Behavioral sensitization and long-term neurochemical alterations associated with the fungicide triadimefon

Reeves, Ruth; Thiruchelvam, Mona; Richfield, Eric K.; Cory‐Slechta, Deborah A.

doi:10.1016/j.pbb.2003.08.003

Cited by 22 publications

(13 citation statements)

References 45 publications

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“…Signs of recovery were showed at day 5 after dosed. TF can produce hyperactivity in both mice and rats, repeated treatment with TF can lead to behavioral sensitization (Reeves et al, 2004(Reeves et al, , 2003, but those signs weren't observed in this study. No death occurred in all four groups.…”

Section: Preliminary Acute and Subacute Experimentscontrasting

confidence: 60%

Stereoselective metabolism, distribution, and bioaccumulation brof triadimefon and triadimenol in lizards

Wang

et al. 2014

Ecotoxicology and Environmental Safety

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a b s t r a c tIn this research, Chinese lizards (Eremias argus) were chosen as laboratory animal to evaluate the stereoselectivity in the processes of metabolism, distribution, and bioaccumulation of triadimefon. A validated chiral high-performance liquid chromatography coupled with triple quadruple mass spectrometry (HPLC-MS/MS) method was developed for determining enantiomers' residues of parent compound triadimefon and its metabolite triadimenol in lizard blood and tissues. Pharmacokinetic results of single-does exposure suggested that S-(þ )-triadimefon was metabolized easier than R-( À )-triadimefon, and RR-(þ )-triadimenol was the main metabolic product of triadimefon. During the continuous exposure of two dose (40 mg/kg bw Á d and 200 mg/kg bw Á d), enantiomers of triadimefon and triadimenol were detected in all body compartments, with the highest triadimefon concentrations in brain. However, the triadimenol concentrations were not significantly different among the compartments. The concentrations of RS-( þ)-triadimenol were negative correlated with concentrations of RR-(þ )-triadimenol both in blood (r¼ À0.775, p¼0.024) and liver (r¼ À0.834, p¼0.02) in 200 mg/kg bw Á d group, which indicates that chiral conversion between enantiomers of triadimenol might exist in the metabolic process of triadimefon. In all the processes, the enantiomer fractions (EFs) of R-(À )-triadimefon and RR-(þ )-triadimenol were significantly different from their natural ratios, 0.5 and 0.1, respectively, which proved that metabolism, bioaccumulation, and distribution of triadimefon and triadimenol in lizards were enantioselective. These results help enrich and supplement the knowledge of the stereoselective behaviour of triadimefon and triadimenol in reptile.

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Section: Preliminary Acute and Subacute Experimentscontrasting

confidence: 60%

Stereoselective metabolism, distribution, and bioaccumulation brof triadimefon and triadimenol in lizards

Wang

et al. 2014

Ecotoxicology and Environmental Safety

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“…Notably, memory impairment is unlikely to underlie these locomotor changes, since we show intact memory performance in the NOR task during METH abstinence. Increased psychostimulant-induced repetitive stereotypic/rearing behavior has been previously associated with psychotic properties of drugs of abuse (Reeves et al, 2003) and general psychotic symptoms in animals (see Forrest et al, 2014). Additionally, disruptions of pre-pulse inhibition were reported in mice following a similar administration/withdrawal paradigm used in the present study (7-day METH (1 mg/kg) administration and 7-day withdrawal; (Arai et al, 2008)).…”

supporting

confidence: 69%

Methamphetamine abstinence induces changes in μ-opioid receptor, oxytocin and CRF systems: Association with an anxiogenic phenotype

et al. 2016

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Methamphetamine abstinence induces changes in μ-opioid receptor, oxytocin and CRF systems: Association with an anxiogenic phenotype, Neuropharmacology (2016), doi: 10.1016/ j.neuropharm.2016.02.012. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…Behavioral studies after developmental exposure to environmental agents such as methylmercury (Rice, 1989), methylazoxymethanol (Lee and Rabe, 1992), and triethyltin (Barone et al, 1995) have provided evidence that latent neurotoxicity occurs in adult animals. More recently, developmental exposure to pesticides has been shown to result in a loss of nigral dopamine neurons and a decrease in dopamine content, 9 months later (Thiruchelvam et al, 2002;Reeves et al, 2003). These data suggest that behavioral and neurodegenerative outcomes later in life can be influenced by developmental exposure to environmental agents.…”

Section: Discussionmentioning

confidence: 90%

The Fetal Basis of Amyloidogenesis: Exposure to Lead and Latent Overexpression of Amyloid Precursor Protein and β-Amyloid in the Aging Brain

Basha¹,

Wei²,

Bakheet³

et al. 2005

J. Neurosci.

325

239

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The fetal basis of adult disease (FeBAD) hypothesis states that many adult diseases have a fetal origin. According to FeBAD, injury or environmental influences occurring at critical periods of organ development could result in "programmatic" changes via alterations in gene expression or gene imprinting that may result in functional deficits that become apparent later in life. Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized by excessive deposits of aggregated ␤-amyloid (A␤) peptides, which are snippets of the ␤-amyloid precursor protein (APP). The predominately sporadic nature of AD suggests that the environment must play a role in neurodegeneration. To examine latent responses to an environmental agent, we exposed rodents to lead and monitored the lifetime expression of the APP gene. We observed that APP mRNA expression was transiently induced in neonates, but exhibited a delayed overexpression 20 months after exposure to Pb had ceased. This upregulation in APP mRNA expression was commensurate with a rise in activity of the transcription factor Sp1, one of the regulators of the APP gene. Furthermore, the increase in APP gene expression in old age was accompanied by an elevation in APP and its amyloidogenic A␤ product. In contrast, APP expression, Sp1 activity, as well as APP and A␤ protein levels were unresponsive to Pb exposure during old age. These data suggested that environmental influences occurring during brain development predetermined the expression and regulation of APP later in life, potentially altering the course of amyloidogenesis.

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Behavioral sensitization and long-term neurochemical alterations associated with the fungicide triadimefon

Cited by 22 publications

References 45 publications

Stereoselective metabolism, distribution, and bioaccumulation brof triadimefon and triadimenol in lizards

Stereoselective metabolism, distribution, and bioaccumulation brof triadimefon and triadimenol in lizards

Methamphetamine abstinence induces changes in μ-opioid receptor, oxytocin and CRF systems: Association with an anxiogenic phenotype

The Fetal Basis of Amyloidogenesis: Exposure to Lead and Latent Overexpression of Amyloid Precursor Protein and β-Amyloid in the Aging Brain

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