Behavioral sensitization to methamphetamine in the rat: an ontogenic study

Fujiwara, Yutaka; Kazahaya, Yasuko; Nakashima, Makoto; Satō, Masaki; Otsuki, Saburo

doi:10.1007/bf00518183

Cited by 73 publications

(43 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been shown that this sensitisation response does not occur until 3 -4 weeks of age. The authors suggested that the appearance of mature presynaptic dopamine autoreceptors may be necessary for sensitisation (Fujiwara et al 1987) or that maturation of dopamine reuptake sites is the limiting factor in the development of sensitisation (Fujiwara et al 1987). Nevertheless, these findings related to the age of experimental animals are not in contradiction to our studies, as the age of the rats used for our purposes was about seven weeks at the beginning of each experiment.…”

Section: Discussioncontrasting

confidence: 60%

“…Other authors make an attempt to evaluate the age-related differences in amphetamine and methamphetamine sensitization (Fujiwara et al 1987;Kolta et al 1990), noting that adult rats pre-treated with amphetamines display an augmentation of locomotor response when subsequently given an amphetamine "challenge dose". It has been shown that this sensitisation response does not occur until 3 -4 weeks of age.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of Cannabinoid Receptor Ligands on Sensitisation to Methamphetamine Effects on Rat Locomotor Behaviour

2008

View full text Add to dashboard Cite

Landa L., K Šlais, A. Šulcová: Impact of Cannabinoid Receptor Ligands on Sensitisation to Methamphetamine Effects on Rat Locomotor Behaviour. Acta Vet Brno 2008, 77: 183-191.The repeated administration of various drugs of abuse may lead to a gradually increased behavioural response to these substances, particularly an increase in locomotion and stereotypies may occur. This phenomenon is well known and described as behavioural sensitisation. An increased response to the drug tested, elicited by previous repeated administration of another drug is recognised as cross-sensitisation. Based on our earlier experiences with studies on mice, which confirmed sensitisation to methamphetamine and described cross-sensitisation to methamphetamine after pre-treatment with cannabinoid CB 1 receptor agonist, we focused the present study on the use of another typical laboratory animal -the rat. A biological validity of the sensitisation phenomenon was expected to be enhanced if the results of both mouse and rat studies were conformable. Similar investigation in rats brought very similar results to those described earlier in mice. However, at least some interspecies differences were noted in the rat susceptibility to the development of sensitisation to methamphetamine effects. Comparing to mice, it was more demanding to titrate a dose of methamphetamine producing behavioural sensitisation. Furthermore, we were not able to provoke cross-sensitisation by repeated administration of cannabinoid CB 1 receptor agonist methanandamide and similarly, we did not demonstrate the suppression of cross-sensitisation in rats that were repeatedly given combined pre-treatment with cannabinoid CB 1 receptor antagonist AM 251 and methamphetamine. Finally, unlike mice, an alternative behavioural change was registered after repeated methamphetamine treatment instead: the occurrence of stereotypic behaviour (nose rubbing).

show abstract

Section: Discussioncontrasting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Impact of Cannabinoid Receptor Ligands on Sensitisation to Methamphetamine Effects on Rat Locomotor Behaviour

2008

View full text Add to dashboard Cite

show abstract

“…Moreover, the definition of adolescent rats varies among the different published reports. Based on the papers that used rats of different ages and correlated their ages to that of humans [5,7,10,12,15,17,18,31,36,45,48,57,62], we made the following determination:…”

Section: Discussionmentioning

confidence: 99%

Acute and chronic methylphenidate dose–response assessment on three adolescent male rat strains

