Behavioral profile assessment in offspring of Swiss mice treated during pregnancy and lactation with caffeine

Laureano‐Melo, Roberto; Silveira, Anderson Luiz Bezerra da; Seara, Fernando A.C.; Conceição, Rodrigo Rodrigues da; Almeida, Claudio da Silva; Marinho, Bruno Guimarães; Rocha, Fábio Fagundes da; Reis, L. C.; Cortês, Wellington da Silva

doi:10.1007/s11011-016-9847-5

Cited by 14 publications

(9 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This result is consistent with the variable findings from previous studies that described the effects of caffeine on thermal and mechanical sensations. Caffeine reduced mechanical allodynia in carrageenan-stimulated mice [ 14 ]. Caffeine also exerted short-term antinociceptive effects on the paw withdrawal latency after exposure to a noxious thermal stimulus [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Caffeine Consumption Influences Lidocaine Action via Pain-Related Voltage-Gated Sodium Channels: An In Vivo Animal Study

AlFaraj

Alabdulsalam

Alfaraj

et al. 2022

Pain Research and Management

View full text Add to dashboard Cite

Several factors might influence the duration and efficiency of local anesthesia. This study investigates the effect of habitual caffeine intake on lidocaine action and explores the potential involvement of voltage-gated sodium channels in the interaction effect. Wistar rats were divided into four groups: (i) control (Ctrl), (ii) lidocaine intraplantar injection (LIDO), (iii) habitual caffeine intake (CAF), and (iv) lidocaine intraplantar injection and habitual caffeine intake (LIDO + CAF). Behavioral assessments, consisting of a paw pressure test for mechanical pressure sensation and a paw withdrawal latency test for thermal pain sensation, were performed at 0, 30, 60, and 90 minutes following lidocaine injection and after 10, 11, and 12 weeks of CAF intake. Pressure sensation was significantly reduced in the LIDO + CAF group compared with the control group. Moreover, the LIDO + CAF group exhibited reduced sensation compared to LIDO alone group. The LIDO + CAF combination exerted a synergistic effect at 30 and 60 minutes compared with the control. This synergistic effect was noted at 60 minutes (11 weeks of CAF intake) and at 30 minutes (12 weeks of CAF intake) compared with LIDO alone. Augmented thermal pain-relieving effects were observed in the LIDO + CAF group at all weeks compared to the control group and at 10 weeks compared to LIDO alone group. The molecular analysis of dorsal root ganglia suggested that CAF upregulated the mRNA expression of the Nav1.3, Nav1.7, and Nav1.8 sodium channel subtypes. Chronic caffeine consumption potentiates the local anesthetic action of lidocaine in an experimental animal model through mechanisms that involve the upregulation of voltage-gated sodium channels in the dorsal root ganglia.

show abstract

Section: Discussionmentioning

confidence: 99%

Caffeine Consumption Influences Lidocaine Action via Pain-Related Voltage-Gated Sodium Channels: An In Vivo Animal Study

AlFaraj

Alabdulsalam

Alfaraj

et al. 2022

Pain Research and Management

View full text Add to dashboard Cite

show abstract

“…Exposure to caffeine in drinking water (75, 300, or 1,000 mg/L) in pregnant mice was sufficient to induce working memory deficits and potentiate locomotor response to acute cocaine in the resulting offspring upon reaching adulthood (Björklund et al, 2008 ; Soellner et al, 2009 ). Even perinatal exposure during lactation could modify depressive-like behavior of the offspring upon reaching adulthood, although female offspring appeared more vulnerable, and the effects were bi-directional depending on dosage (Laureano-Melo et al, 2016 ; Magenis et al, 2022 ). Nonetheless, DNA damage in the brain of adult offspring was observed regardless of sex, and thus strongly implicating that caffeine consumption during pregnancy could be detrimental to fetal brain development.…”

Section: Etiological Perspectives and Future Treatment Strategiesmentioning

confidence: 99%

The adenosine hypothesis of schizophrenia into its third decade: From neurochemical imbalance to early life etiological risks

Singer

Yee²

2023

Front. Cell. Neurosci.

