reidun

doi:10.1016/s0166-4328(05)80076-2

Cited by 38 publications

(6 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Initiation and duration of REM sleep is modulated by the serotonergic system (Adrien, 2002 ;Portas et al, 1996). Increase in extracellular 5-HT concentration by 5-HT releasers, 5-HT reuptake blockers or several 5-HT receptor agonists may increase REM latency (Monti and Monti, 1999 ;Sommerfelt and Ursin, 1991 ;Ursin, 2002). Preclinical studies involving pharmacological depletion or anatomical lesions of 5-HT neurons have generally shown changes in REM and non-rapid eye movement (NREM) sleep.…”

Section: 'Ecstasy 'mentioning

confidence: 99%

Decrease in REM latency and changes in sleep quality parallel serotonergic damage and recovery after MDMA: a longitudinal study over 180 days

Kirilly

Molnár

Balogh

et al. 2008

Int. J. Neuropsychopharm.

View full text Add to dashboard Cite

The recreational drug ecstasy [3,4-methylenedioxymethamphetamine (MDMA)], has been found to selectively damage brain serotonin neurons in experimental animals, and probably in human MDMA users, but detailed morphometric analyses and parallel functional measures during damage and recovery are missing. Since there is evidence that serotonin regulates sleep, we have compared serotonergic markers parallel with detailed analysis of sleep patterns at three time-points within 180 d after a single dose of 15 mg/kg MDMA in male Dark Agouti rats. At 7 d and 21 d after MDMA treatment, significant(30-40%), widespread reductions in serotonin transporter (5-HTT) density were detected in the cerebral cortex, hippocampus, most parts of the hypothalamus, and some of the brainstem nuclei. With the exception of the hippocampus, general recovery was observed in the brain 180 d after treatment. Transient increases followed by decreases were detected in 5-HTT mRNA expression of dorsal and median raphe nuclei at 7 d and 21 d after the treatment. Significant reductions in rapid eye movement (REM) sleep latency, increases in delta power spectra in non-rapid eye movement sleep and increased fragmentation of sleep were also detected, but all these alterations disappeared by the 180th day. The present data provide evidence for long-term, albeit, except for the hippocampus, transient changes in the terminal and cellular regions of the serotonergic system after this drug. Reduced REM latency and increased sleep fragmentation are the most characteristic alterations of sleep consistently described in depression using EEG sleep polygraphy.

show abstract

Section: 'Ecstasy 'mentioning

confidence: 99%

Decrease in REM latency and changes in sleep quality parallel serotonergic damage and recovery after MDMA: a longitudinal study over 180 days

Kirilly

Molnár

Balogh

et al. 2008

Int. J. Neuropsychopharm.

View full text Add to dashboard Cite

show abstract

“…Dopaminergic VTA neurons have a crucial role in wake maintenance in the face of various motivational processes, including mate- and food-seeking and predator evading 31 . Serotonergic DRN neurons have been suggested to support quiet wakefulness, possibly preceding sleep initiation 51, 102, 103 . A distinct role for each wake-related neuronal population in promoting distinct forms of arousal under specific environmental conditions could clarify the relatively surprising redundancy in wake-promoting circuits 13, 51 .…”

Section: Maintenance Of Vigilance Statesmentioning

confidence: 99%

Neuronal substrates for initiation, maintenance, and structural organization of sleep/wake states

Eban-Rothschild

Lecea

2017

F1000Res

View full text Add to dashboard Cite

Animals continuously alternate between sleep and wake states throughout their life. The daily organization of sleep and wakefulness is orchestrated by circadian, homeostatic, and motivational processes. Over the last decades, much progress has been made toward determining the neuronal populations involved in sleep/wake regulation. Here, we will discuss how the application of advanced in vivo tools for cell type–specific manipulations now permits the functional interrogation of different features of sleep/wake state regulation: initiation, maintenance, and structural organization. We will specifically focus on recent studies examining the roles of wake-promoting neuronal populations.

show abstract

“…One of the most consistent effects of pharmacological action on sleep architecture has been the robust and immediate suppression of REM sleep caused by administration of many antidepressant drugs, both in animals (monkey, Crofts et al, 1998; rat, Ivarsson et al, 2005; mouse, Monaca et al, 2003; cat, Sommerfelt and Ursin, 1991) and in healthy volunteers and depressed patients (Wilson and Argyropoulos, 2005). The effects are dose-related and consist of reduction in the overall amount of REM sleep during the sleep period, and delay of the first entry into REM sleep (increased ROL).…”

Section: Using Sleep To Measure Serotonergic Effect In the Brainmentioning

confidence: 99%

Sleep and its disorders in translational medicine

2011

View full text Add to dashboard Cite

The study of sleep is a useful approach to studying the brain in psychiatric disorders and in investigating the effects of psychotropic drugs. Sleep physiology lends itself well to pharmacological and physiological manipulation, as it has the advantage of a functional output, the electroencephalograph, which is common to all mammals, and can be measured in freely moving (or naturally sleeping) animals under controlled laboratory conditions or in a naturalistic home environment. The complexity of sleep architecture varies between species but all share features which are comparable. In addition, sleep architecture is sensitive to changes in brain neurotransmitters such as serotonin, so cross-species sleep measurement can be combined with pharmacological manipulation to investigate the receptor mechanisms controlling sleep-wake regulation and sleep architecture in response to known and novel agents. Translational approaches such as these have improved our understanding of sleep circuitry and facilitated the development of new treatments for sleep disorders, particularly insomnia. This review provides examples of how research findings within the sleep field have been translated between animal models, healthy volunteers and patient populations with particular focus on the serotonergic system.

show abstract

Behavioral, sleep-waking and EEG power spectral effects following the two specific 5-HT uptake inhibitors zimeldine and alaproclate in cats

Cited by 38 publications

References 34 publications

Decrease in REM latency and changes in sleep quality parallel serotonergic damage and recovery after MDMA: a longitudinal study over 180 days

Decrease in REM latency and changes in sleep quality parallel serotonergic damage and recovery after MDMA: a longitudinal study over 180 days

Neuronal substrates for initiation, maintenance, and structural organization of sleep/wake states

Sleep and its disorders in translational medicine

Contact Info

Product

Resources

About