Peng¹,

Swann²,

Dafny³

2006

Brain Research Bulletin

View full text Add to dashboard Cite

Methylphenidate (MPD), commonly known as Ritalin, is the most frequently prescribed drug to treat children and adults with attention deficit hyperactivity disorder (ADHD). Adolescence is a period of development involving numerous neuroplasticities throughout the central nervous system (CNS). Exposure to a psychostimulant such as MPD during this crucial period of neurodevelopment may cause transient or permanent changes in the CNS. Genetic variability may also influence these differences. Thus, the objective of the present study was to determine whether acute and chronic administration of MPD (0.6, 2.5, or 10.0 mg/kg, i.p.) elicit effects among adolescent WKY, SHR, and SD rats and to compare whether there were strain differences. An automated, computerized, open-field activity monitoring system was used to study the dose response characteristics of acute and repeated MPD administration throughout the 11-day experimental protocol. Results showed that all three adolescent rat groups exhibited dose-response characteristics following acute and chronic MPD administration, as well as strain differences. These strain differences depended on the MPD dose and locomotor index. Chronic treatment of MPD in these animals did not elicit behavioral sensitization, a phenomenon described in adult rats that is characterized by the progressive augmentation of the locomotor response to repeated administration of the drug. These results suggest that the animal's age at time of drug treatment and strain/genetic variability play a crucial role in the acute and chronic effect of MPD and in the development of behavioral sensitization.

show abstract

“…The fact that dopamine agonists cause a robust and long-lasting hyperlocomotion or stereotypy sensitization after a critical period around postnatal week 3 in rodents [14][15][16] suggests that maturation of the specific neuronal systems could be required for the neuroadaptive phenomenon. The plausible development of functions or information processing in brain neuron circuits appears to be reflected in the results that the distribution of the brain c-Fos expression, which is a marker of neural activity, 17 following methamphetamine (MAP) or cocaine administration, changed markedly during postnatal development.…”

Section: Introductionmentioning

confidence: 99%

A developmentally regulated and psychostimulant-inducible novel rat gene mrt1 encoding PDZ-PX proteins isolated in the neocortex

et al. 2003

View full text Add to dashboard Cite

Single or repeated exposure to psychostimulants such as amphetamines and cocaine after postnatal week 3 leads to an enduring enhancement in the psychotomimetic responses elicited by a subsequent challenge of a stimulant in rodents. This behavioral sensitization phenomenon has been considered to be the neural consequences of stimulant-induced alterations in gene expression in the brain after a critical period of postnatal development. Using a differential cloning technique, RNA arbitrarily primed PCR, we have now identified from the rat neocortex a novel and developmentally regulated methamphetamine (MAP)-inducible gene mrt1 (MAP responsive transcript 1). mrt1 encodes two major types of PDZ-and PX-domains containing proteins of approximately 62 kDa in size with different carboxy termini, Mrt1a and Mrt1b. The mrt1 mRNAs for Mrt1a, mrt1a, and for Mrt1b, mrt1b, are predominantly expressed in various brain regions and the testes, respectively. Acute MAP injection upregulated mrt1b expression in the neocortex after postnatal week 3 in a D1 receptor antagonist-sensitive manner without affecting mrt1a expression. This upregulation was mimicked by another stimulant, cocaine, whereas pentobarbital and D1 antagonist failed to change the mrt1b transcript levels. Moreover, repeated daily treatment of MAP, but not MAP plus D1 antagonist, for 5 days caused an augmentation of the basal expression of mrt1b 2 and 3 weeks after the drug discontinuation. These late-developing, cocaine-crossreactive, D1 antagonist-sensitive and long-term regulations of mrt1b by MAP are similar to the pharmacological profiles of stimulant-induced behavioral sensitization, and therefore may be associated with the initiation and/or maintenance of the long-term neuronal adaptation.

show abstract

Behavioral sensitization to methamphetamine in the rat: an ontogenic study

Cited by 73 publications

References 8 publications

Impact of Cannabinoid Receptor Ligands on Sensitisation to Methamphetamine Effects on Rat Locomotor Behaviour

Impact of Cannabinoid Receptor Ligands on Sensitisation to Methamphetamine Effects on Rat Locomotor Behaviour

Acute and chronic methylphenidate dose–response assessment on three adolescent male rat strains

A developmentally regulated and psychostimulant-inducible novel rat gene mrt1 encoding PDZ-PX proteins isolated in the neocortex

Contact Info

Product

Resources

About