View full text Add to dashboard Cite

The adenosine hypothesis of schizophrenia was conceptualized about two decades ago in an attempt to integrate two prominent theories of neurochemical imbalance that attribute the pathogenesis of schizophrenia to hyperfunction of the mesocorticolimbic dopamine neurotransmission and hypofunction of cortical glutamate neurotransmission. Given its unique position as an endogenous modulator of both dopamine and glutamate signaling in the brain, adenosine was postulated as a potential new drug target to achieve multiple antipsychotic actions. This new strategy may offer hope for improving treatment, especially in alleviating negative symptoms and cognitive deficits of schizophrenia that do not respond to current medications. To date, however, the adenosine hypothesis has yet led to any significant therapeutic breakthroughs. Here, we address two possible reasons for the impasse. First, neither the presence of adenosine functional deficiency in people with schizophrenia nor its causal relationship to symptom production has been satisfactorily examined. Second, the lack of novel adenosine-based drugs also impedes progress. This review updates the latest preclinical and clinical data pertinent to the construct validity of the adenosine hypothesis and explores novel molecular processes whereby dysregulation of adenosine signaling could be linked to the etiology of schizophrenia. It is intended to stimulate and revitalize research into the adenosine hypothesis towards the development of a new and improved generation of antipsychotic drugs that has eluded us for decades.

show abstract

“…The number of fecal pellets is an indicator of the degree of tension in animals, and the higher the number of fecal pellets, the greater the degree of tension [40,41]. As shown in Fig.…”

Section: Fecal Pellet Countmentioning

confidence: 99%

Effects of Volatile Organic Compounds (VOCs) of <i>Cinnamomum burmannii</i> in Its Natural State on Physical and Mental Health

Li¹,

Zhang²,

Wen³

et al. 2022

Pol. J. Environ. Stud.

View full text Add to dashboard Cite

Aromatic plant is an important element in the construction of landscape environment space. As an aromatic plant, Cinnamomum burmannii releases rich volatile organic compounds (VOCs), which can improve the quality of the environment, and have a health effect on the human body through smell. In order to determine the relationship between Cinnamomum burmannii VOCs and physical and mental health, the physiological and psychological indexes of volunteers were analyzed in indoor and outdoor environments with different concentrations of Cinnamomum burmannii VOCs. And the behavioral activities and physiological indexes of the animals were studied through experiments on the open field behavior of mice. Results of quantitative analysis of human physiological indicators indicated that the volunteers were in the most relaxed state at low concentration of Cinnamomum burmannii VOCs in indoor (0.10±0.04 m 3 /m 2 ), and outdoor (0.10±0.05 m 3 /m 2 ). Investigation of human psychological indicators demonstrated low concentration of Cinnamomum burmannii VOCs (0.10±0.05 m 3 /m 2 ) could relieve the stress and improve the mental state on the human body to a large extent. In addition, the open-field behavioral experiment of mice revealed the low concentration of Cinnamomum burmannii VOCs (2.04×10 -3 g/cm 3 ) had the best effect on promoting motility and exploring cognitive ability of mice. These results can provide a basis for the application of aromatic plants in the landscape environment through their health benefits.

show abstract

Behavioral profile assessment in offspring of Swiss mice treated during pregnancy and lactation with caffeine

Cited by 14 publications

References 62 publications

Caffeine Consumption Influences Lidocaine Action via Pain-Related Voltage-Gated Sodium Channels: An In Vivo Animal Study

Caffeine Consumption Influences Lidocaine Action via Pain-Related Voltage-Gated Sodium Channels: An In Vivo Animal Study

The adenosine hypothesis of schizophrenia into its third decade: From neurochemical imbalance to early life etiological risks

Effects of Volatile Organic Compounds (VOCs) of <i>Cinnamomum burmannii</i> in Its Natural State on Physical and Mental Health

Contact Info

Product

Resources

About