Behavioral responses and Fos activation following painful stimuli in a rodent model of Parkinson's disease

Characterization of nociceptive response to chemical, mechanical, and thermal stimuli in adolescent rats with neonatal dopamine depletion

“…Similarly, in the present study, adolescent rats with neonatal dopamine depletion exhibited hyperalgesic behavioral response to the formalin injection, showing increased nociceptive behavior during the interphase and late phase 2; however, abnormal responses to mechanical and thermal stimuli were not observed. Together with the results of previous studies (Pelissier et al, 2006;Tassorelli et al, 2007;Camarasa et al, 2009), these results suggest that the dopaminergic neural system plays a crucial role in pain processing, especially tonic chemical pain. However, whether the difference in the sensitivity of the dopaminergic neural system to the stimulus depends on the intensity or type of stimulus remains unclear, because withdrawal responses in the von-Frey and tail flick tests are measured as the threshold of the nociceptive response as opposed to the formalin test, in which the nociceptive response is induced by a suprathreshold stimulus.…”

“…Furthermore, tonic pain induced by chemical stimuli is more sensitive to dopaminergic agents compared with phasic thermal and mechanical pain (Pelissier et al, 2006;Camarasa et al, 2009). A hyperalgesic response to tonic chemical stimuli with increased nociceptive behavior during the end of phase 1 and late phase 2 in the formalin test has been reported using rats with dopamine depletion during adulthood (Tassorelli et al, 2007). Similarly, in the present study, adolescent rats with neonatal dopamine depletion exhibited hyperalgesic behavioral response to the formalin injection, showing increased nociceptive behavior during the interphase and late phase 2; however, abnormal responses to mechanical and thermal stimuli were not observed.…”

“…Rats with unilateral 6-hydroxydopamine (6-OHDA)-induced lesions in the nigrostriatal dopaminergic neurons show hypersensitivity to mechanical (Saadeé t al., 1997;Takeda et al, 2005) and thermal (Saadeé t al., 1997;Chudler and Lu, 2008) stimuli. Furthermore, unilateral 6-OHDA-treated rats exhibited hyperalgesic response to pain-inducing chemical stimuli (Tassorelli et al, 2007;Chudler and Lu, 2008).…”

Effects of kynurenic acid analogue 1 (KYNA-A1) in nitroglycerin-induced hyperalgesia: Targets and anti-migraine mechanisms

“…In this study, we used the model of NTG-induced hyperalgesia at the spinal and trigeminal level (5,6) to investigate the effects of KYNA-A1. Additionally, we investigated the targets and mediators modulated by the compound in the peripheral and central areas involved in trigeminal nociception.…”

Mice with Reduced Vesicular Monoamine Storage Content Display Nonmotor Features of Parkinson's Disease: Table 1.

“…A more extensive evaluation of these data would be valuable because it has been suggested that neurodegeneration in these nuclei precedes degeneration in the substantia nigra, and this may manifest clinically as nonmotor symptoms, including olfactory deficits (Braak et al, 2003). Specifically, it will be important to determine whether age-dependent, progressive degeneration occurs in these nuclei before nigral degeneration in VMAT2-deficient animals, and if so, Intrastriatal 6-OHDA Not described Not described No (Tadaiesky et al, 2008) Yes (Branchi et al, 2008;Tadaiesky et al, 2008) Yes (Ferro et al, 2005;Tadaiesky et al, 2008) Yes (Tassorelli et al, 2007;Chudler and Lu, 2008) MPTP (systemic) Yes (Anderson et al, 2007) Yes (Monaca et al, 2004;Barraud et al, 2009) Yes (Prediger et al, 2009) Yes (Vucković et al, 2008 Yes (Reksidler et al, 2007;Prediger et al, 2009) Yes (Rosland et al, 1992) Rotenone (systemic) Yes (Drolet et al, 2009;Greene et al, 2009) Not described Not described Not described Not described Not described ␣-synuclein TG (PARK1, PARK4)…”